ArticleCentral European journal of urology2016
Melatonin protects kidney against apoptosis induced by acute unilateral ureteral obstruction in rats.
Article in Central European journal of urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 11 citations in OpenAlex.
- Melatonin prevents sepsis-induced renal injury via the PINK1/Parkin1 signaling pathway.International journal of molecular medicine · 2019Article
- Bioactive Compounds for the Treatment of Renal Disease.Yonsei medical journal · 2018Review
- Melatonin promoted renal regeneration in folic acid-induced acute kidney injury via inhibiting nucleocytoplasmic translocation of HMGB1 in tubular epithelial cells.American journal of translational research · 2017Article
- The multiple biological action potential of melatonin - is melatonin, mitochondria and the ischemic/reperfusion injury relationship essential in the pathogenesis of obstructive nephropathy?Central European journal of urology · 2016Article
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8 authors at 3 institutions in 1 country.
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Abstract
introductionTo investigate whether there was a protective effect of melatonin on apoptotic mechanisms after an acute unilateral obstruction of the kidney. MATERIAL AND
methodsA total of 25 rats consisting of five groups were used in the study, designated as follows: Group 1: control, Group 2: sham, Group 3: unilateral ureteral obstruction treated with only saline, Group 4: unilateral ureteral obstruction treated with melatonin immediately, and Group 5: unilateral obstruction treated with melatonin one day after obstruction. Melatonin was administered as a 10 mg/kg dose intraperitoneally. The kidneys were evaluated according to the apoptotic index and Ki-67 scores.
resultsComparison of all obstruction groups (Group 3, 4, and 5), revealed that the apoptotic index was significantly higher in Groups 1 and 2. Despite melatonin reduced apoptotic mechanisms in Groups 4 and 5, there was no significant difference between Groups 4 and 5 in terms of the reduction of apoptosis. However, the reduction of apoptosis in the melatonin treated group did not decrease to the level of Groups 1 and 2.
conclusionsDespite melatonin administration, which significantly reduces the apoptotic index occurring after acute unilateral ureteral obstruction, the present study did not observe a return to normal renal histology in the obstruction groups.
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