ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017
Fractures in spina bifida from childhood to young adulthood.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Healthcare utilization in patients with spina bifida and bone fractures.Journal of rehabilitation medicine · 2026Observational
- Article
- Management of Stone Disease in the Spina Bifida Patient.Current urology reports · 2025Review
- Pediatric Spina Bifida and Spinal Cord Injury.Journal of personalized medicine · 2022Article
- Musculoskeletal Morbidity Among Adults Living With Spina Bifida and Cerebral Palsy.Topics in spinal cord injury rehabilitation · 2022Article
- Health Concerns of Adolescents and Adults With Spina Bifida.Frontiers in neurology · 2021Article
- Quantitative Computed Tomography Assessment of Bone Deficits in Ambulatory Children and Adolescents with Spina Bifida: Importance of Puberty.JBMR plus · 2020Article
- Age-specific occurrence of pathological fractures in patients with spina bifida.European journal of pediatrics · 2020Article
- Femoral shaft fractures in children with non-ambulatory neuromuscular disorders can be effectively treated using flexible intramedullary nails.Journal of children's orthopaedics · 2020Review
- Abnormal level of CUL4B-mediated histone H2A ubiquitination causes disruptive HOX gene expression.Epigenetics & chromatin · 2019Article
- Genetics of Bone and Muscle Interactions in Humans.Current osteoporosis reports · 2019Review
- Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice.Scientific reports · 2018Article
- Fat-Bone Interactions in Adults With Spina Bifida.Journal of the Endocrine Society · 2017Article
- Muscle-Bone Interactions in Pediatric Bone Diseases.Current osteoporosis reports · 2017Review
- Muscle abnormalities in osteogenesis imperfecta.Journal of musculoskeletal & neuronal interactions · 2017Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study assessed the prevalence and types of fractures in spina bifida and examined risk factors for fracture. Fracture prevalence was highest in childhood and reduced in adolescence and young adulthood. The importance of maintaining mobility is highlighted by the increased risk of fracture in those who are non-ambulatory.
introductionThe aims of this study are to study the prevalence and types of fractures according to age group in spina bifida and examine risk factors associated with fracture.
methodsThis is a retrospective cohort study of 146 individuals with spina bifida aged 2 years or older who attended the paediatric or adult spina bifida multidisciplinary clinic at a single tertiary hospital.
resultsMedian age at which first fracture occurred was 7 years (interquartile range 4-13 years). Fracture rates in children (ages 2-10), adolescents (ages 11-18) and adults (age > 18) were 10.9/1000 (95 % confidence interval 5.9-18.3), 5.4/1000 (95 % CI 1.5-13.8) and 2.9/1000 (95 % CI 0.6-8.1) patient years respectively. Childhood fractures predominantly involved the distal femur and femoral shaft; these fractures were rarely seen in adulthood. Non-ambulatory status was associated with a 9.8 times higher risk of fracture compared with ambulatory patients (odds ratio 9.8, p = 0.016, 95 % CI 1.5-63.0). Relative risk of re-fracture was 3.1 (95 % CI 1.4-6.8). Urological intervention with intestinal segments was associated with renal calculi (p = 0.037) but neither was associated with fracture.
conclusionsThe risk of fracture is lower in adults compared with children with spina bifida. The predominant childhood fracture affects the distal femur, and immobility is the most significant risk factor for fracture. Clinical factors contributing to fracture risk need to be elucidated to enable selection of patients who require investigation and treatment of osteoporosis.
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