Evidence map›Paper›PMID 27551008›Full record

ArticleAntimicrobial agents and chemotherapy2016

Successful Treatment of Bloodstream Infection Due to Metallo-β-Lactamase-Producing Stenotrophomonas maltophilia in a Renal Transplant Patient.

Maria F Mojica, Christopher P Ouellette, Amy Leber, M Brian Becknell, Monica I Ardura, Federico Perez, Masako Shimamura, Robert A Bonomo, Samuel L Aitken, Samuel A Shelburne

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 81 citations in OpenAlex.

  1. Review
  2. ComparativeAntimicrobial agents and chemotherapy · 2026
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  3. Article
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  5. Therapeutic challenges in managingFrontiers in cellular and infection microbiology · 2025
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  6. Candent issues in pneumonia. Reflections from the Fifth Annual Meeting of Spanish Experts 2023.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024
    Review
  7. JAC-antimicrobial resistance · 2024
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  8. Antibiotic Resistance and Virulence Factors in Clinical Isolates ofInternational journal of microbiology · 2024
    Article
  9. Article
  10. Article
  11. Successful Treatment of PersistentOpen forum infectious diseases · 2023
    Article
  12. Comparative genomics analysis ofFrontiers in cellular and infection microbiology · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Combination Therapy versus Monotherapy in the Treatment ofAntibiotics (Basel, Switzerland) · 2022
    Article
  17. Review
  18. Clinical challenges treatingJAC-antimicrobial resistance · 2022
    Review
  19. OvercomingOpen forum infectious diseases · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Maria F MojicaResearch Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Christopher P OuelletteDepartment of Pediatrics, Division of Pediatric Infectious Diseases, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio, USA.
Amy LeberDepartment of Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.
M Brian BecknellDepartment of Pediatrics, Division of Pediatric Nephrology, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio, USA.
Monica I ArduraDepartment of Pediatrics, Division of Pediatric Infectious Diseases, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio, USA.
Federico PerezResearch Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA Medical Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Masako ShimamuraDepartment of Pediatrics, Division of Pediatric Infectious Diseases, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio, USA Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA masako.shimamura@nationwidechildrens.org robert.bonomo@va.gov sshelburne@mdanderson.org.
Robert A BonomoResearch Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA Medical Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA masako.shimamura@nationwidechildrens.org robert.bonomo@va.gov sshelburne@mdanderson.org.
Samuel L AitkenDivision of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Samuel A ShelburneDepartment of Infectious Diseases, Infection Control, and Employee Health, and Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA masako.shimamura@nationwidechildrens.org robert.bonomo@va.gov sshelburne@mdanderson.org.
The Ohio State University · USNationwide Children's Hospital · USThe University of Texas MD Anderson Cancer Center · USUniversity School · USLouis Stokes Cleveland VA Medical Center · US

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Understanding B-Lactam Resistance in Acinetobacter baumanniiR01AI072219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ROBERT A. BONOMO, Philip N. Rather · 2007 to 2026
$6.6M
Understanding ceftazidime resistance in SHV B-LactamasesR01AI063517 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A. · 2005 to 2023
$4.9M
A Mechanism-Based Approach to Metallo-beta-Lactamase InhibitionR01AI100560 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A., SPENCER, JAMES · 2012 to 2022
$4.4M
Innate Immunity and Viral Renal Allograft InjuryR01AI101138 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SHIMAMURA, MASAKO · 2013 to 2017
$1.8M
The Continuing Challenge of Carbapenemases in K. pneumoniae: KPC-2 & NDM-1I01BX001974 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI BONOMO, ROBERT A. · 2013 to 2024
–
BLRD VA I01 BX001974NCATS NIH HHS UL1 TR000439NIAID NIH HHS R01 AI063517NIAID NIH HHS R01 AI072219NIAID NIH HHS R01 AI100560NIAID NIH HHS R01 AI101138
6 · The paper itself

Abstract

Stenotrophomonas maltophilia is an emerging multidrug-resistant (MDR) opportunistic pathogen for which new antibiotic options are urgently needed. We report our clinical experience treating a 19-year-old renal transplant recipient who developed prolonged bacteremia due to metallo-β-lactamase-producing S. maltophilia refractory to conventional treatment. The infection recurred despite a prolonged course of colistimethate sodium (colistin) but resolved with the use of a novel drug combination with clinical efficacy against the patient's S. maltophilia isolate.

Indexed as

Kidney TransplantationAnti-Bacterial AgentsAzabicyclo CompoundsAztreonamBacteremiabeta-LactamasesCeftazidimeColistinDrug CombinationsDrug Resistance, Multiple, BacterialDrug SubstitutionGene ExpressionGram-Negative Bacterial InfectionsHumansMalePolycystic Kidney DiseasesAnti-Bacterial Agentsavibactam, ceftazidime drug combinationAzabicyclo CompoundsAztreonambeta-LactamasesCeftazidimeColistinDrug Combinations

Identifiers

PMID27551008
PMCPMC4997835
OpenAlexW2507979690

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.