Evidence map›Paper›PMID 27551318›Full record

ArticleGenes & nutrition2016

Dibutyryl-cAMP affecting fat deposition of finishing pigs by decreasing the inflammatory system related to insulin sensitive or lipolysis.

Xianyong Ma, Wei Fang, Zongyong Jiang, Li Wang, Xuefen Yang, Kaiguo Gao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xianyong MaInstitute of Animal Science, Guangdong Academy of Agricultural Sciences, 510640 Guangzhou, China ; The Key Laboratory of Animal Nutrition and Feed Science (South China) of Ministry of Agriculture, 510640 Guangzhou, China ; State Key Laboratory of Livestock and Poultry Breeding, 510640 Guangzhou, China ; Guangdong Public Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China ; Guangdong Key Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China.
Wei FangInstitute of Animal Science, Guangdong Academy of Agricultural Sciences, 510640 Guangzhou, China ; The Key Laboratory of Animal Nutrition and Feed Science (South China) of Ministry of Agriculture, 510640 Guangzhou, China ; State Key Laboratory of Livestock and Poultry Breeding, 510640 Guangzhou, China ; Guangdong Public Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China ; Guangdong Key Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China.
Zongyong JiangInstitute of Animal Science, Guangdong Academy of Agricultural Sciences, 510640 Guangzhou, China ; The Key Laboratory of Animal Nutrition and Feed Science (South China) of Ministry of Agriculture, 510640 Guangzhou, China ; State Key Laboratory of Livestock and Poultry Breeding, 510640 Guangzhou, China ; Guangdong Public Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China ; Guangdong Key Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China.
Li WangInstitute of Animal Science, Guangdong Academy of Agricultural Sciences, 510640 Guangzhou, China ; The Key Laboratory of Animal Nutrition and Feed Science (South China) of Ministry of Agriculture, 510640 Guangzhou, China ; State Key Laboratory of Livestock and Poultry Breeding, 510640 Guangzhou, China ; Guangdong Public Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China ; Guangdong Key Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China.
Xuefen YangInstitute of Animal Science, Guangdong Academy of Agricultural Sciences, 510640 Guangzhou, China ; The Key Laboratory of Animal Nutrition and Feed Science (South China) of Ministry of Agriculture, 510640 Guangzhou, China ; State Key Laboratory of Livestock and Poultry Breeding, 510640 Guangzhou, China ; Guangdong Public Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China ; Guangdong Key Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China.
Kaiguo GaoInstitute of Animal Science, Guangdong Academy of Agricultural Sciences, 510640 Guangzhou, China ; The Key Laboratory of Animal Nutrition and Feed Science (South China) of Ministry of Agriculture, 510640 Guangzhou, China ; State Key Laboratory of Livestock and Poultry Breeding, 510640 Guangzhou, China ; Guangdong Public Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China ; Guangdong Key Laboratory of Animal Breeding and Nutrition, 510640 Guangzhou, China.
Guangdong Academy of Agricultural Sciences · CNMinistry of Agriculture and Rural Affairs · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe mechanism of db-cAMP regulating fat deposition and improving lean percentage is unclear and needs to be further studied.

methodsEighteen 100-day-old Duroc × Landrance × Large White barrows (49.75 ± 0.75 kg) were used for experiment 1, and 15 eighteen 135-day-old barrows (78.34 ± 1.22 kg) were used for experiment 2 to investigate the effects of dietary dibutyryl-cAMP (db-cAMP) on fat deposition in finishing pigs. Pigs were fed with a corn-soybean meal-based diet supplemented with 0 or 15 mg/kg db-cAMP, and both experiments lasted 35 days, respectively.

resultsThe results showed that db-cAMP decreased the backfat thickness, backfat percentage, and diameter of backfat cells without changing the growth performance or carcass characteristics in both experiments, and this effect was more marked in experiment 1 than in experiment 2; db-cAMP enhanced the activity of the growth hormone-insulin-like growth factor-1 (GH-IGF-1) axis and pro-opiomelanocortin (POMC) system in both experiments, which suppressed the accumulation of backfat deposition; microarray analysis showed that db-cAMP suppressed the inflammatory system within the adipose tissue related to insulin sensitivity, which also reduced fat synthesis.

conclusionsIn summary, the effect of db-cAMP on suppressing fat synthesis and accumulation is better in the earlier phase than in the later phase of finishing pigs, and db-cAMP plays this function by increasing the activity of the GH-IGF-1 axis and POMC system, while decreasing the inflammatory system within the adipose tissue related to insulin sensitive or lipolysis.

Indexed as

Adipocyte cellBackfat thicknessEndocrine systemGene microarrayInflammatory system

Identifiers

PMID27551318
PMCPMC4968439
OpenAlexW2415714832

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.