Evidence map›Paper›PMID 27551991›Full record

ArticlePsychosomatic medicine

Replication of the Association of BDNF and MC4R Variants With Dietary Intake in the Diabetes Prevention Program.

Jeanne M McCaffery, Kathleen A Jablonski, Paul W Franks, Linda M Delahanty, Vanita Aroda, David Marrero, Richard F Hamman, Edward S Horton, Samuel Dagogo-Jack, Judith Wylie-Rosett and 6 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychosomatic medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00004992. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00004992 phase3completed

Diabetes Prevention Program

Ran1996Enrolled3,234Registered outcomes1Posted comparisons0ConditionsDiabetes Mellitus, Non-Insulin-Dependent, Glucose IntoleranceArmsIntensive lifestyle, Metformin, Placebo
PMID 11832527PMID 16855264other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 2 countries.

Jeanne M McCafferyFrom the Weight Control and Diabetes Research Center (McCaffery, Wing), The Miriam Hospital and Warren Alpert School of Medicine at Brown University, Providence, RI; The Biostatistics Center (Jablonski), The George Washington University, Rockville, MD; Genetic and Molecular Epidemiology Unit (Franks), Department of Clinical Sciences, Lund University, Malmo, Sweden; Department of Medicine, Umeå University, Umeå, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, MA; Massachusetts General Hospital Diabetes Center (Delahanty), Boston, MA; Department of Medicine, Harvard Medical School, Boston, MA; Medstar Health Research Institute (Aroda), Hyattsville, MD; Indiana University (Marrero), Indianapolis, IN; Colorado School of Public Health, Department of Epidemiology (Hamman), University of Colorado Denver, Aurora, CO; Joslin Diabetes Center (Horton), Boston, MA; University of Tennessee (Dagogo-Jack), Memphis, TN; Department of Epidemiology and Population Health (Wylie-Rosett), Albert Einstein College of Medicine, Bronx, NY; University of California San Diego (Barrett-Connor), La Jolla, CA; University of Pittsburgh (Kitabchi), Pittsburgh, PA; Diabetes Epidemiology and Clinical Research Section (Knowler), National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ; and Diabetes Research Center (Diabetes Unit) and Center for Human Genetic Research (Florez), Massachusetts General Hospital, Boston, MA; Department of Medicine, Harvard Medical School, Boston, MA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Kathleen A Jablonski
Paul W Franks
Linda M Delahanty
Vanita Aroda
David Marrero
Richard F Hamman
Edward S Horton
Samuel Dagogo-Jack
Judith Wylie-Rosett
Elizabeth Barrett-Connor
Abbas Kitabchi
William C Knowler
Rena R Wing
Jose C Florez
Diabetes Prevention Program Research Group
National Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

