Evidence map›Paper›PMID 27553900›Full record

ArticleHearing research2016

Endothelin-1 mediated induction of extracellular matrix genes in strial marginal cells underlies strial pathology in Alport mice.

Daniel T Meehan, Duane Delimont, Brianna Dufek, Marisa Zallocchi, Grady Phillips, Michael Anne Gratton, Dominic Cosgrove

Open access · greenAbstract read
In one paragraph

Article in Hearing research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Collagen IV in Gould syndrome and Alport syndrome.Nature reviews. Nephrology · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Genotype-Based Molecular Mechanisms in Alport Syndrome.Journal of the American Society of Nephrology : JASN · 2025
    Review
  8. Review
  9. [Long-term auditory monitoring in children with Alport syndrome based on different degrees of renal injury].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Daniel T MeehanBoys Town National Research Hospital, Omaha, NE, USA.
Duane DelimontBoys Town National Research Hospital, Omaha, NE, USA.
Brianna DufekBoys Town National Research Hospital, Omaha, NE, USA.
Marisa ZallocchiBoys Town National Research Hospital, Omaha, NE, USA.
Grady PhillipsSaint Louis University, St. Louis, MO, USA.
Michael Anne GrattonSaint Louis University, St. Louis, MO, USA.
Dominic CosgroveBoys Town National Research Hospital, Omaha, NE, USA; University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: Dominic.cosgrove@boystown.org.
Boys Town National Research Hospital · USSaint Louis University · USUniversity of Nebraska Medical Center · US

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Heather Colleen Jensen-Smith · 2012 to 2026
$59.2M
UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Apar Kishor Ganti · 1985 to 2026
$55.0M
Sensory Function CoreP30DC004665 · NIDCD · WASHINGTON UNIVERSITY · PI FADDIS, BRIAN T · 2001 to 2015
$8.0M
UNMC Histology/Imaging and Creighton University Imaging Core FacilityP30GM110768 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SMITH, SHELLEY D · 2014 to 2018
$5.1M
MOLECULAR ASPECTS OF ALPORT RENAL DISEASE PROGRESSIONR01DK055000 · NIDDK · FATHER FLANAGAN'S BOYS'HOME · PI COSGROVE, DOMINIC E. · 1999 to 2013
$3.0M
RESCUE OF ALPORT SYNDROME OTOPATHOLOGYR01DC015385 · NIDCD · FATHER FLANAGAN'S BOYS' HOME · PI COSGROVE, DOMINIC E., GRATTON, MICHAEL ANNE NMI · 2016 to 2020
$2.4M
NCI NIH HHS P30 CA036727NIDCD NIH HHS P30 DC004665NIDCD NIH HHS R01 DC015385NIDDK NIH HHS R01 DK055000NIGMS NIH HHS P20 GM103427NIGMS NIH HHS P30 GM110768
6 · The paper itself

Abstract

Alport syndrome, a type IV collagen disorder, manifests as glomerular disease associated with hearing loss with thickening of the glomerular and strial capillary basement membranes (SCBMs). We have identified a role for endothelin-1 (ET-1) activation of endothelin A receptors (ET

Indexed as

AnimalsBasement MembraneBody TemperatureCapillariesCell LineCollagen Type IVDisease Models, AnimalEndothelin-1Extracellular MatrixGene Expression RegulationHypoxiaIsoxazolesLamininMiceNephritis, HereditaryOxidative StressCollagen Type IVEndothelin-1IsoxazolesLamininlaminin alpha 2laminin alpha5sitaxsentanThiophenesAlport syndromeBasement membraneStria vascularis

Identifiers

PMID27553900
PMCPMC5086449
OpenAlexW2507744561

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.