Evidence map›Paper›PMID 27553209›Full record

ArticleMedical decision making : an international journal of the Society for Medical Decision Making2016

The Impact of Diabetes-Related Complications on Preference-Based Measures of Health-Related Quality of Life in Adults with Type I Diabetes.

Tessa Peasgood, Alan Brennan, Peter Mansell, Jackie Elliott, Hasan Basarir, Jen Kruger

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical decision making : an international journal of the Society for Medical Decision Making, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
15.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
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  10. Quality of Life in Patients with Posterior Segment Eye Diseases.Journal of ophthalmic & vision research · 2026
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  14. Cost-Effectiveness of FreeStyle Libre for Glucose Self-Management Among People with Diabetes Mellitus: A Canadian Private Payer Perspective.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Tessa PeasgoodSchool of Health and Related Research, University of Sheffield, Sheffield, United Kingdom (TP, AB, HB, JK)
Alan BrennanSchool of Health and Related Research, University of Sheffield, Sheffield, United Kingdom (TP, AB, HB, JK)
Peter MansellDepartment of Diabetes and Endocrinology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom (PM)
Jackie ElliottAcademic Unit of Diabetes, Endocrinology and Metabolism, Department of Human Metabolism, School of Medicine and Biomedical Sciences, Sheffield, United Kingdom (JE)
Hasan BasarirSchool of Health and Related Research, University of Sheffield, Sheffield, United Kingdom (TP, AB, HB, JK)
Jen KrugerSchool of Health and Related Research, University of Sheffield, Sheffield, United Kingdom (TP, AB, HB, JK)
University of Sheffield · GBNottingham University Hospitals NHS Trust · GBOxford Centre for Diabetes, Endocrinology and Metabolism · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study estimates health-related quality of life (HRQoL) or utility decrements associated with type 1 diabetes mellitus (T1DM) using data from a UK research program on the Dose Adjustment For Normal Eating (DAFNE) education program.

methodsA wide range of data was collected from 2341 individuals who undertook a DAFNE course in 2009-2012, at baseline and for 2 subsequent years. We use fixed- and random-effects linear models to generate utility estimates for T1DM using different instruments: EQ-5D, SF-6D, and EQ-VAS. We show models with and without controls for HbA1c and depression, which may be endogenous (if, for example, there is reverse causality in operation).

resultsWe find strong evidence of an unobserved individual effect, suggesting the superiority of the fixed-effects model. Depression shows the greatest decrement across all the models in the preferred fixed-effects model. The fixed-effects EQ-5D model also finds a significant decrement from retinopathy, body mass index, and HbA1c (%). Estimating a decrement using the fixed-effects model is not possible for some conditions where there are few new cases. In the random-effects model, diabetic foot disease shows substantial utility decrements, yet these are not significant in the fixed-effects models.

conclusionUtility decrements have been calculated for a wide variety of health states in T1DM that can be used in economic analyses. However, despite the large data set, the low incidence of several complications leads to uncertainty in calculating the utility weights. Depression and diabetic foot disease result in a substantial loss in HRQoL for patients with T1DM. HbA1c (%) appears to have an independent negative impact on HRQoL, although concerns remain regarding the potential endogeneity of this variable.

Indexed as

Quality of LifeAdultBody Mass IndexDepressionDiabetes ComplicationsDiabetes Mellitus, Type 1FemaleGlycated HemoglobinHumansMaleMiddle AgedModels, StatisticalSeverity of Illness IndexSurveys and QuestionnairesUnited KingdomGlycated HemoglobindepressionEQ-5DEQ-VASHbA1chealth-related quality of lifeSF-6DT1DMtype 1 diabetesutility

Identifiers

PMID27553209
PMCPMC5046160
OpenAlexW2338517537

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.