ArticleBMC veterinary research2016
Lymphocytic, cytokine and transcriptomic profiles in peripheral blood of dogs with atopic dermatitis.
Article in BMC veterinary research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 66 citations in OpenAlex.
- Treatment-Associated Differences in Serum Cytokine Profiles in Canine Atopic Dermatitis: A Cross-Sectional Study.Animals : an open access journal from MDPI · 2026Article
- Serum Cytokine Profiles and Their Association with Clinical Severity in Dogs with Atopic Dermatitis.Animals : an open access journal from MDPI · 2026Article
- Effects of Canine-DerivedAnimals : an open access journal from MDPI · 2026Article
- Periostin: a potential biomarker for diagnosis and treatment monitoring in canine atopic dermatitis.The veterinary quarterly · 2025Article
- The effects of leukocyteBMC veterinary research · 2025Article
- Effects of moderate-protein and high-protein diets, including mealworm meal or poultry by-product meal, on immunological variables in healthy adult dogs.BMC veterinary research · 2025Article
- Oral treatment withFrontiers in veterinary science · 2025Article
- Use of D-SquameVeterinary sciences · 2024Article
- Treatment with oclacitinib, a Janus kinase inhibitor, down-regulates and up-regulates CD25 and Foxp3 expression, respectively, in peripheral blood T cells of dogs with atopic dermatitis.BMC veterinary research · 2024Article
- A review of CD4Veterinary immunology and immunopathology · 2024Review
- Investigation of the relationship between atopic dermatitis of dogs and intestinal epithelial damage.Veterinary medicine and science · 2024Article
- Effect of Bacillus subtilis and Bacillus coagulans spores on induced allergic contact dermatitis in dogs.Veterinary medicine and science · 2024Article
- Immune-Modulating Effects of Low-Carbohydrate Ketogenic Foods in Healthy Canines.Current developments in nutrition · 2024Article
- Canine peripheral non-conventional TCRαβFrontiers in immunology · 2024Article
- Non-controlled, open-label trial to assess clinical and immunological parameters in atopic dogs feeding monoprotein grain free dietThe veterinary quarterly · 2023Article
- Primary Prevention of Canine Atopic Dermatitis: Breaking the Cycle-A Narrative Review.Veterinary sciences · 2023Review
- Effect of Allergen-Specific Immunotherapy on Transcriptomic Changes in Canine Atopic Dermatitis.International journal of molecular sciences · 2023Article
- Is Vitamin D3 a Worthy Supplement Protecting against Secondary Infections in Dogs with Atopic Dermatitis?Pathogens (Basel, Switzerland) · 2023Review
- Snail Mucus Filtrate Reduces Inflammation in Canine Progenitor Epidermal Keratinocytes (CPEK).Animals : an open access journal from MDPI · 2022Article
- Cytokine and Lymphocyte Profiles in Dogs with Atopic Dermatitis after Allergen-Specific Immunotherapy.Vaccines · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCanine atopic dermatitis (cAD) is a common chronic and pruritic skin disease in dogs. The development of cAD involves complex interactions between environmental antigens, genetic predisposition and a number of disparate cell types. The aim of the present study was to perform comprehensive analyses of peripheral blood of AD dogs in relation to healthy subjects in order to determine the changes which would be characteristic for cAD.
resultsThe number of cells in specific subpopulations of lymphocytes was analyzed by flow cytometry, concentration of chosen pro- and anti-inflammatory cytokines (IL-4, IL-10, IL-13, TNF-α, TGF-β1) was determined by ELISA; and microarray analysis was performed on RNA samples isolated from peripheral blood nuclear cells of AD and healthy dogs. The number of Th cells (CD3(+)CD4(+)) in AD and healthy dogs was similar, whereas the percentage of Tc (CD3(+)CD8(+)) and Treg (CD4(+)CD25(+) Foxp3(+)) cells increased significantly in AD dogs. Increased concentrations of IL-13 and TNF-α, and decreased levels of IL-10 and TGF-β1 was observed in AD dogs. The level of IL-4 was similar in both groups of animals. Results of the microarray experiment revealed differentially expressed genes involved in transcriptional regulation (e.g., transcription factors: SMAD2, RORA) or signal transduction pathways (e.g., VEGF, SHB21, PROC) taking part in T lymphocytes lineages differentiation and cytokines synthesis.
conclusionsResults obtained indicate that CD8(+) T cells, beside CD4(+) T lymphocytes, contribute to the development of the allergic response. Increased IL-13 concentration in AD dogs suggests that this cytokine may play more important role than IL-4 in mediating changes induced by allergic inflammation. Furthermore, observed increase in Treg cells in parallel with high concentrations of TNF-α and low levels of IL-10 and TGF-β1 in the peripheral blood of AD dogs point at the functional insufficiency of Treg cells in patients with AD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.