Evidence map›Paper›PMID 27551313›Full record

ReviewGenes & nutrition2016

Biomarkers for nutrient intake with focus on alternative sampling techniques.

T Holen, F Norheim, T E Gundersen, P Mitry, J Linseisen, P O Iversen, C A Drevon

Abstract readReview
In one paragraph

Review in Genes & nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Resveratrol supplementation improves metabolic control in rats with induced hyperlipidemia and type 2 diabetes.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019
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  19. Investigation of metabolites for estimating blood deposition time.International journal of legal medicine · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

T HolenDivision of Molecular Nutrition, Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, POB 1046, Blindern, 0317 Oslo, Norway.
F NorheimDepartment of Medicine/Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA USA.
T E GundersenVitas AS, Olso Innovation Park, Gaustadalleen 21, N-0349 Oslo, Norway.
P MitryInstitute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany.
J LinseisenInstitute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany.
P O IversenDivision of Molecular Nutrition, Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, POB 1046, Blindern, 0317 Oslo, Norway.
C A DrevonDivision of Molecular Nutrition, Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, POB 1046, Blindern, 0317 Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomarkers of nutrient intake or nutrient status are important objective measures of foods/nutrients as one of the most important environmental factors people are exposed to. It is very difficult to obtain accurate data on individual food intake, and there is a large variation of nutrient composition of foods consumed in a population. Thus, it is difficult to obtain precise measures of exposure to different nutrients and thereby be able to understand the relationship between diet, health, and disease. This is the background for investing considerable resources in studying biomarkers of nutrients believed to be important in our foods. Modern technology with high sensitivity and specificity concerning many nutrient biomarkers has allowed an interesting development with analyses of very small amounts of blood or tissue material. In combination with non-professional collection of blood by finger-pricking and collection on filters or sticks, this may make collection of samples and analyses of biomarkers much more available for scientists as well as health professionals and even lay people in particular in relation to the marked trend of self-monitoring of body functions linked to mobile phone technology. Assuming standard operating procedures are used for collection, drying, transport, extraction, and analysis of samples, it turns out that many analytes of nutritional interest can be measured like metabolites, drugs, lipids, vitamins, minerals, and many types of peptides and proteins. The advantage of this alternative sampling technology is that non-professionals can collect, dry, and mail the samples; the samples can often be stored under room temperature in a dry atmosphere, requiring small amounts of blood. Another promising area is the potential relation between the microbiome and biomarkers that may be measured in feces as well as in blood.

Indexed as

BiomarkersDietDried blood spots (DBS)LipidomicsMicrobiomeNutrients

Identifiers

PMID27551313
PMCPMC4968438

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.