ArticlePloS one2016
Blood Reference Intervals for Preterm Low-Birth-Weight Infants: A Multicenter Cohort Study in Japan.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Machine learning techniques for predicting neurodevelopmental impairments in premature infants: a systematic review.Frontiers in artificial intelligence · 2025Pooled it
- Early Leukocyte Profiles in Preterm Infants Born to Mothers with Systemic Lupus Erythematosus: An Exploratory Matched Cohort Study.Children (Basel, Switzerland) · 2026Article
- Risk Factors Influencing Neurodevelopmental Outcome and Survival in Preterm Infants: A Prospective Cohort Study.Children (Basel, Switzerland) · 2026Article
- Regional Evidence on Neonatal Abstinence Syndrome: Association Between Finnegan Score Severity and Laboratory Findings in a Tertiary NICU.Healthcare (Basel, Switzerland) · 2026Article
- Human serum albumin: prediction model and reference values for preterm and term neonates.Pediatric research · 2026Article
- From Blood Count Parameters to ROP Risk: Early Hematological Predictors in Preterm Infants.Medicina (Kaunas, Lithuania) · 2025Article
- Changes in Liver Shear Wave Elastography of Preterm Infants during Hospitalization.American journal of perinatology · 2025Article
- Blood-Biomarkers for Glucose Metabolism in Preterm Infants.Biomedicines · 2023Article
- Risk factors for anemia of prematurity among 30-35-week preterm infants.Fukushima journal of medical science · 2023Article
- Machine learning prediction of gestational age from metabolic screening markers resistant to ambient temperature transportation: Facilitating use of this technology in low resource settings of South Asia and East Africa.Journal of global health · 2022Article
- Machine learning guided postnatal gestational age assessment using new-born screening metabolomic data in South Asia and sub-Saharan Africa.BMC pregnancy and childbirth · 2021Article
- Reference intervals for 26 common biochemical analytes in term neonates in Jilin Province, China.BMC pediatrics · 2021Article
- Vitamin K Deficiency Bleeding in Infancy.Nutrients · 2020Review
- Fetal Intraventricular Hemorrhage Due to Antiphospholipid Syndrome: A Case Report.Frontiers in pediatrics · 2020Article
- Hematologic Profiles of Ethiopian Preterm Infants With Clinical Diagnoses of Early-Onset Sepsis, Perinatal Asphyxia, and Respiratory Distress Syndrome.Global pediatric health · 2020Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preterm low-birth-weight infants remain difficult to manage based on adequate laboratory tests. The aim of this study was to establish blood reference intervals (RIs) in those newborns who were admitted to and survived in the neonatal intensive care unit (NICU). A multicenter prospective study was conducted among all infants admitted to 11 affiliated NICUs from 2010 to 2013. The clinical information and laboratory data were registered in a network database designed for this study. The RIs for 26 items were derived using the parametric method after applying the latent abnormal values exclusion method. The influence of birth weight (BW) and gestational age (GA) on the test results was expressed in terms of the standard deviation ratio (SDR), as SDRBW and SDRGA, respectively. A total of 3189 infants were admitted during the study period; 246 were excluded due to a lack of blood sampling data, and 234 were excluded for chromosomal abnormalities (n = 108), congenital anomalies requiring treatment with surgical procedures (n = 76), and death or transfer to another hospital (n = 50). As a result, 2709 infants were enrolled in this study. Both the SDRGA and SDRBW were above 0.4 in the test results for total protein (TP), albumin (ALB), alanine aminotransferase (ALT), and red blood cells (RBC); their values increased in proportion to the BW and GA. We derived 26 blood RIs for infants who were admitted to NICUs. These RIs should help in the performance of proper clinical assessments and research in the field of perinatal-neonatal medicine.
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