Evidence map›Paper›PMID 27549771›Full record

ArticleCancer causes & control : CCC2016

Endometriosis and mammographic density measurements in the Nurses' Health Study II.

Leslie V Farland, Rulla M Tamimi, A Heather Eliassen, Donna Spiegelman, Kimberly A Bertrand, Stacey A Missmer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Leslie V FarlandDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA. lfarland@mail.harvard.edu.ORCID 0000-0001-7455-8531
Rulla M TamimiDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA.
A Heather EliassenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA.
Donna SpiegelmanDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA.
Kimberly A BertrandSlone Epidemiology Center, Boston University, Boston, MA, USA.
Stacey A MissmerDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA.
Brigham and Women's Hospital · USBoston University · US

Funding

Risk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3M
Life Course Cancer Epidemiology Cohort in WomenUM1CA176726 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2013 to 2017
$15.7M
Harvard Education Program in Cancer Prevention Control (R25T)R25CA057711 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI DAVISON, KIRSTEN · 1992 to 2018
$8.5M
Immunology, Inflammation, and EndometriosisR01HD057210 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI MISSMER, STACEY ANN · 2009 to 2012
$1.4M
Predoctoral Training Program in Reproductive, Perinatal & Pediatric EpidemiologyT32HD060454 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI MICHELS, KARIN B · 2010 to 2014
$1.1M
NCI NIH HHS R01 CA050385NCI NIH HHS R25 CA057711NCI NIH HHS UM1 CA176726NICHD NIH HHS R01 HD057210NICHD NIH HHS T32 HD060454
6 · The paper itself

Abstract

purposeEndometriosis and mammographic density have been hypothesized to be influenced by sex steroid hormonal exposures in adolescence and early adulthood. We investigated the association between endometriosis and mammographic density, a consistent and independent risk factor for breast cancer.

methodsWe conducted a cross-sectional analysis among 1,581 pre- and postmenopausal women not previously diagnosed with breast cancer in the Nurses' Health Study II cohort. We measured average percent mammographic density and absolute dense and non-dense breast area using a validated computer-assisted method. Multivariable linear regression was used to estimate the association between endometriosis and mammographic density among pre- and postmenopausal women separately.

resultsAmong premenopausal women, average percent mammographic density was 43.1 % among women with endometriosis (n = 91) and 40.5 % among women without endometriosis (n = 1,150). Endometriosis was not associated significantly with mammographic density among premenopausal (% difference = 2.00 percentage points 95 % CI -1.33, 5.33) or among postmenopausal women (% difference = -0.89 percentage points 95 % CI -5.10, 3.33). Among premenopausal women, there was heterogeneity by BMI at age 18 (p value = 0.003), with a suggested association among those who were lean at age 18 (BMI < 20.6 kg/m(2)) (% difference = 3.74 percentage points 95 % CI -0.29, 7.78).

conclusionEndometriosis was not found to be associated with overall measurements of mammographic density.

Indexed as

Breast DensityAdultBreast NeoplasmsCross-Sectional StudiesEndometriosisFemaleHumansMammographyMiddle AgedPostmenopausePremenopauseRisk FactorsUnited KingdomBreast cancerBreast densityEndometriosisEpidemiologyMammographic density

Identifiers

PMID27549771
PMCPMC5048469
OpenAlexW2511749531

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.