ArticleAdvances in therapy2016
Diabetic Peripheral Neuropathy as a Predictor of Asymptomatic Myocardial Ischemia in Type 2 Diabetes Mellitus: A Cross-Sectional Study.
Article in Advances in therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 34 citations in OpenAlex.
- Enhanced Left Ventricular Diastolic Function Following Diabetic Foot Treatment: A Prospective Observational Study Investigating the Impact on Cardiac Health.Health science reports · 2026Article
- Clinical characteristics of patients with diabetic peripheral neuropathy: a retrospective descriptive study.Frontiers in clinical diabetes and healthcare · 2026Article
- Self-efficacy, Knowledge and Outcomes Expectations Foot Self-care among Diabetic Patients with High-Risk Feet in Jordan.Current diabetes reviews · 2026Article
- Associations between peripheral neuropathy and cardiovascular complications in patients with type 2 diabetes mellitus: a cross-sectional study.Scientific reports · 2025Article
- Advances in the treatment of diabetic peripheral neuropathy by modulating gut microbiota with traditional Chinese medicine.World journal of diabetes · 2024Review
- Assessment of subclinical LV myocardial dysfunction in T2DM patients with diabetic peripheral neuropathy: a cardiovascular magnetic resonance study.Cardiovascular diabetology · 2024Article
- Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2022.Journal of atherosclerosis and thrombosis · 2024Article
- The role of diabetic foot treatment in improving left ventricular function: Insights from global longitudinal strain echocardiography.PloS one · 2024Article
- Subclinical left ventricular deformation and microvascular dysfunction in T2DM patients with and without peripheral neuropathy: assessed by 3.0 T cardiac magnetic resonance imaging.Cardiovascular diabetology · 2023Article
- Survival Prediction in Diabetic Foot Ulcers: A Machine Learning Approach.Journal of clinical medicine · 2023Article
- Evaluating Classification Systems of Diabetic Foot Ulcer Severity: A 12-Year Retrospective Study on Factors Impacting Survival.Healthcare (Basel, Switzerland) · 2023Article
- Comprehensive Bibliometric Analysis of Research Articles on Post-Herpetic Neuralgia and Varicella-Zoster Virus: A 20-Year Review(2003-2022).Journal of pain research · 2023Article
- Low Levels of Vitamin D and Silent Myocardial Ischemia in Type 2 Diabetes: Clinical Correlations and Prognostic Significance.Diagnostics (Basel, Switzerland) · 2022Article
- Increased levels of serum adenosine deaminase and increased risk of diabetic peripheral neuropathy in type 2 diabetes.Frontiers in endocrinology · 2022Article
- Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort.Scientific reports · 2021Article
- Peripheral Neuropathy as a Risk Factor for Developing Cardiovascular Disease in Diabetic Patients.Cureus · 2020Article
- Mortality in Patients with Diabetic Foot Ulcers: Causes, Risk Factors, and Their Association with Evolution and Severity of Ulcer.Journal of clinical medicine · 2020Article
- Article
- Assessment of telomerase activity in leukocytes of type 2 diabetes mellitus patients having or not foot ulcer: Possible correlation with other clinical parameters.Experimental and therapeutic medicine · 2018Article
- The Diabetic Foot as a Proxy for Cardiovascular Events and Mortality Review.Current atherosclerosis reports · 2017Review
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Authors and funding
9 authors at 4 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
introductionDiabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes and has been associated with cardiovascular disease, the leading cause of mortality in diabetes. As asymptomatic myocardial ischemia (MI) is frequent in diabetes, we hypothesized that DPN may be associated with MI in patients with type 2 diabetes mellitus and no history of cardiovascular events.
methodsEighty-two patients with DPN (n = 41) or without DPN (n = 41) were included. Among the DPN group, 15 had active foot ulcers. All subjects underwent Technetium-99 m sestamibi single-photon emission computed tomographic imaging for the estimation of myocardial ischemia, expressed as Summed Stress Score (SSS). The Neuropathy Disability Score (NDS) was used to quantify DPN and abnormal ratio of the longest electrocardiographic RR interval between the 28th and 32nd beats, after standing to the shortest interval between the 13th and 17th beats (RR ratio) was used as an index of cardiovascular autonomic neuropathy (CAN).
resultsAbnormal SSS was observed in 9.8% of patients without DPN and in 46.3% of patients with DPN (p < 0.001). In the multivariate analysis, NDS was the strongest predictor for SSS (β = 0.32, p = 0.003). When excluding patients with abnormal RR ratio (β = 0.32, p = 0.003) or with foot ulcers (β = 0.24, p = 0.04), this association remained significant. The RR ratio was also significantly associated with SSS in univariate (ρ = -0.30, p = 0.005) and multiple regressions (β = 0.24, p = 0.02).
conclusionsMI was strongly associated with DPN, and this association remained significant in patients with normal RR ratio. These results suggest that DPN assessment could help in identifying patients at risk of cardiovascular disease (CVD).
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