ArticleWorld journal of surgery2017
Invasion Depth Measured in Millimeters is a Predictor of Survival in Patients with Distal Bile Duct Cancer: Decision Tree Approach.
Article in World journal of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 23 citations in OpenAlex.
- Concept of Depth of Invasion Can Improve Staging Performance in Patients with Resected Distal Cholangiocarcinoma: Validation of the American Joint Committee on Cancer Staging System.Cancer research and treatment · 2026Article
- Clinical impact of pancreatic invasion in T1-stage distal bile duct cancer and prognostic factors associated with long-term survival: A multicenter study.Journal of hepato-biliary-pancreatic sciences · 2024Article
- Subserosal Layer and/or Pancreatic Invasion Based on Anatomical Features as a Novel Prognostic Indicator in Patients with Distal Cholangiocarcinoma.Diagnostics (Basel, Switzerland) · 2023Article
- Retrospective analysis of 8th edition American Joint Cancer Classification: Distal cholangiocarcinoma.Annals of hepato-biliary-pancreatic surgery · 2023Article
- Prognostic Significance of Growth Pattern in Predicting Outcome ofFrontiers in public health · 2022Article
- Prognostic significance of tumor-infiltrating lymphocytes in predicting outcome of distal cholangiocarcinoma in Thailand.Frontiers in oncology · 2022Article
- A Comparative Classification Analysis of Abdominal Aortic Aneurysms by Machine Learning Algorithms.Annals of biomedical engineering · 2020Article
- Article
- Observational
- Prognostic profile of patients with non-viral hepatocellular carcinoma: A comparative study with hepatitis C virus-related hepatocellular carcinoma using data mining analysis.Oncology letters · 2019Article
- Dual-organ invasion is associated with a lower survival rate than single-organ invasion distal bile duct cancer: A multicenter study.Scientific reports · 2018Article
- Relationship between lymphovascular invasion and clinicopathological features of papillary thyroid carcinoma.Bosnian journal of basic medical sciences · 2017Article
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Authors and funding
19 authors at 5 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAJCC staging system is unreliable for predicting survival in distal bile duct (DBD) cancer patients, due to inter-observer variation. Measured depth of invasion (DOI) is suggested to be more accurate to predict patients' clinical outcome in extra-hepatic cholangiocarcinomas, but its significance in DBD cancer and cutoff values are still debatable. This study aimed to identify the optimal cutoff value of DOI in relation to prognosis in DBD cancer patients.
methodsData of 179 patients with DBD adenocarcinoma treated in three institutions were investigated. Under microscopic review, DOI was measured. The relationships between the clinicopathological parameters and the groups based on DOI (≤3; 3-10; >10 mm) were evaluated, and the survival times of each group based on DOI and T classification were compared.
resultsDeeply invading tumors exhibited a greater tendency toward the infiltrative type, high histological grade, AJCC stage, and pancreatic, duodenal, lymphovascular and perineural invasion. The measured DOI was significantly correlated with worse relapse-free and overall survival (all p < 0.05). In multivariate analyses, the DOI remained as one of the prognostic factors (all p < 0.05), while T classification was not a significant prognostic factor. The new prognostic models (low, intermediate, and high risk) that applied DOI and nodal metastasis showed significant difference in recurrence and survival rate (all p < 0.05).
conclusionsOn the basis of the proposed cutoff value, the DOI could be clear and meaningful, overcoming the vagueness of the T classification for predicting clinical outcomes in patients with DBD carcinoma.
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