Evidence map›Paper›PMID 27551317›Full record

ArticleGenes & nutrition2016

The PBMC transcriptome profile after intake of oxidized versus high-quality fish oil: an explorative study in healthy subjects.

Mari C W Myhrstad, Inger Ottestad, Clara-Cecilie Günther, Einar Ryeng, Marit Holden, Astrid Nilsson, Kirsti W Brønner, Achim Kohler, Grethe I A Borge, Kirsten B Holven and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01034423 (Omega-3 Fatty Acids and Health Effects), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01034423 nacompletednot on this map

Omega-3 Fatty Acids and Health Effects

TypeinterventionalSponsorOslo Metropolitan UniversityRan2009 to 2009Enrolled69ConditionsHealthyArmsOmega-3, sun flower oil
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Mari C W MyhrstadDepartment of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, P.O. Box 4, St. Olavs plass, 0130 Oslo, Norway.
Inger OttestadDepartment of Nutrition, Institute for Basic Medical Sciences, University of Oslo, P.O. Box 1046, Blindern, 0317 Oslo, Norway ; Department of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, P.O. Box 4, St. Olavs plass, 0130 Oslo, Norway.
Clara-Cecilie GüntherNorwegian Computing Center, 0314 Oslo, Norway.
Einar RyengDepartment of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway.
Marit HoldenNorwegian Computing Center, 0314 Oslo, Norway.
Astrid NilssonNofima AS, Norwegian Institute of Food, Fisheries and Aquaculture Research, PB 210, Aas, N-1431 Norway.
Kirsti W BrønnerTINE SA, Centre for Research and Development, P.O. Box 7, Kalbakken, 0902 Oslo, Norway.
Achim KohlerNofima AS, Norwegian Institute of Food, Fisheries and Aquaculture Research, PB 210, Aas, N-1431 Norway ; Department of Mathematical Sciences and Technology (IMT), Norwegian University of Life Sciences, 1432 Ås, Norway.
Grethe I A BorgeNofima AS, Norwegian Institute of Food, Fisheries and Aquaculture Research, PB 210, Aas, N-1431 Norway.
Kirsten B HolvenDepartment of Nutrition, Institute for Basic Medical Sciences, University of Oslo, P.O. Box 1046, Blindern, 0317 Oslo, Norway ; Norwegian National Advisory Unit on Familial Hypercholesterolemia, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital Rikshospitalet, P.O Box 4950, Nydalen, Oslo, Norway.
Stine M UlvenDepartment of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, P.O. Box 4, St. Olavs plass, 0130 Oslo, Norway ; Department of Nutrition, Institute for Basic Medical Sciences, University of Oslo, P.O. Box 1046, Blindern, 0317 Oslo, Norway.
Nofima · NOUniversity of Oslo · NONorwegian Computing Center · NONorwegian University of Science and Technology · NOOsloMet – Oslo Metropolitan University · NOTine (Norway) · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMarine long-chain polyunsaturated fatty acids are susceptible to oxidation, generating a range of different oxidation products with suggested negative health effects. The aim of the present study was to utilize sensitive high-throughput transcriptome analyses to investigate potential unfavorable effects of oxidized fish oil (PV: 18 meq/kg; AV: 9) compared to high-quality fish oil (PV: 4 meq/kg; AV: 3).

methodsIn a double-blinded randomized controlled study for seven weeks, 35 healthy subjects were assigned to 8 g of either oxidized fish oil or high quality fish oil. The daily dose of EPA+DHA was 1.6 g. Peripheral blood mononuclear cells were isolated at baseline and after 7 weeks and transcriptome analyses were performed with the illuminaHT-12 v4 Expression BeadChip.

resultsNo gene transcripts, biological processes, pathway or network were significantly changed in the oxidized fish oil group compared to the fish oil group. Furthermore, gene sets related to oxidative stress and cardiovascular disease were not differently regulated between the groups. Within group analyses revealed a more prominent effect after intake of high quality fish oil as 11 gene transcripts were significantly (FDR < 0.1) changed from baseline versus three within the oxidized fish oil group.

conclusionThe suggested concern linking lipid oxidation products to short-term unfavorable health effects may therefore not be evident at a molecular level in this explorative study.

trial registrationClinicalTrials.gov, NCT01034423.

Indexed as

Human interventionn-3 fatty acidsOxidized fish oilPBMCsTranscriptome

Identifiers

PMID27551317
PMCPMC4968435
OpenAlexW2418246544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.