ArticleJournal of physiology, Paris2016
Modulatory compartments in cortex and local regulation of cholinergic tone.
Article in Journal of physiology, Paris, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Nicotine causes highly localized and tuned changes in thalamocortical gain that cascade strongly and selectively through the cortical circuit.bioRxiv : the preprint server for biology · 2026Article
- Quantitative anatomy and biophysical modeling of ascending neuromodulatory systems in the developing rat neocortex.PLoS computational biology · 2026Article
- Release and Reuptake Sites for Norepinephrine Are Differently Distributed Across Layers of the Primary Visual Cortex in Macaque Monkeys.The Journal of comparative neurology · 2025Article
- Research advances in children's sleep and vitamin D levels.Annals of pediatric endocrinology & metabolism · 2025Article
- Neuroanatomical Substrates of Circuit-Specific Cholinergic Modulation across the Primate Anterior Cingulate Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Dose-Dependent Dissociation of Pro-cognitive Effects of Donepezil on Attention and Cognitive Flexibility in Rhesus Monkeys.Biological psychiatry global open science · 2023Article
- Cytochrome oxidase "blobs": a call for more anatomy.Brain structure & function · 2021Review
- Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1.Scientific reports · 2021Article
- Cholinergic manipulations affect sensory responses but not attentional enhancement in macaque MT.BMC biology · 2021Article
- Muscarinic Acetylcholine Receptor Localization on Distinct Excitatory and Inhibitory Neurons Within the ACC and LPFC of the Rhesus Monkey.Frontiers in neural circuits · 2021Article
- Diverse Spatiotemporal Scales of Cholinergic Signaling in the Neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Review
- Forebrain Cholinergic Signaling: Wired and Phasic, Not Tonic, and Causing Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Review
- Mesoscopic Mapping of Stimulus-Selective Response Plasticity in the Visual Pathways Modulated by the Cholinergic System.Frontiers in neural circuits · 2020Article
- Cell class-specific modulation of attentional signals by acetylcholine in macaque frontal eye field.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Cholinergic modulation of striatal microcircuits.The European journal of neuroscience · 2019Review
- Structure and function of dual-source cholinergic modulation in early vision.The Journal of comparative neurology · 2019Review
- Two distinct profiles of fMRI and neurophysiological activity elicited by acetylcholine in visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Most calbindin-immunoreactive neurons, but few calretinin-immunoreactive neurons, express the m1 acetylcholine receptor in the middle temporal visual area of the macaque monkey.Brain and behavior · 2018Article
- Topographic Organization of Cholinergic Innervation From the Basal Forebrain to the Visual Cortex in the Rat.Frontiers in neural circuits · 2018Article
- Is There a Canonical Cortical Circuit for the Cholinergic System? Anatomical Differences Across Common Model Systems.Frontiers in neural circuits · 2018Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Neuromodulatory signaling is generally considered broad in its impact across cortex. However, variations in the characteristics of cortical circuits may introduce regionally-specific responses to diffuse modulatory signals. Features such as patterns of axonal innervation, tissue tortuosity and molecular diffusion, effectiveness of degradation pathways, subcellular receptor localization, and patterns of receptor expression can lead to local modification of modulatory inputs. We propose that modulatory compartments exist in cortex and can be defined by variation in structural features of local circuits. Further, we argue that these compartments are responsible for local regulation of neuromodulatory tone. For the cholinergic system, these modulatory compartments are regions of cortical tissue within which signaling conditions for acetylcholine are relatively uniform, but between which signaling can vary profoundly. In the visual system, evidence for the existence of compartments indicates that cholinergic modulation likely differs across the visual pathway. We argue that the existence of these compartments calls for thinking about cholinergic modulation in terms of finer-grained control of local cortical circuits than is implied by the traditional view of this system as a diffuse modulator. Further, an understanding of modulatory compartments provides an opportunity to better understand and perhaps correct signal modifications that lead to pathological states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.