ArticleEcology and evolution2016
Dmrt1 polymorphism covaries with sex-determination patterns in Rana temporaria.
Article in Ecology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Gene Duplication, Translocation, and Molecular Evolution ofBiomolecules · 2025Article
- Sexual Dimorphic Expression ofSexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2025Article
- Divergent evolution of genetic sex determination mechanisms along environmental gradients.Evolution letters · 2023Article
- Testicular Transcriptome of Males and Pseudo-Males Provides Important New Insight into Sex Reversal ofAnimals : an open access journal from MDPI · 2022Article
- Chromosome genome assembly for the meagre,Frontiers in genetics · 2022Article
- European common frog (Ecology and evolution · 2021Article
- Sex-chromosome evolution in frogs: what role for sex-antagonistic genes?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Review
- A reciprocal translocation radically reshapes sex-linked inheritance in the common frog.Molecular ecology · 2019Article
- A rapid rate of sex-chromosome turnover and non-random transitions in true frogs.Nature communications · 2018Article
- Evolutionary and developmental dynamics of sex-biased gene expression in common frogs with proto-Y chromosomes.Genome biology · 2018Article
- Article
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Patterns of sex-chromosome differentiation and gonadal development have been shown to vary among populations of Rana temporaria along a latitudinal transect in Sweden. Frogs from the northern-boreal population of Ammarnäs displayed well-differentiated X and Y haplotypes, early gonadal differentiation, and a perfect match between phenotypic and genotypic sex. In contrast, no differentiated Y haplotypes could be detected in the southern population of Tvedöra, where juveniles furthermore showed delayed gonadal differentiation. Here, we show that Dmrt1, a gene that plays a key role in sex determination and sexual development across all metazoans, displays significant sex differentiation in Tvedöra, with a Y-specific haplotype distinct from Ammarnäs. The differential segment is not only much shorter in Tvedöra than in Ammarnäs, it is also less differentiated and associates with both delayed gonadal differentiation and imperfect match between phenotypic and genotypic sex. Whereas Tvedöra juveniles with a local Y haplotype tend to ultimately develop as males, those without it may nevertheless become functional XX males, but with strongly female-biased progeny. Our findings suggest that the variance in patterns of sex determination documented in common frogs might result from a genetic polymorphism within a small genomic region that contains Dmrt1. They also substantiate the view that recurrent convergences of sex determination toward a limited set of chromosome pairs may result from the co-option of small genomic regions that harbor key genes from the sex-determination pathway.
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