Evidence map›Paper›PMID 27551540›Full record

ReviewCell death discovery2016

Cardiac progenitor cells for heart repair.

Tyl Le, Jjh Chong

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell death discovery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Heart-derived endogenous stem cells.Molecular biology reports · 2025
    Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Extracellular vesicle therapeutics for cardiac repair.Journal of molecular and cellular cardiology · 2025
    Review
  13. Review
  14. Article
  15. Stem cells-derived exosomes as cardiac regenerative agents.International journal of cardiology. Heart & vasculature · 2024
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tyl LeCentre of Heart Research, Westmead Institute for Medical Research, The University of Sydney, Hawkesbury Road, Westmead, Sydney, New South Wale 2145, Australia; Department of Cardiology, Westmead Hospital, Hawkesbury Road, Westmead, Sydney, New South Wale 2145, Australia.
Jjh ChongCentre of Heart Research, Westmead Institute for Medical Research, The University of Sydney, Hawkesbury Road, Westmead, Sydney, New South Wale 2145, Australia; Department of Cardiology, Westmead Hospital, Hawkesbury Road, Westmead, Sydney, New South Wale 2145, Australia; Sydney Medical School, The University of Sydney, Sydney, New South Wale 2006, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cell therapy is being investigated as an innovative and promising strategy to restore cardiac function in patients with heart failure. Several stem cell populations, including adult (multipotent) stem cells from developed organs and tissues, have been tested for cardiac repair with encouraging clinical and pre-clinical results. The heart has been traditionally considered a post-mitotic organ, however, this view has recently changed with the identification of stem/progenitor cells residing within the adult heart. Given their cardiac developmental origins, these endogenous cardiac progenitor cells (CPCs) may represent better candidates for cardiac cell therapy compared with stem cells from other organs such as the bone marrow and adipose tissue. This brief review will outline current research into CPC populations and their cardiac repair/regenerative potential.

Identifiers

PMID27551540
PMCPMC4979410

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.