ReviewExpert opinion on drug safety2016
Surveillance monitoring for safety of in utero antiretroviral therapy exposures: current strategies and challenges.
Review in Expert opinion on drug safety, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01310023 (Surveillance Monitoring for ART Toxicities Study in HIV Uninfected Children Born to HIV Infected Women), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Surveillance Monitoring for ART Toxicities Study in HIV Uninfected Children Born to HIV Infected Women
Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Maternal Use of Integrase Strand Transfer Inhibitors During Pregnancy and Infant Neurodevelopment.JAMA network open · 2025Article
- The impact of free antiretroviral therapy for pregnant non-citizens and their infants in Botswana.Journal of the International AIDS Society · 2023Article
- Article
- Adverse pregnancy outcomes associated with antiretroviral therapy initiated before pregnancy and during pregnancy: a retrospective study in Hubei province, China.Frontiers in medicine · 2023Article
- Use of antiretroviral therapy in pregnancy and association with birth outcome among women living with HIV in Denmark: A nationwide, population-based cohort study.HIV medicine · 2022Article
- Dolutegravir in Pregnancy as Compared with Current HIV Regimens in the United States.The New England journal of medicine · 2022Article
- Pregnancy Outcomes in Pregnant Women with HIV on Tenofovir Disoproxil Fumarate (TDF) Compared to Tenofovir Alafenamide (TAF).Journal of AIDS and HIV treatment · 2022Article
- An International Prospective Cohort Study of HIV and Zika in Infants and Pregnancy (HIV ZIP): Study Protocol.Frontiers in global women's health · 2021Article
- Dolutegravir and pregnancy outcomes in women on antiretroviral therapy in Brazil: a retrospective national cohort study.The lancet. HIV · 2021Article
- Tenofovir alafenamide use in pregnant and lactating women living with HIV.Expert opinion on drug metabolism & toxicology · 2020Review
- Estimates of the global population of children who are HIV-exposed and uninfected, 2000-18: a modelling study.The Lancet. Global health · 2020Article
- Association of maternal antiretroviral use with microcephaly in children who are HIV-exposed but uninfected (SMARTT): a prospective cohort study.The lancet. HIV · 2020Article
- A hospital-based birth defects surveillance system in Kampala, Uganda.BMC pregnancy and childbirth · 2019Article
- Neural-Tube Defects and Antiretroviral Treatment Regimens in Botswana.The New England journal of medicine · 2019Article
- A hierarchical modeling approach for assessing the safety of exposure to complex antiretroviral drug regimens during pregnancy.Statistical methods in medical research · 2019Article
- Cardiac status of perinatally HIV-infected children: assessing combination antiretroviral regimens in observational studies.AIDS (London, England) · 2018Article
- In-utero exposure to antiretrovirals and neurodevelopment among HIV-exposed-uninfected children in Botswana.AIDS (London, England) · 2018Article
- Antiretroviral Treatment in HIV-1-Positive Mothers: Neurological Implications in Virus-Free Children.International journal of molecular sciences · 2017Review
- Optimizing Research Methods to Understand HIV-Exposed Uninfected Infant and Child Morbidity: Report of the Second HEU Infant and Child Workshop.Frontiers in immunology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 5 countries.
Funding
Abstract
introductionThe use of antiretroviral therapy (ART) in pregnancy to prevent vertical HIV transmission has been one of the most successful public health programs in the last decade. As a result, an unprecedented number of women are taking ART at conception and during pregnancy. Given few randomized studies evaluating safety of different ART regimens in pregnancy, ongoing drug safety surveillance is critical. Areas covered: This review aims to provide a rationale for ART drug safety surveillance, describe changing patterns of ART use and summarize current surveillance efforts in both low-resource and high-resource settings. Additionally, biostatistical approaches to and challenges in analysis of observational surveillance data are discussed. Expert opinion: The global landscape of ART use in pregnancy is rapidly increasing and evolving. Any increase in adverse effects of in-utero exposure to ART has the potential to reduce the impact of improvements in infant morbidity and mortality gained from decreased vertical HIV transmission. ART drug safety surveillance should therefore be a critical piece of programs to prevent mother to child transmission in both high- and low-resource settings. Current surveillance efforts could be strengthened with long-term follow-up of exposed children, pooling of data across cohorts and standardized approaches to analysis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.