Evidence map›Paper›PMID 27549684›Full record

ReviewLancet (London, England)2017

Viral bronchiolitis.

Todd A Florin, Amy C Plint, Joseph J Zorc

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Lancet (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06267118 (A Randomized Controlled Trial on the Comparative Efficacy of Hypertonic Saline vs Adrenaline Nebulization in Acute Bronchiolitis in Children), which is not on this map. Cited by 205 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
205citing papers in PubMed, 10 pooled it
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06267118 phase3recruitingnot on this mapstarted 2023, after this paper: background citation

A Randomized Controlled Trial on the Comparative Efficacy of Hypertonic Saline vs Adrenaline Nebulization in Acute Bronchiolitis in Children

TypeinterventionalSponsorCombined Military Hospital, PakistanRan2023 to 2024Enrolled60ConditionsAcute Bronchiolitis Due to Respiratory Syncytial VirusArmsHypertonic Saline Solution, 1 Ml, Adrenaline
3 · Its place in the literature

Who cites it

205 citing papers in PubMed, 10 syntheses or guidelines pooled it, 435 citations in OpenAlex.

  1. Pooled it
  2. Air pollution and hospitalization risk in infants with bronchiolitis: A systematic review and meta-analysis.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
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145 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Todd A FlorinDivision of Pediatric Emergency Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: todd.florin@cchmc.org.
Amy C PlintDivision of Emergency Medicine, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada; Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada.
Joseph J ZorcDivision of Emergency Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Children's Hospital of Eastern Ontario · CAChildren's Hospital of Philadelphia · USUniversity of Cincinnati Medical Center · US

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
BIOMARKERS AND RISK STRATIFICATION IN PEDIATRIC COMMUNITY-ACQUIRED PNEUMONIAK23AI121325 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI FLORIN, TODD ADAM · 2016 to 2019
$743k
National Institutes of Health National Institute of Allergy and Infectious Diseases 1K23AI121325-01NCATS NIH HHS UL1 TR001425NIAID NIH HHS K23 AI121325
6 · The paper itself

Abstract

Viral bronchiolitis is a common clinical syndrome affecting infants and young children. Concern about its associated morbidity and cost has led to a large body of research that has been summarised in systematic reviews and integrated into clinical practice guidelines in several countries. The evidence and guideline recommendations consistently support a clinical diagnosis with the limited role for diagnostic testing for children presenting with the typical clinical syndrome of viral upper respiratory infection progressing to the lower respiratory tract. Management is largely supportive, focusing on maintaining oxygenation and hydration of the patient. Evidence suggests no benefit from bronchodilator or corticosteroid use in infants with a first episode of bronchiolitis. Evidence for other treatments such as hypertonic saline is evolving but not clearly defined yet. For infants with severe disease, the insufficient available data suggest a role for high-flow nasal cannula and continuous positive airway pressure use in a monitored setting to prevent respiratory failure.

Indexed as

PediatricsBronchiolitis, ViralBronchodilator AgentsContinuous Positive Airway PressureDisease ManagementHumansSaline Solution, HypertonicBronchodilator AgentsSaline Solution, Hypertonic

Identifiers

PMID27549684
PMCPMC6765220
OpenAlexW4206442590

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.