SynthesisCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2016
Genetic Risk Score Mendelian Randomization Shows that Obesity Measured as Body Mass Index, but not Waist:Hip Ratio, Is Causal for Endometrial Cancer.
Open access · bronzeAbstract readMeta-AnalysisMulticenter Study
In one paragraph
Synthesis in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
7.7field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis.BMC medicine · 2022Pooled it
- Systematic review of Mendelian randomization studies on risk of cancer.BMC medicine · 2022Pooled it
- Obesity and gynaecological and obstetric conditions: umbrella review of the literature.BMJ (Clinical research ed.) · 2017Pooled it
- Risk stratification for endometrial cancer: independent and joint effects of polygenic risk score and body mass index in 129,829 UK Biobank participants.BMC medicine · 2026Observational
- An intriguing journey into the hereditary syndromes predisposing to endometrial cancer: more than believed.Therapeutic advances in medical oncology · 2026Review
- Adiposity distribution and risks of 12 obesity-related cancers: a Mendelian randomization analysis.Journal of the National Cancer Institute · 2025Article
- Adiposity, metabolites and endometrial cancer risk: inference from combinations of Mendelian randomization and observational analyses.BMC cancer · 2025Observational
- The Effect of Circulating Proteins and Their Role in Mediating Adiposity's Effect on Endometrial Cancer Risk: Mendelian Randomization and Colocalization Analyses.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Germline copy number variants and endometrial cancer risk.Human genetics · 2024Article
- Exploring potential causal genetic variants and genes for endometrial cancer: Open Targets Genetics, Mendelian randomization, and multi-tissue transcriptome-wide association analysis.Translational cancer research · 2024Article
- Unraveling the causal association between lifestyle and metabolic factors with endometrial cancer: evidence from a Mendelian randomization study.Discover oncology · 2024Article
- Exploring the interaction mechanisms between cervical carcinoma in situ and antibody-mediated immune responses through Mendelian randomization analysis.Discover oncology · 2024Article
- Burden of uterine cancer in China from 1990 to 2021 and 15-year projection: a systematic analysis and comparison with global levels.Reproductive health · 2024Article
- Using Genetics to Investigate Relationships between Phenotypes: Application to Endometrial Cancer.Genes · 2024Review
- The causal effects of genetically predicted alcohol consumption on endometrial cancer risk from a Mendelian randomization study.Scientific reports · 2024Article
- A comprehensive analysis of immunotherapy in advanced endometrial cancer (Review).Oncology letters · 2024Review
- Multi-trait genome-wide association study identifies a novel endometrial cancer risk locus that associates with testosterone levels.iScience · 2023Article
- Article
- Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk.BMC medicine · 2022Article
- Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study.Journal of the National Cancer Institute · 2022Article
Corrections and comments
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Authors and funding
76 authors at 20 institutions in 7 countries.
Jodie N PainterDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Tracy A O'MaraDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Louise MarquartDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Penelope M Webb
John AttiaHunter Medical Research Institute, John Hunter Hospital, Newcastle, Australia.
Sarah E MedlandDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Timothy ChengWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Joe DennisDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Elizabeth G HollidayHunter Medical Research Institute, John Hunter Hospital, Newcastle, Australia.
Mark McEvoyCentre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Australia.
Rodney J ScottHunter Medical Research Institute, John Hunter Hospital, Newcastle, Australia.
Shahana AhmedDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Catherine S HealeyDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Mitul ShahDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Maggie GormanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Lynn MartinWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Shirley V HodgsonDepartment of Clinical Genetics, St George's, University of London, London, United Kingdom.
Matthias W BeckmannDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Arif B EkiciInstitute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
Peter A FaschingDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Alexander HeinDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Matthias RübnerDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Kamila CzeneDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Hatef DarabiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Jingmei LiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Thilo DörkHannover Medical School, Gynaecology Research Unit, Hannover, Germany.
Matthias DürstDepartment of Gynaecology, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
Peter HillemannsHannover Medical School, Clinics of Gynaecology and Obstetrics, Hannover, Germany.
Ingo B RunnebaumDepartment of Gynaecology, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
Frederic AmantDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals, KU Leuven - University of Leuven, Leuven, Belgium.
Daniela AnnibaliDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals, KU Leuven - University of Leuven, Leuven, Belgium.
Jeroen DepreeuwDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals, KU Leuven - University of Leuven, Leuven, Belgium.
Diether LambrechtsVesalius Research Center, VIB, Leuven, Belgium.
Patrick NevenDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals, KU Leuven - University of Leuven, Leuven, Belgium.
Julie M CunninghamDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
Sean C DowdyDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mayo Clinic, Rochester, Minnesota.
Ellen L GoodeDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Brooke L FridleyDepartment of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas.
Stacey J WinhamDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Tormund S NjølstadDepartment of Clinical Science, Centre for Cancer Biomarkers, The University of Bergen, Bergen, Norway.
Helga B SalvesenDepartment of Clinical Science, Centre for Cancer Biomarkers, The University of Bergen, Bergen, Norway.
