ArticleBMC genomics2016
Living apart together: crosstalk between the core and supernumerary genomes in a fungal plant pathogen.
Article in BMC genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 72 citations in OpenAlex.
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- Discovery of Fusadapamides, Accessory Chromosome-Associated Metabolites Incorporating l-2,3-Diaminopropionic Acid inJournal of natural products · 2025Article
- FunFEA: an R package for fungal functional enrichment analysis.BMC bioinformatics · 2025Article
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- Debunking the Myth ofJournal of agricultural and food chemistry · 2024Article
- Genomic and Metabolomic Analysis of the Endophytic FungusJournal of fungi (Basel, Switzerland) · 2023Article
- The pangenome of the wheat pathogen Pyrenophora tritici-repentis reveals novel transposons associated with necrotrophic effectors ToxA and ToxB.BMC biology · 2022Article
- Insights on KP4 Killer Toxin-like Proteins ofJournal of fungi (Basel, Switzerland) · 2022Article
- De novo genome assembly and functional annotation for Fusarium langsethiae.BMC genomics · 2022Article
- Naturally OccurringToxins · 2021Article
- Apicidin biosynthesis is linked to accessory chromosomes in Fusarium poae isolates.BMC genomics · 2021Article
- Genomic rearrangements generate hypervariable mini-chromosomes in host-specific isolates of the blast fungus.PLoS genetics · 2021Article
- Presence of the Weakly PathogenicFrontiers in plant science · 2021Article
- Accessory Chromosome-Acquired Secondary Metabolism in Plant Pathogenic Fungi: The Evolution of Biotrophs Into Host-Specific Pathogens.Frontiers in microbiology · 2021Review
- Evolution of B Chromosomes: From Dispensable Parasitic Chromosomes to Essential Genomic Players.Frontiers in genetics · 2021Review
- Partial pathogenicity chromosomes in Fusarium oxysporum are sufficient to cause disease and can be horizontally transferred.Environmental microbiology · 2020Article
- At the scene of the crime: New insights into the role of weakly pathogenic members of the fusarium head blight disease complex.Molecular plant pathology · 2020Article
- Accessory Chromosomes inPhytopathology · 2020Review
- Repeat-Induced Point Mutations Drive Divergence betweenPathogens (Basel, Switzerland) · 2019Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEukaryotes display remarkable genome plasticity, which can include supernumerary chromosomes that differ markedly from the core chromosomes. Despite the widespread occurrence of supernumerary chromosomes in fungi, their origin, relation to the core genome and the reason for their divergent characteristics are still largely unknown. The complexity of genome assembly due to the presence of repetitive DNA partially accounts for this.
resultsHere we use single-molecule real-time (SMRT) sequencing to assemble the genome of a prominent fungal wheat pathogen, Fusarium poae, including at least one supernumerary chromosome. The core genome contains limited transposable elements (TEs) and no gene duplications, while the supernumerary genome holds up to 25 % TEs and multiple gene duplications. The core genome shows all hallmarks of repeat-induced point mutation (RIP), a defense mechanism against TEs, specific for fungi. The absence of RIP on the supernumerary genome accounts for the differences between the two (sub)genomes, and results in a functional crosstalk between them. The supernumerary genome is a reservoir for TEs that migrate to the core genome, and even large blocks of supernumerary sequence (>200 kb) have recently translocated to the core. Vice versa, the supernumerary genome acts as a refuge for genes that are duplicated from the core genome.
conclusionsFor the first time, a mechanism was determined that explains the differences that exist between the core and supernumerary genome in fungi. Different biology rather than origin was shown to be responsible. A "living apart together" crosstalk exists between the core and supernumerary genome, accelerating chromosomal and organismal evolution.
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