ArticleBiology direct2016
Should tissue structure suppress or amplify selection to minimize cancer risk?
Article in Biology direct, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Integration of Immune Cell-Target Cell Conjugate Dynamics Changes the Time Scale of Immune Control of Cancer.Bulletin of mathematical biology · 2025Article
- Evolutionary graph theory beyond single mutation dynamics: on how network-structured populations cross fitness landscapes.Genetics · 2024Article
- A theory of evolutionary dynamics on any complex population structure reveals stem cell niche architecture as a spatial suppressor of selection.Nature communications · 2024Article
- Spectral dynamics of guided edge removals and identifying transient amplifiers for death-Birth updating.Journal of mathematical biology · 2023Article
- Suppressors of fixation can increase average fitness beyond amplifiers of selection.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Trade-off between reducing mutational accumulation and increasing commitment to differentiation determines tissue organization.Nature communications · 2022Article
- Spectral analysis of transient amplifiers for death-birth updating constructed from regular graphs.Journal of mathematical biology · 2021Article
- Evolutionary bet-hedging in structured populations.Journal of mathematical biology · 2021Article
- Fixation probabilities in graph-structured populations under weak selection.PLoS computational biology · 2021Article
- Article
- Transient amplifiers of selection and reducers of fixation for death-Birth updating on graphs.PLoS computational biology · 2020Article
- Exploring and mapping the universe of evolutionary graphs identifies structural properties affecting fixation probability and time.Communications biology · 2019Article
- Evolutionary regime transitions in structured populations.PloS one · 2018Article
- The evolutionary trade-off between stem cell niche size, aging, and tumorigenesis.Evolutionary applications · 2017Article
- Takeover times for a simple model of network infection.Physical review. E · 2017Article
- A population genetics perspective on the determinants of intra-tumor heterogeneity.Biochimica et biophysica acta. Reviews on cancer · 2017Review
- Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations.Nature communications · 2017Article
- Suppressors of selection.PloS one · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has been frequently argued that tissues evolved to suppress the accumulation of growth enhancing cancer inducing mutations. A prominent example is the hierarchical structure of tissues with high cell turnover, where a small number of tissue specific stem cells produces a large number of specialized progeny during multiple differentiation steps. Another well known mechanism is the spatial organization of stem cell populations and it is thought that this organization suppresses fitness enhancing mutations. However, in small populations the suppression of advantageous mutations typically also implies an increased accumulation of deleterious mutations. Thus, it becomes an important question whether the suppression of potentially few advantageous mutations outweighs the combined effects of many deleterious mutations.
resultsWe argue that the distribution of mutant fitness effects, e.g. the probability to hit a strong driver compared to many deleterious mutations, is crucial for the optimal organization of a cancer suppressing tissue architecture and should be taken into account in arguments for the evolution of such tissues.
conclusionWe show that for systems that are composed of few cells reflecting the typical organization of a stem cell niche, amplification or suppression of selection can arise from subtle changes in the architecture. Moreover, we discuss special tissue structures that can suppress most types of non-neutral mutations simultaneously. REVIEWERS: This article was reviewed by Benjamin Allen, Andreas Deutsch and Ignacio Rodriguez-Brenes. For the full reviews, please go to the Reviewers' comments section.
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