ArticleNature communications2016
Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 47 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
13.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Meta-Analysis of COVID-19 Metabolomics Identifies Variations in Robustness of Biomarkers.International journal of molecular sciences · 2023Pooled it
- Pooled it
- Exploring promising biomarkers based on pathogenic mechanisms in interstitial cystitis/bladder pain syndrome.Nature reviews. Urology · 2026Review
- Pathogenic Drivers of Difficult-to-Treat Rheumatoid Arthritis: Synovium and Beyond.International journal of molecular sciences · 2026Review
- Frontiers in Rheumatoid Arthritis: Emerging Research and Unmet Needs in Pharmacologic Management.Pharmaceuticals (Basel, Switzerland) · 2026Review
- From Multimorbidity to Network Medicine in Patients with Rheumatic Diseases.Rheumatology and therapy · 2025Review
- Carriers of HLA-DRB1*04:05 have a better clinical response to abatacept in rheumatoid arthritis.Scientific reports · 2023Article
- Machine learning identifies a profile of inadequate responder to methotrexate in rheumatoid arthritis.Rheumatology (Oxford, England) · 2023Article
- Developing better digital health measures of Parkinson's disease using free living data and a crowdsourced data analysis challenge.PLOS digital health · 2023Article
- Does persistence to methotrexate treatment in early rheumatoid arthritis have a familial component?Arthritis research & therapy · 2022Article
- Machine learning predicts response to TNF inhibitors in rheumatoid arthritis: results on the ESPOIR and ABIRISK cohorts.RMD open · 2022Article
- Integrating multimodal data through interpretable heterogeneous ensembles.bioRxiv : the preprint server for biology · 2022Article
- Integrating multimodal data through interpretable heterogeneous ensembles.Bioinformatics advances · 2022Article
- Multi-omics approach to precision medicine for immune-mediated diseases.Inflammation and regeneration · 2021Review
- Red meat intake is associated with early onset of rheumatoid arthritis: a cross-sectional study.Scientific reports · 2021Article
- Statistical Hypothesis Testing versus Machine Learning Binary Classification: Distinctions and Guidelines.Patterns (New York, N.Y.) · 2020Review
- Lower peripheral helper T cell levels in the synovium are associated with a better response to anti-TNF therapy in rheumatoid arthritis.Arthritis research & therapy · 2020Article
- Data Heterogeneity: The Enzyme to Catalyze Translational Bioinformatics?Journal of medical Internet research · 2020Article
- Predicting the treatment response of certolizumab for individual adult patients with rheumatoid arthritis: protocol for an individual participant data meta-analysis.Systematic reviews · 2020Article
- Tumor neoantigenicity assessment with CSiN score incorporates clonality and immunogenicity to predict immunotherapy outcomes.Science immunology · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
94 authors at 20 institutions in 12 countries.
Solveig K SiebertsSage Bionetworks, Seattle, Washington 98115, USA.
Fan ZhuDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Javier García-GarcíaStructural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain.
Eli StahlCenter for Statistical Genetics, Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Abhishek PratapSage Bionetworks, Seattle, Washington 98115, USA.
Gaurav PandeyIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.ORCID http://orcid.org/0000-0003-1939-679X
Dimitrios PappasDivision of Rheumatology, Department of Medicine, Columbia University, New York, New York 10032, USA.
Daniel AguilarStructural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain.
Bernat AntonStructural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain.
Jaume BonetStructural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain.ORCID http://orcid.org/0000-0001-5210-4387
Ridvan EksiDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Oriol FornésStructural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain.
Emre GuneyCenter for Complex Network Research, Northeastern University, Boston, Massachusetts 02115, USA.
Hongdong LiDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Manuel Alejandro MarínStructural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain.
Bharat PanwarDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Joan Planas-IglesiasStructural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain.
Daniel PoglayenStructural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain.
Jing CuiDivision of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Andre O FalcaoDepartment of Informatics, Faculty of Sciences, University of Lisbon, Lisbon 1749-016, Portugal.
Christine SuverSage Bionetworks, Seattle, Washington 98115, USA.ORCID http://orcid.org/0000-0002-2986-385X
Bruce HoffSage Bionetworks, Seattle, Washington 98115, USA.ORCID http://orcid.org/0000-0002-4629-2091
Venkat S K BalagurusamyIBM T.J. Watson Research Center, Yorktown Heights, New York, New York 10598, USA.
Donna DillenbergerIBM T.J. Watson Research Center, Yorktown Heights, New York, New York 10598, USA.
Elias Chaibub NetoSage Bionetworks, Seattle, Washington 98115, USA.
Thea NormanSage Bionetworks, Seattle, Washington 98115, USA.
Tero AittokallioIBM T.J. Watson Research Center, Yorktown Heights, New York, New York 10598, USA.
Muhammad Ammad-Ud-DinDepartment of Computer Science, Aalto University, Espoo 02150, Finland.
Chloe-Agathe AzencottMINES ParisTech, PSL-Research University, CBIO-Centre for Computational Biology, Fontainebleau 77300, France.ORCID http://orcid.org/0000-0003-1003-301X
Víctor BellónMINES ParisTech, PSL-Research University, CBIO-Centre for Computational Biology, Fontainebleau 77300, France.
Valentina BoevaMINES ParisTech, PSL-Research University, CBIO-Centre for Computational Biology, Fontainebleau 77300, France.
Kerstin BunteDepartment of Computer Science, Aalto University, Espoo 02150, Finland.
Himanshu ChhedaInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014, Finland.
Lu ChengInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014, Finland.
Jukka CoranderHelsinki Institute for Information Technology (HIIT), Esbo 02150, Finland.
