ArticleAmerican journal of respiratory and critical care medicine2017
Obesity and Airway Dysanapsis in Children with and without Asthma.
Article in American journal of respiratory and critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04142905 (Is Asthma in Subjects With Obstructive Sleep Apnoea), which is not on this map. Cited by 152 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Is Asthma in Subjects With Obstructive Sleep Apnoea (OSA) Due to Dysanapsis
Who cites it
152 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Differential gene expression in nasal airway epithelium from overweight or obese youth with asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Pooled it
- Overweight, Obesity, and Lung Function in Children and Adults-A Meta-analysis.The journal of allergy and clinical immunology. In practicePooled it
- Obesity-Related Asthma: Structure and Inflammation.Current allergy and asthma reports · 2026Review
- Impact of a multidisciplinary intervention on resting and exercise respiratory functions in adolescents with obesity.Pediatric research · 2026Article
- Intrathoracic Adipose Tissue and Airway Structure, Lung Function, and Respiratory Symptoms: The Framingham Heart Study.medRxiv : the preprint server for health sciences · 2026Article
- Comparative predictive modeling of pediatric spirometry reference equations in Jordanian children: Complex versus simple models.PLOS digital health · 2026Article
- Early dysanapsis in experimental bronchopulmonary dysplasia: implications for lifelong lung disease.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Pulmonary function and physical fitness in obese children and adolescents: a comparison of impulse oscillometry, spirometry, and 6-min walk test.European journal of pediatrics · 2026Article
- Maternal and perinatal nutritional programming of lung health and disease in childhood and early adulthood: Research gaps and opportunities-National Heart, Lung, and Blood Institute/National Institutes of Health Workshop Report.The Journal of allergy and clinical immunology · 2026Article
- Article
- Mechanistic study of inspiratory training in childhood Asthma: Rationale and methods of a pediatric clinical trial.Contemporary clinical trials communications · 2026Article
- Adiposity measures and childhood asthma: one size does not fit all.Pediatric research · 2026Article
- Obesity and asthma: obesity causes and aggravates asthma across the entire type-2 inflammation spectrum.The European respiratory journal · 2026Review
- Phenotypic characterization of treatment-naïve childhood asthma with obesity: features of lung function, inflammation, and lipid profiles.European journal of pediatrics · 2026Article
- Overweight, obesity, adiposity measures, and asthma endotypes in Puerto Rican youth.American journal of respiratory and critical care medicine · 2026Article
- Childhood Environmental Exposures and Adult Disease.Pediatric pulmonology · 2026Review
- Assessment of ventilation distribution in overweight and obese children with asthma using electric impedance tomography: a cross-sectional study.Italian journal of pediatrics · 2026Article
- Quantifying the interaction between adiposity and hyperglycemia on incident asthma among youth.BMC public health · 2026Article
- The Developmental Origins of Asthma and COPD.Annual review of physiology · 2026Review
- Associations between body weight, asthma burden, and type 2 inflammation among under-resourced children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
92 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
Funding
Abstract
rationaleFor unclear reasons, obese children with asthma have higher morbidity and reduced response to inhaled corticosteroids.
objectivesTo assess whether childhood obesity is associated with airway dysanapsis (an incongruence between the growth of the lungs and the airways) and whether dysanapsis is associated with asthma morbidity.
methodsWe examined the relationship between obesity and dysanapsis in six cohorts of children with and without asthma, as well as the relationship between dysanapsis and clinical outcomes in children with asthma. Adjusted odds ratios (ORs) were calculated for each cohort and in a combined analysis of all cohorts; longitudinal analyses were also performed for cohorts with available data. Hazard ratios (HRs) for clinical outcomes were calculated for children with asthma in the Childhood Asthma Management Program. MEASUREMENTS AND MAIN
resultsBeing overweight or obese was associated with dysanapsis in both the cross-sectional (OR, 1.95; 95% confidence interval [CI], 1.62-2.35 [for overweight/obese compared with normal weight children]) and the longitudinal (OR, 4.31; 95% CI, 2.99-6.22 [for children who were overweight/obese at all visits compared with normal weight children]) analyses. Dysanapsis was associated with greater lung volumes (FVC, vital capacity, and total lung capacity) and lesser flows (FEV
conclusionsObesity is associated with airway dysanapsis in children. Dysanapsis is associated with increased morbidity among obese children with asthma and may partly explain their reduced response to inhaled corticosteroids.
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