Evidence map›Paper›PMID 27551891›Full record

ArticleChemical research in toxicology2016

Novel Organophosphate Ligand O-(2-Fluoroethyl)-O-(p-Nitrophenyl)Methylphosphonate: Synthesis, Hydrolytic Stability and Analysis of the Inhibition and Reactivation of Cholinesterases.

Chih-Kai Chao, S Kaleem Ahmed, John M Gerdes, Charles M Thompson

Abstract read
In one paragraph

Article in Chemical research in toxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. [The Journal of pharmacology and experimental therapeutics · 2024
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Divergent synthesis of organophosphate [Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2019
    Article
  7. Radiosynthesis of O-(1-[Journal of labelled compounds & radiopharmaceuticals · 2018
    Article
  8. Article
  9. An improved radiosynthesis of O-(2-[Journal of labelled compounds & radiopharmaceuticals · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Chih-Kai ChaoDepartment of Biomedical and Pharmaceutical Sciences, University of Montana , Missoula, Montana 59812, United States.
S Kaleem AhmedDepartment of Biomedical and Pharmaceutical Sciences, University of Montana , Missoula, Montana 59812, United States.
John M GerdesDepartment of Biomedical and Pharmaceutical Sciences, University of Montana , Missoula, Montana 59812, United States.
Charles M ThompsonDepartment of Biomedical and Pharmaceutical Sciences, University of Montana , Missoula, Montana 59812, United States.
University of Montana · USSouthern Research Institute · US

Funding

Molecular Imaging of Chemical Threats and CountermeasuresU01NS092495 · NINDS · UNIVERSITY OF MONTANA · PI GERDES, JOHN M, THOMPSON, CHARLES MARK · 2015 to 2019
$3.9M
In Vivo Pharmacokinetic and Pharmacodynamic Dispositions of Positron RadiolabeledR21NS072079 · NINDS · UNIVERSITY OF MONTANA · PI GERDES, JOHN M, THOMPSON, CHARLES MARK · 2010 to 2011
$695k
NINDS NIH HHS R21 NS072079NINDS NIH HHS U01 NS092495
6 · The paper itself

Abstract

The organophosphate O-(2-fluoroethyl)-O-(p-nitrophenyl) methyphosphonate 1 is the first-in-class, fluorine-18 radiolabeled organophosphate inhibitor ([

Indexed as

AnimalsCarbon-13 Magnetic Resonance SpectroscopyCholinesterase InhibitorsCholinesterase ReactivatorsCholinesterasesHumansHydrolysisLigandsOrganophosphorus CompoundsProton Magnetic Resonance SpectroscopySpectrometry, Mass, Electrospray IonizationCholinesterase InhibitorsCholinesterase ReactivatorsCholinesterasesLigandsmethylphosphonic acidOrganophosphorus Compounds

Identifiers

PMID27551891
PMCPMC5575788
OpenAlexW2511101415

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.