Evidence map›Paper›PMID 27552258›Full record

ArticleClinical cardiology2016

Electrocardiographic Time to Intrinsicoid Deflection and Heart Failure: The Multi-Ethnic Study of Atherosclerosis.

Wesley T O'Neal, Waqas T Qureshi, Saman Nazarian, Nadine Kawel-Boehm, David A Bluemke, Joao A C Lima, Elsayed Z Soliman

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Delayed intrinsicoid deflection: Electrocardiographic harbinger of heart disease.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2022
    Review
  6. Article
  7. Electrical surrogate for detection of severe left ventricular systolic dysfunction.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2018
    Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Wesley T O'NealDepartment of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia. wesley.oneal@emory.edu.
Waqas T QureshiDepartment of Internal Medicine, Division of Cardiology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Saman NazarianSection for Cardiac Electrophysiology, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Nadine Kawel-BoehmDepartment of Radiology, Kantonsspital Graubuenden, Chur, Switzerland.
David A BluemkeDepartment of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, Maryland.
Joao A C LimaDepartment of Medicine, Division of Cardiology, and Department of Radiology, Johns Hopkins University, Baltimore, Maryland.
Elsayed Z SolimanDepartment of Internal Medicine, Division of Cardiology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Wake Forest University · USEmory University · USJohns Hopkins Medicine · USJohns Hopkins University · USKantonsspital Graubünden · CHNational Institutes of Health · US

Funding

SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTER-N01HC95159-268095159N01HC095159 · HC · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 1999 to 2006
$304k
NHLBI NIH HHS N01 HC095159
6 · The paper itself

Abstract

backgroundTime to intrinsicoid deflection (ID), the time from onset of the QRS complex to the peak of the R wave on the electrocardiogram, represents delayed ventricular activation and suggests that impaired myocardial function is present. It is unknown whether delayed time to ID is predictive of future heart failure (HF) events. HYPOTHESIS: Delayed time to ID is predictive of future HF events.

methodsA total of 6394 participants (mean age, 62 ± 10 years; 54% women; 38% whites, 28% blacks, 22% Hispanics, 12% Chinese Americans) without clinically apparent cardiovascular disease or major ventricular conduction delay (QRS ≥120 ms) from the Multi-Ethnic Study of Atherosclerosis were included. Time to ID was automatically measured from baseline electrocardiograms (2000-2002) as the maximum value in leads V5 and V6 . Cox regression was used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between time to ID and HF.

resultsOver a median follow-up of 11.2 years, a total of 217 (3.4%) participants developed HF (incidence rate per 1000 person-years: 3.33, 95% CI: 2.91-3.80). In a multivariable Cox regression analysis adjusted for demographics, cardiovascular risk factors, and potential confounders, each 10-ms increase in maximum time to ID was associated with an increased risk for HF (HR: 1.42, 95% CI: 1.15-1.74). The results remained similar when stratified by age, sex, and race/ethnicity.

conclusionsDelayed time to ID is able to identify individuals at risk for developing HF before major ventricular conduction delays (eg, bundle branch block) are evident.

Indexed as

Action PotentialsElectrocardiographyAgedAged, 80 and overChi-Square DistributionFemaleHeart BlockHeart Conduction SystemHeart FailureHeart RateHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisElectrocardiography ambulatory ECGEpidemiologyHeart failure/cardiac transplantation/cardiomyopathy/myocarditis

Identifiers

PMID27552258
PMCPMC5030133
OpenAlexW2508726793

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.