Evidence map›Paper›PMID 27553495›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2016

Molecular epidemiology of Staphylococcus aureus from Lambaréné, Gabon.

K V Okuda, N Toepfner, A S Alabi, B Arnold, S Bélard, U Falke, L Menschner, S Monecke, A Ruppelt-Lorz, R Berner

Abstract read
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In one paragraph

Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Global prevalence of macrolide-resistantFrontiers in microbiology · 2025
    Pooled it
  2. Prevalence and risk factors of antimicrobial resistance inOne health (Amsterdam, Netherlands) · 2026
    Article
  3. Clonal Complexes Distribution ofAntibiotics (Basel, Switzerland) · 2023
    Article
  4. Microorganisms · 2023
    Article
  5. Review
  6. Sequence Analysis of NovelInternational journal of molecular sciences · 2022
    Article
  7. Microorganisms · 2022
    Review
  8. Description of Staphylococcal Strains from Straw-Coloured Fruit Bat (Frontiers in cellular and infection microbiology · 2022
    Review
  9. Review
  10. Article
  11. Lateral Flow Immunoassay for the Detection of Panton-Valentine Leukocidin inFrontiers in cellular and infection microbiology · 2021
    Article
  12. Frontiers in microbiology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

K V OkudaDepartment for Pediatrics, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
N ToepfnerDepartment for Pediatrics, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
A S AlabiCentre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.
B ArnoldDepartment for Pediatrics, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
S BélardInstitut für Tropenmedizin, Eberhard Karls Universität Tübingen and Deutsches Zentrum für Infektionsforschung, Tübingen, Germany.
U FalkeDepartment for Pediatrics, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
L MenschnerDepartment for Pediatrics, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
S MoneckeInstitute for Medical Microbiology and Hygiene, "Carl Gustav Carus", Technische Universität Dresden, Dresden, Germany. monecke@rocketmail.com.
A Ruppelt-LorzInstitute for Medical Microbiology and Hygiene, "Carl Gustav Carus", Technische Universität Dresden, Dresden, Germany.
R BernerDepartment for Pediatrics, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While there is an abundance of data on the epidemiology and molecular typing of Staphylococcus aureus, especially those carrying Panton-Valentine leucocidin (PVL) genes or mecA from Western Europe, Northern America and Australia, comparably few studies target African strains. In this study, we characterised genes associated with virulence and resistance, as well the phylogenetic background of S. aureus from healthy carriers and outpatients in Gabon. In total, 103 isolates from 96 study participants were characterised. Seventy-nine isolates originated from throat swabs and 24 isolates from skin lesions. Three isolates carried mecA, although only one, belonging to CC8-MRSA-IV [PVL+] 'USA300', was found to be phenotypically oxacillin-resistant; two CC88-MRSA-IV isolates appeared to be oxacillin-susceptible. PVL genes were common, with a total of 44 isolates (43 %) found to be PVL-positive. CC15-MSSA [PVL+] (n = 29) and CC152-MSSA [PVL+] (n = 9) were the predominant clones among the PVL-positive isolates. Among PVL-negative isolates, CC5-MSSA (n = 12), CC101-MSSA (n = 10) and CC15 (n = 9) were the most frequent. A hitherto undescribed multilocus sequence type of S. schweitzeri was detected twice in unrelated patients. The data emphasise a need for further studies on the role of PVL in African populations and the clinical significance of S. schweitzeri.

Indexed as

AdolescentAdultBacterial ProteinsBacterial ToxinsCarrier StateChildChild, PreschoolCross-Sectional StudiesExotoxinsFemaleGabonGenotypeHumansLeukocidinsMaleMolecular EpidemiologyBacterial ProteinsBacterial ToxinsExotoxinsLeukocidinsmecA protein, Staphylococcus aureusPanton-Valentine leukocidinPenicillin-Binding Proteins

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.