ArticleMolecular psychiatry2017
CRF receptor type 2 neurons in the posterior bed nucleus of the stria terminalis critically contribute to stress recovery.
Article in Molecular psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 86 citations in OpenAlex.
- CRH neurons in the dorsal bed nucleus of the stria terminalis (dBNST) mediate contextual fear generalization.Neurobiology of stress · 2026Article
- Chemogenetic modulation of CRF neurons in the BNST compensates for phenotypic behavioral differences in fear extinction learning of 5-HT2C receptor mutant mice.Translational psychiatry · 2026Article
- Suppression of Luteinizing Hormone Secretion in Female Mice by a Urocortin 2-CRHR2 Signaling Pathway.Endocrinology · 2025Article
- Single Intranasal Administration of Ucn3 Affects the Development of PTSD Symptoms in an Animal Model.International journal of molecular sciences · 2024Article
- Prefrontal projections to the bed nuclei of the stria terminalis modulate the specificity of aversive memories.Research square · 2024Article
- Hyperexcitation of ovBNST CRF neurons during stress contributes to female-biased expression of anxiety-like avoidance behaviors.Science advances · 2024Article
- The role and mechanism of 5-HTDRN-BNST neural circuit in anxiety and fear lesions.Frontiers in neuroscience · 2024Review
- SIRT1 in the BNST modulates chronic stress-induced anxiety of male mice via FKBP5 and corticotropin-releasing factor signaling.Molecular psychiatry · 2023Article
- Neurons innervating both the central amygdala and the ventral tegmental area encode different emotional valences.Frontiers in neuroscience · 2023Article
- Aberrant ventral dentate gyrus structure and function in trauma susceptible mice.Translational psychiatry · 2022Article
- Neural correlates of beneficial effects of young plasma treatment in aged mice: PET-SPM analyses and neuro-behavioural/molecular biological studies.European journal of nuclear medicine and molecular imaging · 2022Article
- Female-specific role of ciliary neurotrophic factor in the medial amygdala in promoting stress responses.Neurobiology of stress · 2022Article
- Corticotropin-releasing factor induces functional and structural synaptic remodelling in acute stress.Translational psychiatry · 2021Article
- Npas4a expression in the teleost forebrain is associated with stress coping style differences in fear learning.Scientific reports · 2021Article
- Corticotropin Releasing Hormone Signaling in the Bed Nuclei of the Stria Terminalis as a Link to Maladaptive Behaviors.Frontiers in neuroscience · 2021Review
- Expression Patterns of the Neuropeptide Urocortin 3 and Its Receptor CRFR2 in the Mouse Central Auditory System.Frontiers in neural circuits · 2021Article
- Chemoarchitecture of the bed nucleus of the stria terminalis: Neurophenotypic diversity and function.Handbook of clinical neurology · 2021Review
- Early-life stress alters affective behaviors in adult mice through persistent activation of CRH-BDNF signaling in the oval bed nucleus of the stria terminalis.Translational psychiatry · 2020Article
- Role of corticotropin-releasing factor in alcohol and nicotine addiction.Brain research · 2020Review
- Bed nuclei of the stria terminalis modulate memory consolidation via glucocorticoid-dependent and -independent circuits.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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Authors and funding
13 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bed nucleus of the stria terminalis (BNST) is critical in mediating states of anxiety, and its dysfunction has been linked to stress-related mental disease. Although the anxiety-related role of distinct subregions of the anterior BNST was recently reported, little is known about the contribution of the posterior BNST (pBNST) to the behavioral and neuroendocrine responses to stress. Previously, we observed abnormal expression of corticotropin-releasing factor receptor type 2 (CRFR2) to be associated with post-traumatic stress disorder (PTSD)-like symptoms. Here, we found that CRFR2-expressing neurons within the pBNST send dense inhibitory projections to other stress-related brain regions (for example, the locus coeruleus, medial amygdala and paraventricular nucleus), implicating a prominent role of these neurons in orchestrating the neuroendocrine, autonomic and behavioral response to stressful situations. Local CRFR2 activation by urocortin 3 depolarized the cells, increased the neuronal input resistance and increased firing of action potentials, indicating an enhanced excitability. Furthermore, we showed that CRFR2-expressing neurons within the pBNST are critically involved in the modulation of the behavioral and neuroendocrine response to stress. Optogenetic activation of CRFR2 neurons in the pBNST decreased anxiety, attenuated the neuroendocrine stress response, ameliorated stress-induced anxiety and impaired the fear memory for the stressful event. Moreover, activation following trauma exposure reduced the susceptibility for PTSD-like symptoms. Optogenetic inhibition of pBNST CRFR2 neurons yielded opposite effects. These data indicate the relevance of pBNST activity for adaptive stress recovery.
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