Trial reportReproductive biology and endocrinology : RB&E2016
Different effectiveness of closed embryo culture system with time-lapse imaging (EmbryoScope(TM)) in comparison to standard manual embryology in good and poor prognosis patients: a prospectively randomized pilot study.
Trial report in Reproductive biology and endocrinology : RB&E, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison Of The Embryoscope Time-Lapse System With Standard Embryo Culture at Center for Human Reproduction(CHR):an Open Label Randomized Clinical Trial
The Application of Time-lapse System in IVF/ICSI: Can it be Beneficial to Final Pregnancy Outcome?
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Time-lapse systems for embryo incubation and assessment in assisted reproduction.The Cochrane database of systematic reviews · 2019Pooled it
- Time-lapse systems for embryo incubation and assessment in assisted reproduction.The Cochrane database of systematic reviews · 2018Pooled it
- Pooled it
- Prioritizing embryologist health: occupational health hazards and preventive strategies.Frontiers in public health · 2026Review
- MicroRNAomic Analysis of Spent Media from Slow- and Fast-Growing Bovine Embryos Reveal Distinct Differences.Animals : an open access journal from MDPI · 2024Article
- Artificial Intelligence-Based Detection of Human Embryo Components for Assisted Reproduction by In Vitro Fertilization.Sensors (Basel, Switzerland) · 2022Article
- Deep Learning-Enabled Technologies for Bioimage Analysis.Micromachines · 2022Review
- Article
- Evaluating the value of day 0 of an ICSI cycle on indicating laboratory outcome.Scientific reports · 2020Observational
- Consistency and objectivity of automated embryo assessments using deep neural networks.Fertility and sterility · 2020Article
- Development and evaluation of inexpensive automated deep learning-based imaging systems for embryology.Lab on a chip · 2019Article
- Biodynamic optical assay for embryo viability.Journal of biomedical optics · 2019Article
- Embryo wastage rates remain high in assisted reproductive technology (ART): a look at the trends from 2004-2013 in the USA.Journal of assisted reproduction and genetics · 2017Article
- Improving IVF: is there a limit to our ability to manipulate human biology?Journal of assisted reproduction and genetics · 2017Article
- Time-Lapse Culture Improves Development and Pregnancy Outcomes of Sibling Normally Fertilized Oocytes: A Prospective Multicenter Study.Reproductive medicine and biologyArticle
- A Study to Find Optimal Intra-cytoplasmic Sperm Injection Timing of Oocytes Matured from Germinal Vesicle inJournal of human reproductive sciencesArticle
- The clinical use of time-lapse in human-assisted reproduction.Therapeutic advances in reproductive healthReview
- Impact of Time-Lapse Incubator Systems on Fertilization, Blastocyst Development, and Clinical Pregnancy Outcomes.Journal of reproduction & infertilityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreviously manual human embryology in many in vitro fertilization (IVF) centers is rapidly being replaced by closed embryo incubation systems with time-lapse imaging. Whether such systems perform comparably to manual embryology in different IVF patient populations has, however, never before been investigated. We, therefore, prospectively compared embryo quality following closed system culture with time-lapse photography (EmbryoScope™) and standard embryology. We performed a two-part prospectively randomized study in IVF (clinical trial # NCT92256309). Part A involved 31 infertile poor prognosis patients prospectively randomized to EmbryoScope™ and standard embryology. Part B involved embryos from 17 egg donor-recipient cycles resulting in large egg/embryo numbers, thus permitting prospectively alternative embryo assignments to EmbryoScope™ and standard embryology. We then compared pregnancy rates and embryo quality on day-3 after fertilization and embryologist time utilized per processed embryo.
resultsPart A revealed in poor prognosis patients no differences in day-3 embryo scores, implantation and clinical pregnancy rates between EmbryoScope™ and standard embryology. The EmbryoScope™, however, more than doubled embryology staff time (P < 0.0001). In Part B, embryos grown in the EmbyoScope™ demonstrated significantly poorer day-3 quality (depending on embryo parameter between P = 0.005 and P = 0.01). Suspicion that conical culture dishes of the EmbryoScope™ (EmbryoSlide™) may be the cause was disproven when standard culture dishes demonstrated no outcome difference in standard incubation.
conclusionsThough due to small patient numbers preliminary, this study raises concerns about the mostly uncontrolled introduction of closed incubation systems with time lapse imaging into routine clinical embryology. Appropriately designed and powered prospectively randomized studies appear urgently needed in well-defined patient populations before the uncontrolled utilization of these instruments further expands.
trial registrationNCT02246309 Registered September 18, 2014.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.