Evidence map›Paper›PMID 27550654›Full record

ArticleEuropean journal of drug metabolism and pharmacokinetics2017

Characterization of the Biodistribution and Systemic Absorption of TT-173, a New Hemostatic Agent of Recombinant Human Tissue Factor, Using Radiolabeling with 18F.

Santiago Rojas, José Raúl Herance, Juan Domingo Gispert, Belén Arias, Ignasi Miquel, Ramón López, Pilar Sánchez, Esther Rincón, Jesús Murat

Abstract read
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In one paragraph

Article in European journal of drug metabolism and pharmacokinetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Santiago RojasThrombotargets Europe S.L., Mediterranean Technology Park, Av. Canal Olímpic, s/n, Edif, B 6, 2ª, Castelldefels, 08860, Barcelona, Spain. santiagorojas@thrombotargets.com.
José Raúl HeranceMolecular Imaging Research Group-Vall d'Hebron Research Institute, CIBBIM-Nanomedicine, Barcelona, Spain. raul.herance@vhir.org.
Juan Domingo GispertBarcelonabeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.
Belén AriasThrombotargets Europe S.L., Mediterranean Technology Park, Av. Canal Olímpic, s/n, Edif, B 6, 2ª, Castelldefels, 08860, Barcelona, Spain.
Ignasi MiquelThrombotargets Europe S.L., Mediterranean Technology Park, Av. Canal Olímpic, s/n, Edif, B 6, 2ª, Castelldefels, 08860, Barcelona, Spain.
Ramón LópezThrombotargets Europe S.L., Mediterranean Technology Park, Av. Canal Olímpic, s/n, Edif, B 6, 2ª, Castelldefels, 08860, Barcelona, Spain.
Pilar SánchezThrombotargets Europe S.L., Mediterranean Technology Park, Av. Canal Olímpic, s/n, Edif, B 6, 2ª, Castelldefels, 08860, Barcelona, Spain.
Esther RincónThrombotargets Europe S.L., Mediterranean Technology Park, Av. Canal Olímpic, s/n, Edif, B 6, 2ª, Castelldefels, 08860, Barcelona, Spain.
Jesús MuratThrombotargets Europe S.L., Mediterranean Technology Park, Av. Canal Olímpic, s/n, Edif, B 6, 2ª, Castelldefels, 08860, Barcelona, Spain.
Thrombotargets (Spain) · ESBarcelonaβeta Brain Research Center · ESUniversitat Autònoma de Barcelona · ESVall d'Hebron Institut de Recerca · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesTT-173 is the first topical hemostatic agent based on tissue factor. To prevent thromboembolic events and intravascular coagulation it is necessary to rule out the systemic absorption of new bioactive hemostats. Here, we radiolabeled TT-173 with [

methodsA group of rats were administered intravenously with [

resultsAfter topical application, low amounts of [

conclusionsAfter topical application, [

Indexed as

Absorption, PhysiologicalAdministration, TopicalAnimalsBiological TransportFluorine RadioisotopesHemostaticsHumansImage Processing, Computer-AssistedInjections, IntravenousMaleModels, BiologicalPositron-Emission TomographyRadiopharmaceuticalsRats, Sprague-DawleySkinThromboplastinFluorine RadioisotopesHemostaticsRadiopharmaceuticalsThromboplastin

Identifiers

PMID27550654
OpenAlexW2509195587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.