ArticleBMC infectious diseases2016
Utility of modified Faine's criteria in diagnosis of leptospirosis.
Article in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Diagnostic accuracy of genetic markers and nucleic acid techniques for the detection of Leptospira in clinical samples: A meta-analysis.PLoS neglected tropical diseases · 2020Pooled it
- Estimating the burden of leptospirosis in Sri Lanka; a systematic review.BMC infectious diseases · 2019Pooled it
- Article
- Leptospirosis on the edge: a case report of critical multi-organ involvement.BMC infectious diseases · 2026Article
- Clinical presentation and laboratory findings: key indicators for early diagnosis and severity prediction of leptospirosis in Sri Lanka.BMC infectious diseases · 2026Article
- Early diagnosis and treatment of leptospirosis: Optimizing clinical outcomes.The Journal of infection · 2026Review
- Leptospirosis in Central Romania: A 17-Year Single-Center Cohort Study of Hospitalized Adults.Microorganisms · 2026Article
- Severe leptospirosis in the intensive care unit: single centre prospective cohort study from Sri Lanka.BMC infectious diseases · 2026Article
- Case Report: Diagnosis of leptospirosis presenting as aseptic meningitis using metagenomics CAPture sequencing.Frontiers in medicine · 2026Article
- Leptospirosis-Improving Healthcare Outcomes for a Neglected Tropical Disease.Open forum infectious diseases · 2025Review
- Acute Calculous Cholecystitis Associated with Leptospirosis: Which is the Emergency? A Case Report and Literature Review.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2024Article
- A Fatal Case of Presumptive Diagnosis of Leptospirosis Involving the Central Nervous System.Healthcare (Basel, Switzerland) · 2024Article
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- Stillbirth and fulminant postpartum haemolysis: COVID-19 or leptospirosis or both?BMJ case reports · 2023Article
- Neuro-leptospirosis - A batty diagnostic enigma.IDCases · 2023Article
- Clinical Evaluation of the Modified Faine Criteria in Patients Admitted with Suspected Leptospirosis to the Territorial Hospital, New Caledonia, 2018 to 2019.The American journal of tropical medicine and hygiene · 2022Article
- Cardiac tamponade secondary to leptospirosis. A rare association: A case report.Journal of cardiology cases · 2021Article
- Leptospirosis as an unusual culprit of acute pancreatitis and portal vein thrombosis in a New Yorker.Clinical case reports · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeptospirosis is a globally emerging zoonotic disease and an important public health threat in developing countries. Diagnosis of leptospirosis is mainly based on clinical presentations in resource poor countries. World Health Organization (WHO) has introduced "Faine's criteria" for diagnosis of leptospirosis. This study was conducted to evaluate the usefulness of modified Faine's criteria (with amendment) 2012 to detect leptospirosis in resource poor settings.
methodsBlood samples of 168 patients who fulfilled the inclusion criteria admitted between January 2013 to January 2014 were tested by a commercial immunochromatographic assay (Leptocheck WB, India), microscopic agglutination test (MAT) and polymerase chain reaction (PCR) methods. Leptospirosis was confirmed by a single MAT titre ≥1:400 and / or by a positive PCR. Diagnosis of leptospirosis was made using the clinical, epidemiological and laboratory data according to modified Faine's criteria (with amendment) 2012.
resultsLeptospirosis was confirmed in 39 % (n = 66) by MAT and/or PCR. When modified Faine's criteria (MAT ≥ 1.400 &/ or PCR), was evaluated against LERG confirmed cases sensitivity, specificity, positive predictive value and negative predictive values were 95.45 %, 56.86 %, 58.88 %, 95.08 % respectively. The modified Faine's criteria with rapid immunochromatographic assay only had a sensitivity, specificity, positive predictive value and negative predictive value 89.39 %, 58.82 %, 58.42 %, and 89.55 % respectively.
conclusionThe modified Faine's criteria which utilized only immunochromatographic assay (leptocheck IgM) in Part C was found to be useful tool for diagnosing leptospirosis in a resource poor setting.
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