ArticleeLife2016
Behavioral-state modulation of inhibition is context-dependent and cell type specific in mouse visual cortex.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 160 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
160 citing papers in PubMed, 314 citations in OpenAlex.
- Article
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- Psilocybin reshapes cortical inhibition through selective interneuron recruitment.bioRxiv : the preprint server for biology · 2026Article
- Behavioural states control binocular vision through input-specific mechanisms.Nature communications · 2026Article
- Single-Cell Perturbations Reveal Selective Modulation of Causal Connectivity During Decision-Making.bioRxiv : the preprint server for biology · 2026Article
- Feature-tuned synaptic inputs to somatostatin interneurons drive context-dependent processing.Neuron · 2026Article
- Cortex-specific inversion of visual responses during sleep.bioRxiv : the preprint server for biology · 2026Article
- Nonlinear integration of sensory inputs and behavioral state by a single neuron in C. elegans.Current biology : CB · 2025Article
- Cortex-Wide Substrates for Body Schema and Action Awareness.bioRxiv : the preprint server for biology · 2025Article
- Delayed integration of somatostatin interneurons into visual circuits.Nature communications · 2025Article
- Feeding state-dependent neuropeptidergic modulation of reciprocally interconnected inhibitory neurons biases sensorimotor decisions in Drosophila.Nature communications · 2025Article
- Behavioral state and stimulus strength regulate the role of somatostatin interneurons in stabilizing network activity.Cell reports · 2025Article
- Characterization of iGABASnFR2 forNeurophotonics · 2025Article
- Brain region-specific gain modulation of place cells by VIP neurons.Nature communications · 2025Article
- State modulation in spatial networks with three interneuron subtypes.Science advances · 2025Article
- Disruptions in primary visual cortex physiology and function in a mouse model of Timothy syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Synaptic dynamics govern spatial integration in mouse visual cortex.bioRxiv : the preprint server for biology · 2025Article
- Integrating multimodal data to understand cortical circuit architecture and function.Nature neuroscience · 2025Review
- Cell-type-specific firing patterns in a V1 cortical column model depend on feedforward and feedback-driven states.PLoS computational biology · 2025Article
100 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Cortical responses to sensory stimuli are modulated by behavioral state. In the primary visual cortex (V1), visual responses of pyramidal neurons increase during locomotion. This response gain was suggested to be mediated through inhibitory neurons, resulting in the disinhibition of pyramidal neurons. Using in vivo two-photon calcium imaging in layers 2/3 and 4 in mouse V1, we reveal that locomotion increases the activity of vasoactive intestinal peptide (VIP), somatostatin (SST) and parvalbumin (PV)-positive interneurons during visual stimulation, challenging the disinhibition model. In darkness, while most VIP and PV neurons remained locomotion responsive, SST and excitatory neurons were largely non-responsive. Context-dependent locomotion responses were found in each cell type, with the highest proportion among SST neurons. These findings establish that modulation of neuronal activity by locomotion is context-dependent and contest the generality of a disinhibitory circuit for gain control of sensory responses by behavioral state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.