Evidence map›Paper›PMID 27552971›Full record

ReviewNature reviews. Molecular cell biology2016

Slowing ageing by design: the rise of NAD

Michael S Bonkowski, David A Sinclair

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Molecular cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04841499 (Effects of a Seven-day BASIS™ Supplementation on Menopausal Syndromes and Measurements of the Urinary Vitamin B3 and Estradiol Levels in Pre-, Peri- and Post-menopause), which is not on this map. Cited by 459 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
459citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04841499 nacompletednot on this mapstarted 2021, after this paper: background citation

Effects of a Seven-day BASIS™ Supplementation on Menopausal Syndromes and Measurements of the Urinary Vitamin B3 and Estradiol Levels in Pre-, Peri- and Post-menopause

TypeinterventionalSponsorUniversity of South AlabamaRan2021 to 2021Enrolled40ConditionsMenopauseArmsBASIS™ (Crystalline Nicotinamide Riboside 250mg and Pterostilbene 50mg)
3 · Its place in the literature

Who cites it

459 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Article
  7. The Hallmarks of Aging: From Molecular Mechanisms to Clinical Translation.International journal of molecular sciences · 2026
    Review
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399 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Michael S BonkowskiDepartment of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
David A SinclairDepartment of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

Funding

SIRT1 as a regulator of health and lifespan of mammalsR37AG028730 · NIA · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2012 to 2021
$4.1M
Elucidating mechanisms of SIRT1 activationR01DK100263 · NIDDK · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2016 to 2020
$2.5M
NIA NIH HHS R37 AG028730NIDDK NIH HHS R01 DK100263
6 · The paper itself

Abstract

The sirtuins (SIRT1-7) are a family of nicotinamide adenine dinucleotide (NAD

Indexed as

AgingAllosteric RegulationAnimalsClinical Trials as TopicEnzyme ActivatorsHumansNADResveratrolSirtuinsStilbenesEnzyme ActivatorsNADResveratrolSirtuinsStilbenes

Identifiers

PMID27552971
PMCPMC5107309

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.