ReviewJournal of molecular endocrinology2017
Getting to the heart of intracellular glucocorticoid regeneration: 11β-HSD1 in the myocardium.
Review in Journal of molecular endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Review
- Journal Club Article: The STEROHCA trial - Optimizing post resuscitation haemodynamics by prehospital high dose corticosteroids.Resuscitation plus · 2025Article
- Cardiac response to chronic restraint stress involves mineralocorticoid receptors in male Sprague-Dawley rats.Physiological reports · 2025Article
- Mineralocorticoid axis activity and cardiac remodeling in patients with ACTH-dependent Cushing's syndrome.Endocrine connections · 2025Article
- Cilia-enriched oxysterol 7β,27-DHC is required for polycystin ion channel activation.Nature communications · 2024Article
- Cardiac disease in Cushing's syndrome. Emphasis on the role of cardiovascular magnetic resonance imaging.Endocrine · 2024Review
- Hypoxia Attenuates Pressure Overload-Induced Heart Failure.Journal of the American Heart Association · 2024Article
- First Evidence of Mineralocorticoid Receptor Gene and Protein Expression in Rat and Human Thyroid Tissues and Cell Cultures.International journal of molecular sciences · 2024Article
- New insights into the roles of glucocorticoid signaling dysregulation in pathological cardiac hypertrophy.Heart failure reviews · 2022Review
- Association between cortisol and left ventricular diastolic dysfunction in patients with diabetes mellitus.Journal of diabetes investigation · 2022Article
- Identification of glucocorticoid receptors as potential modulators of parasympathetic and sympathetic neurons within rat intracardiac ganglia.Frontiers in neuroanatomy · 2022Article
- Food Enrichment withNutrients · 2021Article
- Cortisol on Circadian Rhythm and Its Effect on Cardiovascular System.International journal of environmental research and public health · 2021Review
- Deficit of glucocorticoid-induced leucine zipper amplifies angiotensin-induced cardiomyocyte hypertrophy and diastolic dysfunction.Journal of cellular and molecular medicine · 2021Article
- Identification of Mineralocorticoid Receptors, Aldosterone, and Its Processing Enzyme CYP11B2 on Parasympathetic and Sympathetic Neurons in Rat Intracardiac Ganglia.Frontiers in neuroanatomy · 2021Article
- Antenatal dexamethasone treatment transiently alters diastolic function in the mouse fetal heart.The Journal of endocrinology · 2019Article
- Multiple short-chain dehydrogenases/reductases are regulated in pathological cardiac hypertrophy.FEBS open bio · 2018Article
- Post-Traumatic Stress Disorder and Cardiovascular Diseases: A Cohort Study of Men and Women Involved in Cleaning the Debris of the World Trade Center Complex.Circulation. Cardiovascular quality and outcomes · 2018Observational
- Anti-inflammatory therapies in myocardial infarction: failures, hopes and challenges.British journal of pharmacology · 2018Review
- The glucocorticoid receptor in monocyte-derived macrophages is critical for cardiac infarct repair and remodeling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Corticosteroids influence the development and function of the heart and its response to injury and pressure overload via actions on glucocorticoid (GR) and mineralocorticoid (MR) receptors. Systemic corticosteroid concentration depends largely on the activity of the hypothalamic-pituitary-adrenal (HPA) axis, but glucocorticoid can also be regenerated from intrinsically inert metabolites by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), selectively increasing glucocorticoid levels within cells and tissues. Extensive studies have revealed the roles for glucocorticoid regeneration by 11β-HSD1 in liver, adipose, brain and other tissues, but until recently, there has been little focus on the heart. This article reviews the evidence for glucocorticoid metabolism by 11β-HSD1 in the heart and for a role of 11β-HSD1 activity in determining the myocardial growth and physiological function. We also consider the potential of 11β-HSD1 as a therapeutic target to enhance repair after myocardial infarction and to prevent the development of cardiac remodelling and heart failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.