ArticleEuropean archives of psychiatry and clinical neuroscience2017
The emerging role of the FKBP5 gene polymorphisms in vulnerability-stress model of schizophrenia: further evidence from a Serbian population.
Article in European archives of psychiatry and clinical neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 28 citations in OpenAlex.
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- Genetic Contributions to Attachment Stability Over Time: the Roles of CRHR1 Polymorphisms.Journal of youth and adolescence · 2024Article
- Stress-induced symptom exacerbation: Stress increases voiding frequency, somatic sensitivity, and urinary bladder NGF and BDNF expression in mice with subthreshold cyclophosphamide (CYP).Frontiers in urology · 2023Article
- Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discovery.Frontiers in psychiatry · 2023Review
- The association of FKBP5 polymorphisms with the severity of depressive disorder in patients with methamphetamine use disorders.Frontiers in psychiatry · 2023Article
- The Moderating Role of theJournal of clinical medicine · 2022Article
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- Intrabladder PAC1 Receptor Antagonist, PACAP(6-38), Reduces Urinary Bladder Frequency and Pelvic Sensitivity in Mice Exposed to Repeated Variate Stress (RVS).Journal of molecular neuroscience : MN · 2021Article
- The Impact of theBrain sciences · 2021Article
- Adverse Childhood Experiences and Methylation of theJournal of clinical medicine · 2020Article
- Gene-Environment Interactions in Psychiatry: Recent Evidence and Clinical Implications.Current psychiatry reports · 2019Review
- Hypothalamic-pituitary-adrenal axis variants and childhood trauma influence anxiety sensitivity in South African adolescents.Metabolic brain disease · 2018Article
- Hsp90 and FKBP51: complex regulators of psychiatric diseases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Understanding gene × early adversity interactions: possibilities for insight in the biology of psychiatric disorders.European archives of psychiatry and clinical neuroscience · 2017Article
- PACAP/Receptor System in Urinary Bladder Dysfunction and Pelvic Pain Following Urinary Bladder Inflammation or Stress.Frontiers in systems neuroscience · 2017Review
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Increased reactivity to stress is observed in patients with schizophrenia spectrum disorders and their healthy siblings in comparison with the general population. Additionally, higher levels of neuroticism, as a proposed psychological measure of stress sensitivity, increase the risk of schizophrenia. HPA axis dysregulation is one of the possible mechanisms related to the vulnerability-stress model of schizophrenia, and recent studies revealed a possible role of the functional genetic variants of FK506-binding protein 51 (FKBP5) gene which modulate activity of HPA axis. The purpose of the present study was to investigate impact of FKBP5 on schizophrenia in Serbian patients and to explore relationship between genetic variants and neuroticism by using the case-sibling-control design. In 158 subjects, we measured psychotic experiences, childhood trauma and neuroticism. Nine single-nucleotide polymorphisms (rs9295158, rs3800373, rs9740080, rs737054, rs6926133, rs9380529, rs9394314, rs2766533 and rs12200498) were genotyped. The genetic influence was modeled using logistic regression, and the relationship between genetic variants and neuroticism was assessed by linear mixed model. Our results revealed genetic main effect of FKBP5 risk alleles (A allele of rs9296158 and T allele of rs3800373) and AGTC "risk" haplotype combination (rs9296158, rs3800373, rs9470080 and rs737054, respectively) on schizophrenia, particularly when childhood trauma was set as a confounding factor. We confirmed strong relationship between neuroticism and psychotic experiences in patients and siblings and further showed relationship between higher levels of neuroticism and FKBP5 risk variants suggesting potential link between biological and psychosocial risk factors. Our data support previous findings that trauma exposure shapes FKBP5 impact on schizophrenia.
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