Evidence map›Paper›PMID 27553822›Full record

ArticlePsychopharmacology2016

Counteractive effects of antenatal glucocorticoid treatment on D1 receptor modulation of spatial working memory.

Kanwar Virdee, Jiska Kentrop, Bianca Jupp, Bethany Venus, Daniel Hensman, Simon McArthur, James Wilkinson, Trevor W Robbins, Glenda Gillies, Jeffrey W Dalley

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Kanwar VirdeeDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
Jiska KentropDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
Bianca JuppDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
Bethany VenusDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
Daniel HensmanDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
Simon McArthurDepartment of Biomedical Sciences, University of Westminster, New Cavendish Street, London, W1W 6UW, UK.
James WilkinsonDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
Trevor W RobbinsDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
Glenda GilliesDivision of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.
Jeffrey W DalleyDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK. jwd20@cam.ac.uk.
University of Cambridge · GBHammersmith Hospital · GBUniversity of Westminster · GB

Funding

Medical Research Council G0001354Medical Research Council G0701500Medical Research Council G1000018Medical Research Council G1000183Medical Research Council MR/J012084/1Wellcome Trust 086871/Z/08/ZWellcome Trust 093875
6 · The paper itself

Abstract

rationaleAntenatal exposure to the glucocorticoid dexamethasone dramatically increases the number of mesencephalic dopaminergic neurons in rat offspring. However, the consequences of this expansion in midbrain dopamine (DA) neurons for behavioural processes in adulthood are poorly understood, including working memory that depends on DA transmission in the prefrontal cortex (PFC).

objectivesWe therefore investigated the influence of antenatal glucocorticoid treatment (AGT) on the modulation of spatial working memory by a D

methodsPregnant rats received AGT on gestational days 16-19 by adding dexamethasone to their drinking water. Male offspring reared to adulthood were trained on a delayed alternation spatial working memory task and administered the partial D

resultsSKF38393 impaired spatial working memory performance in control rats but had no effect in AGT rats. D

conclusionsThese findings demonstrate that D

Indexed as

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineAnimalsBasal ForebrainBehavior, AnimalBiogenic MonoaminesBrainCorpus StriatumDexamethasoneDopamineDopamine AgonistsDopaminergic NeuronsFemaleGlucocorticoidsGyrus CinguliLocomotionMale2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineBiogenic MonoaminesDexamethasoneDopamineDopamine AgonistsGlucocorticoidsReceptors, Dopamine D1DopamineDopamine receptorsMemoryPrefrontal cortexSchizophrenia

Identifiers

PMID27553822
PMCPMC5063912
OpenAlexW2518373312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.