PRIMARY PREVENTION TRIAL--DATA COORDINATING CENTERU01DK048489 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI JABLONSKI, KATHLEEN ANN, TEMPROSA, MARINELLA · 1994 to 2021
$84.8M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
Core-010UL1TR001073 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, SHAMOON, HARRY · 2013 to 2017
$21.3M
Post-DDP Follow-up StudyU01DK048413 · NIDDK · UNIVERSITY OF WASHINGTON · PI KAHN, STEVEN EMANUEL · 1994 to 2021
$13.7M
PRIMARY PREVENTION TRIAL (DPT-2)U01DK048397 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI NATHAN, DAVID M · 1994 to 2021
$12.0M
NIDDM PRIMARY PREVENTION TRIAL (DPT 2)U01DK048404 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI LAFERRERE, BLANDINE B · 1994 to 2021
$11.6M
PRIMARY PREVENTION TRIAL (DPT-2)U01DK048339 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ARANETA, MARIA ROSARIO GORREZ, MUDALIAR, SUNDER · 1994 to 2022
$11.4M
NIDDM PRIMARY PREVENTION TRIALU01DK048412 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VENDITTI, ELIZABETH MARY · 1994 to 2021
$11.4M
PRIMARY PREVENTION TRIALU01DK048387 · NIDDK · MEDSTAR RESEARCH INSTITUTE · PI MAGEE, MICHELLE FISCHMANN · 1994 to 2022
$11.1M
TITLE OMITTEDU01DK048349 · NIDDK · YESHIVA UNIVERSITY · PI CRANDALL, JILL P · 1994 to 2021
$11.0M
PRIMARY PREVENTION TRIALU01DK048443 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WATSON, KAROL E · 1994 to 2021
$10.2M
NCATS NIH HHS UL1 TR001073NCATS NIH HHS UL1 TR001409NIDDK NIH HHS P30 DK017047NIDDK NIH HHS R01 DK072041NIDDK NIH HHS R01 DK078907NIDDK NIH HHS R01 DK090043NIDDK NIH HHS U01 DK048339NIDDK NIH HHS U01 DK048349NIDDK NIH HHS U01 DK048375NIDDK NIH HHS U01 DK048377NIDDK NIH HHS U01 DK048380NIDDK NIH HHS U01 DK048381NIDDK NIH HHS U01 DK048387NIDDK NIH HHS U01 DK048397NIDDK NIH HHS U01 DK048400NIDDK NIH HHS U01 DK048404NIDDK NIH HHS U01 DK048406NIDDK NIH HHS U01 DK048407NIDDK NIH HHS U01 DK048411NIDDK NIH HHS U01 DK048412NIDDK NIH HHS U01 DK048413NIDDK NIH HHS U01 DK048434NIDDK NIH HHS U01 DK048437NIDDK NIH HHS U01 DK048443NIDDK NIH HHS U01 DK048468NIDDK NIH HHS U01 DK048485NIDDK NIH HHS U01 DK048489NIDDK NIH HHS U01 DK048514
6 · The paper itself

Abstract

objectiveGenomewide association studies (GWAS) have identified consistent associations with obesity, with a number of studies implicating eating behavior as a primary mechanism. Few studies have replicated genetic associations with dietary intake. This study evaluates the association between obesity susceptibility loci and dietary intake.

methodsData were obtained as part of the Diabetes Prevention Program (DPP), a clinical trial of diabetes prevention in persons at high risk of diabetes. The association of 31 genomewide association studies identified obesity risk alleles with dietary intake, measured through a food frequency questionnaire, was investigated in 3,180 participants from DPP at baseline.

resultsThe minor allele at BDNF, identified as protective against obesity, was associated with lower total caloric intake (β = -106.06, SE = 33.13; p = .0014) at experimentwide statistical significance (p = .0016), whereas association of MC4R rs571312 with higher caloric intake reached nominal significance (β = 61.32, SE = 26.24; p = .0194). Among non-Hispanic white participants, the association of BDNF rs2030323 with total caloric intake was stronger (β = -151.99, SE = 30.09; p < .0001), and association of FTO rs1421085 with higher caloric intake (β = 56.72, SE = 20.69; p = .0061) and percentage fat intake (β = 0.37, SE = 0.08; p = .0418) was also observed.

conclusionsThese results demonstrate with the strength of independent replication that BDNF rs2030323 is associated with 100 to 150 greater total caloric intake per allele, with additional contributions of MC4R and, in non-Hispanic white individuals, FTO. As it has been argued that an additional 100 kcal/d could account for the trends in weight gain, prevention focusing on genetic profiles with high dietary intake may help to quell adverse obesity trends. CLINICAL

trial registrationClinicaltrials.gov,NCT00004992.

Indexed as

AdultAlpha-Ketoglutarate-Dependent Dioxygenase FTOBody Mass IndexBrain-Derived Neurotrophic FactorDiabetes MellitusEnergy IntakeFemaleGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedObesityReceptor, Melanocortin, Type 4White PeopleAlpha-Ketoglutarate-Dependent Dioxygenase FTOBrain-Derived Neurotrophic FactorFTO protein, humanMC4R protein, humanReceptor, Melanocortin, Type 4

Identifiers

PMID27551991
PMCPMC5285480
OpenAlexW2510923104

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.