Evidence map›Paper›PMID 27549912›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2016

Quenching of pH-Responsive Luminescence of a Benzoindolizine Sensor by an Ultrafast Hydrogen Shift.

Jiawang Zhou, Victor K Outlaw, Craig A Townsend, Arthur E Bragg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. A four-state fluorescent molecular switch.Chemical communications (Cambridge, England) · 2018
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiawang ZhouDepartment of Chemistry, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD, 21218, USA.
Victor K OutlawDepartment of Chemistry, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD, 21218, USA.
Craig A TownsendDepartment of Chemistry, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD, 21218, USA.
Arthur E BraggDepartment of Chemistry, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD, 21218, USA. artbragg@jhu.edu.ORCID http://orcid.org/0000-0002-3376-5494

Funding

Iterative Polyketide Synthase Function, Structure and PathwaysR01ES001670 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI TOWNSEND, CRAIG ARTHUR · 1985 to 2023
$9.2M
NIEHS NIH HHS R01 ES001670
6 · The paper itself

Abstract

Fluorescent-sensor design requires consideration of how photochemical dynamics control properties of a sensing state. Transient absorption (TA) spectroscopy reveals an ultrafast net [1,3]-hydrogen shift following excitation of a protonated methoxy benzoindolizine (bzi) sensor in solution. These photochemical dynamics explain a quenched pH-responsive fluorescence shift and dramatically reduced fluorescence quantum yield relative to other (e. g. methyl) bzi compounds that do not tautomerize. Calculations predict the energetic and structural feasibility for rearrangement in protonated bzi compounds, such that interaction between the pi-network and strongly electron-donating methoxyl must lower the barrier for suprafacial H or H

Indexed as

benzoindolizinefemtochemistryfluorescent probeshydrogen transfertime-resolved spectroscopy

Identifiers

PMID27549912
PMCPMC5113014

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.