ArticleNature communications2016
Chirality imprinting and direct asymmetric reaction screening using a stereodynamic Brønsted/Lewis acid receptor.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Stereodynamic Helicenes for Chirality Sensing and Enantiomeric Assay through Diastereomeric Helical Enrichment.JACS Au · 2026Article
- Chiral Analysis for High-Throughput Reaction Screening: Recent Advances in Accelerating Asymmetric Catalysis Discovery.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Molecular Recognition and Chirality Sensing with Metallocene Dichloride Complexes.The Journal of organic chemistry · 2026Article
- Integrating Catalysis and Analysis: Accelerated Asymmetric Reaction Development With a Multitasking Reactivity Umpolung/Chiroptical Reporter Auxiliary.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Molecular Sensing of Chiral Carboxylic Acid Enantiomers Using CD Inductions in the Visible Light Region.The Journal of organic chemistry · 2025Article
- Optical Enantiodifferentiation of Chiral Nitriles.Organic letters · 2024Article
- Chiral CoInorganic chemistry · 2023Article
- Chiroptical Enhancement of Chiral Dicarboxylic Acids from Confinement in a Stereodynamic Supramolecular Cage.ACS sensors · 2022Article
- Optical deciphering of multinary chiral compound mixtures through organic reaction based chemometric chirality sensing.Nature communications · 2021Article
- Fluorescence detected circular dichroism (FDCD) for supramolecular host-guest complexes.Chemical science · 2021Article
- High-throughput assay for determining enantiomeric excess of chiral diols, amino alcohols, and amines and for direct asymmetric reaction screening.Nature protocols · 2020Article
- Article
- Click chemistry enables quantitative chiroptical sensing of chiral compounds in protic media and complex mixtures.Nature communications · 2018Article
- Macroscopic helical chirality and self-motion of hierarchical self-assemblies induced by enantiomeric small molecules.Nature communications · 2018Article
- The In Situ Enzymatic Screening (ISES) Approach to Reaction Discovery and Catalyst Identification.Current protocols in chemical biology · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular recognition, activation and dynamic self-assembly with Brønsted and Lewis acids play a central role across the chemical sciences including catalysis, crystal engineering, supramolecular architectures and drug design. Despite this general advance, the utilization of the corresponding binding motifs for fast and robust quantitative chemosensing of chiral compounds in a complicate matrix has remained challenging. Here we show that a stereodynamic probe carrying complementary boronic acid and urea units achieves this goal with hydroxy carboxylic acids. Synergistic dual-site binding and instantaneous chirality imprinting result in characteristic ultraviolet and CD readouts that allow instantaneous determination of the absolute configuration, enantiomeric excess and concentration of the target compound even in complex mixtures. The robustness and practicality of this strategy for high-throughput screening purposes is demonstrated. Comprehensive sensing of only 0.5 mg of a crude reaction mixture of an asymmetric reduction eliminates cumbersome work-up protocols and minimizes analysis time, labour and waste production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.