Evidence map›Paper›PMID 27550478›Full record

GuidelineJournal of Korean medical science2016

Clinical Practice Guidelines for the Management of Atypical Hemolytic Uremic Syndrome in Korea.

Hae Il Cheong, Sang Kyung Jo, Sung Soo Yoon, Heeyeon Cho, Jin Seok Kim, Young Ok Kim, Ja Ryong Koo, Yong Park, Young Seo Park, Jae Il Shin and 2 more

Open access · goldAbstract readPractice Guideline
In one paragraph

Guideline in Journal of Korean medical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Guideline
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 2 countries.

Hae Il CheongDepartment of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.ORCID http://orcid.org/0000-0001-7556-1265
Sang Kyung JoDivision of Nephrology, Department of Internal Medicine, Korea University School of Medicine, Seoul, Korea.ORCID http://orcid.org/0000-0002-0496-0258
Sung Soo YoonDepartment of Internal Medicine, Seoul National University, Seoul, Korea.ORCID http://orcid.org/0000-0003-2591-7459
Heeyeon ChoDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID http://orcid.org/0000-0003-3137-6054
Jin Seok KimDivision of Hematology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea.ORCID http://orcid.org/0000-0001-8986-8436
Young Ok KimDepartment of Internal Medicine, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea.ORCID http://orcid.org/0000-0001-8131-7998
Ja Ryong KooDivision of Nephrology, Dongtan Sacred Heart Hospital, Hallym University Medical Center, Hwaseong, Korea.ORCID http://orcid.org/0000-0003-4245-2569
Yong ParkDivision of Hematology, Department of Internal Medicine, Korea University School of Medicine, Seoul, Korea.ORCID http://orcid.org/0000-0001-7909-6639
Young Seo ParkDepartment of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.ORCID http://orcid.org/0000-0001-7653-2036
Jae Il ShinDepartment of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID http://orcid.org/0000-0003-2326-1820
Kee Hwan YooDepartment of Pediatrics, Korea University Guro Hospital, Seoul, Korea.ORCID http://orcid.org/0000-0001-6490-4293
Doyeun OhDepartment of Internal Medicine, School of Medicine, CHA University, Seongnam, Korea. doh@cha.ac.kr.ORCID http://orcid.org/0000-0002-6981-3144
Ulsan College · KRYonsei University · KRCatholic University of Korea · KRCHA University · KRHallym University Dongtan Sacred Heart Hospital · KRKorea University · KRKorea University Medical Center · KRSamsung Medical Center · KRSeoul National University · KRSeoul National University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atypical hemolytic uremic syndrome (aHUS) is a rare syndrome characterized by micro-angiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. The major pathogenesis of aHUS involves dysregulation of the complement system. Eculizumab, which blocks complement C5 activation, has recently been proven as an effective agent. Delayed diagnosis and treatment of aHUS can cause death or end-stage renal disease. Therefore, a diagnosis that differentiates aHUS from other forms of thrombotic microangiopathy is very important for appropriate management. These guidelines aim to offer recommendations for the diagnosis and treatment of patients with aHUS in Korea. The guidelines have largely been adopted from the current guidelines due to the lack of evidence concerning the Korean population.

Indexed as

Blood TransfusionOrgan TransplantationAcute Kidney InjuryADAMTS13 ProteinAntibodies, Monoclonal, HumanizedAtypical Hemolytic Uremic SyndromeComplement Factor HComplement System ProteinsDelayed DiagnosisHumansKidney Failure, ChronicRepublic of KoreaADAMTS13 ProteinAntibodies, Monoclonal, HumanizedComplement Factor HComplement System ProteinseculizumabAtypical Hemolytic Uremic SyndromeDiagnosisGuidelinesTreatment

Identifiers

PMID27550478
PMCPMC4999392
OpenAlexW2510454665

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.