Evidence map›Paper›PMID 27550069›Full record

Trial reportJournal of the Association for Research in Otolaryngology : JARO2016

Effect of Contralateral Medial Olivocochlear Feedback on Perceptual Estimates of Cochlear Gain and Compression.

Mark D Fletcher, Katrin Krumbholz, Jessica de Boer

Abstract readClinical Trial
In one paragraph

Trial report in Journal of the Association for Research in Otolaryngology : JARO, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Evidence for Gain Reduction by a Precursor in an On-Frequency Forward Masking Paradigm.Acta acustica united with acustica : the journal of the European Acoustics Association (EEIG)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mark D FletcherMedical Research Council Institute of Hearing Research, The University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Katrin KrumbholzMedical Research Council Institute of Hearing Research, The University of Nottingham, University Park, Nottingham, NG7 2RD, UK. katrin@ihr.mrc.ac.uk.ORCID http://orcid.org/0000-0001-8297-2628
Jessica de BoerMedical Research Council Institute of Hearing Research, The University of Nottingham, University Park, Nottingham, NG7 2RD, UK.

Funding

Medical Research Council MC_U135097128Medical Research Council MC_UU_00010/2
6 · The paper itself

Abstract

The active cochlear mechanism amplifies responses to low-intensity sounds, compresses the range of input sound intensities to a smaller output range, and increases cochlear frequency selectivity. The gain of the active mechanism can be modulated by the medial olivocochlear (MOC) efferent system, creating the possibility of top-down control at the earliest level of auditory processing. In humans, MOC function has mostly been measured by the suppression of otoacoustic emissions (OAEs), typically as a result of MOC activation by a contralateral elicitor sound. The exact relationship between OAE suppression and cochlear gain reduction, however, remains unclear. Here, we measured the effect of a contralateral MOC elicitor on perceptual estimates of cochlear gain and compression, obtained using the established temporal masking curve (TMC) method. The measurements were taken at a signal frequency of 2 kHz and compared with measurements of click-evoked OAE suppression. The elicitor was a broadband noise, set to a sound pressure level of 54 dB to avoid triggering the middle ear muscle reflex. Despite its low level, the elicitor had a significant effect on the TMCs, consistent with a reduction in cochlear gain. The amount of gain reduction was estimated as 4.4 dB on average, corresponding to around 18 % of the without-elicitor gain. As a result, the compression exponent increased from 0.18 to 0.27.

Indexed as

Diagnostic Techniques, OtologicalAdultCochleaFemaleHumansMaleReflex, AcousticVestibulocochlear NerveYoung Adultclick-evoked otoacoustic emissions (CEOAEs)cochlear amplificationcontralateral acoustic stimulationmedial olivocochlear reflex (MOCR)temporal masking curve (TMC)

Identifiers

PMID27550069
PMCPMC5112214

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.