Jone TrovikDepartment of Clinical Science, Centre for Cancer Biomarkers, The University of Bergen, Bergen, Norway.
Henrica M J WernerDepartment of Clinical Science, Centre for Cancer Biomarkers, The University of Bergen, Bergen, Norway.
Katie A AshtonHunter Medical Research Institute, John Hunter Hospital, Newcastle, Australia.
Geoffrey OttonSchool of Medicine and Public Health, University of Newcastle, Newcastle, Australia.
Anthony ProiettoSchool of Medicine and Public Health, University of Newcastle, Newcastle, Australia.
Miriam MintsDepartment of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Emma Tham
Manjeet K BollaDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Kyriaki MichailidouDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Qin WangDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Jonathan P TyrerDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia.
Julian PetoLondon School of Hygiene and Tropical Medicine, London, United Kingdom.
Anthony J SwerdlowDivision of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom.
Barbara BurwinkelDepartment of Gynecology and Obstetrics, Molecular Biology of Breast Cancer, University of Heidelberg, Heidelberg, Germany.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Alfons MeindlDepartment of Obstetrics and Gynecology, Division of Tumor Genetics, Technical University of Munich, Munich, Germany.
Hiltrud BrauchGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Annika LindblomDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Fergus J CouchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
Graham G GilesCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia.
Vessela N KristensenDepartment of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway.
Angela CoxSheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, United Kingdom.
Paul D P PharoahDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Ian TomlinsonWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Alison M DunningDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Douglas F EastonDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Deborah J Thompson
Amanda B Spurdle
AOCS Group
for RENDOCAS
National Study of Endometrial Cancer Genetics Group (NSECG)
Australian National Endometrial Cancer Study Group (ANECS)
Cancer Research UK Cambridge Center · GBQIMR Berghofer Medical Research Institute · AUKarolinska Institutet · SECentre for Human Genetics · GBFriedrich-Alexander-Universität Erlangen-Nürnberg · DEHaukeland University Hospital · NOJohn Hunter Hospital · AUGerman Cancer Research Center · DEKU Leuven · BEMayo Clinic · USUniversity of Newcastle Australia · AUCenter for Human Genetics · USFriedrich Schiller University Jena · DEKarolinska University Hospital · SEMayo Clinic in Florida · USMedizinische Hochschule Hannover · DEThe University of Melbourne · AUBreast Cancer Now · GBSt George's, University of London · GBTechnical University of Munich · DE
Funding
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3MTRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5MUse of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI ELLEN L. GOODE · 2009 to 2026
$37.0MEpidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6MEpidemiological and Clinical Translational Studies Post Genome-Wide AssociationU19CA148537 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EASTON, DOUGLAS FREDERICK, EELES, ROSALIND · 2010 to 2014
$10.4MOvarian cancer GWAS discovery, expansion and replication (N2 - Project #1)U19CA148112 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI SELLERS, THOMAS A · 2010 to 2014
$10.2MA genome-wide association study for breast cancer in BRCA1 mutation carriersR01CA128978 · NCI · MAYO CLINIC ROCHESTER · PI COUCH, FERGUS JOSEPH · 2008 to 2012
$4.8MGenetic Variation in the NF-kappaB Pathway and Ovarian Cancer EtiologyR01CA122443 · NCI · MAYO CLINIC ROCHESTER · PI GOODE, ELLEN L. · 2007 to 2012
$2.7MCancer Research UK 10118Cancer Research UK 10119Cancer Research UK 10124Cancer Research UK 16459Cancer Research UK 16561Cancer Research UK 16565NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA076292NCI NIH HHS P50 CA136393NCI NIH HHS R01 CA122443NCI NIH HHS R01 CA128978NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148537Wellcome Trust
Abstract
backgroundThe strongest known risk factor for endometrial cancer is obesity. To determine whether SNPs associated with increased body mass index (BMI) or waist-hip ratio (WHR) are associated with endometrial cancer risk, independent of measured BMI, we investigated relationships between 77 BMI and 47 WHR SNPs and endometrial cancer in 6,609 cases and 37,926 country-matched controls.
methodsLogistic regression analysis and fixed effects meta-analysis were used to test for associations between endometrial cancer risk and (i) individual BMI or WHR SNPs, (ii) a combined weighted genetic risk score (wGRS) for BMI or WHR. Causality of BMI for endometrial cancer was assessed using Mendelian randomization, with BMIwGRS as instrumental variable.
resultsThe BMIwGRS was significantly associated with endometrial cancer risk (P = 3.4 × 10
conclusionsBMI, but not WHR, is causally associated with endometrial cancer risk, with evidence that some BMI-associated SNPs alter endometrial cancer risk via mechanisms other than measurable BMI. IMPACT: The causal association between BMI SNPs and endometrial cancer has possible implications for endometrial cancer risk modeling. Cancer Epidemiol Biomarkers Prev; 25(11); 1503-10. ©2016 AACR.
Indexed as
Body Mass IndexGenetic Predisposition to DiseaseMendelian Randomization AnalysisPolymorphism, Single NucleotideEndometrial NeoplasmsFemaleHumansObesityWaist-Hip Ratio
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