Michel DumontierStanford Center for Biomedical Informatics, Stanford University, Stanford, California 94305, USA.ORCID http://orcid.org/0000-0003-4727-9435
Anna GoldenbergDepartment of Computer Science, University of Toronto, Toronto, Ontario, Canada M5G OA5.
Peddinti GopalacharyuluInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014, Finland.ORCID http://orcid.org/0000-0002-8767-968X
Mohsen HajilooGenetics and Genome Biology, SickKids Research Institute, Toronto, Ontario, Canada M5G 0A4.
Daniel HidruDepartment of Computer Science, University of Toronto, Toronto, Ontario, Canada M5G OA5.
Alok JaiswalInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014, Finland.
Samuel KaskiDepartment of Computer Science, Aalto University, Espoo 02150, Finland.
Beyrem KhalfaouiGenetics and Genome Biology, SickKids Research Institute, Toronto, Ontario, Canada M5G 0A4.
Suleiman Ali KhanInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014, Finland.
Eric R KramerDepartment of Integrative Structural and Computational Biology, The Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, California 92037, USA.
Pekka MarttinenDepartment of Computer Science, Aalto University, Espoo 02150, Finland.
Aziz M MezliniDepartment of Computer Science, University of Toronto, Toronto, Ontario, Canada M5G OA5.
Bhuvan MolpariaDepartment of Integrative Structural and Computational Biology, The Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, California 92037, USA.
Matti PirinenInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014, Finland.
Janna SaarelaInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014, Finland.
Matthias SamwaldCenter for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna 1090, Austria.
Véronique StovenMINES ParisTech, PSL-Research University, CBIO-Centre for Computational Biology, Fontainebleau 77300, France.
Hao TangQuantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Jing TangInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014, Finland.
Ali TorkamaniDepartment of Integrative Structural and Computational Biology, The Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, California 92037, USA.
Jean-Phillipe VertMINES ParisTech, PSL-Research University, CBIO-Centre for Computational Biology, Fontainebleau 77300, France.
Bo WangQuantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Tao WangQuantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.ORCID http://orcid.org/0000-0002-4355-149X
Krister WennerbergInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014, Finland.
Nathan E WineingerDepartment of Integrative Structural and Computational Biology, The Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, California 92037, USA.
Guanghua XiaoQuantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Yang XieQuantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Rae YeungDepartment of Paediatrics, Department of Immunology, Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
Xiaowei ZhanQuantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Cheng ZhaoDepartment of Computer Science, University of Toronto, Toronto, Ontario, Canada M5G OA5.
Members of the Rheumatoid Arthritis Challenge Consortium
Jeff GreenbergSage Bionetworks, Seattle, Washington 98115, USA.
Joel KremerDepartment of Medicine, Division of Rheumatology, Albany Medical College, Albany, New York 12206, USA.
Kaleb MichaudDepartment of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.
Anne BartonArthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester M13 9PT, UK.ORCID http://orcid.org/0000-0003-3316-2527
Marieke CoenenDepartment of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen 6525 GA, The Netherlands.
Xavier MarietteDepartment of Rheumatology, Université Paris-Sud, Orsay 91400, France.
Corinne MiceliDepartment of Rheumatology, Université Paris-Sud, Orsay 91400, France.
Nancy ShadickDivision of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Michael WeinblattDivision of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Niek de VriesDepartment of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.
Paul P TakDepartment of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.
Danielle GerlagDepartment of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.
Tom W J HuizingaDepartment of Rheumatology, Leiden University Medical Centre, Leiden 2300 RC, The Netherlands.
Fina KurreemanDepartment of Rheumatology, Leiden University Medical Centre, Leiden 2300 RC, The Netherlands.
Cornelia F AllaartMerck Research Labs, Merck and Co., Inc., Boston, Massachusetts 02115, USA.
S Louis BridgesDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Lindsey CriswellRosalind Russell/Ephraim P Engleman Rheumatology Research Center, Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA.
Larry MorelandDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
Lars KlareskogRheumatology Unit, Department of Medicine, Karolinska Hospital and Karolinska Institutet, Solna 171 76 Stockholm, Sweden.
Saedis SaevarsdottirRheumatology Unit, Department of Medicine, Karolinska Hospital and Karolinska Institutet, Solna 171 76 Stockholm, Sweden.
Leonid PadyukovRheumatology Unit, Department of Medicine, Karolinska Hospital and Karolinska Institutet, Solna 171 76 Stockholm, Sweden.
Peter K GregersenRobert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York 11030, USA.
Stephen FriendSage Bionetworks, Seattle, Washington 98115, USA.
Robert PlengeMerck Research Labs, Merck and Co., Inc., Boston, Massachusetts 02115, USA.
Gustavo StolovitzkyIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Baldo OlivaStructural Bioinformatics Group (GRIB/IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain.
Yuanfang GuanDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Lara M MangraviteSage Bionetworks, Seattle, Washington 98115, USA.
University of Helsinki · FISage Bionetworks · USUniversitat Pompeu Fabra · ESInserm · FRThe University of Texas Southwestern Medical Center · USUniversity of Michigan · USUniversity of Toronto · CAIcahn School of Medicine at Mount Sinai · USKarolinska University Hospital · SEScripps Research Institute · USBrigham and Women's Hospital · USHelsinki Institute for Information Technology · FIIBM (United States) · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USUniversity of Pittsburgh · USGlaxoSmithKline (United Kingdom) · GBLeiden University Medical Center · NLNorthwell Health · USSickKids Foundation · CAUniversité Paris-Sud · FR
Funding
Longitudinal Comparative Effectiveness & Safety of Biologics in AutoimmunityR01HS018517 · AHRQ · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CURTIS, JEFFREY R. · 2009 to 2013
$2.2MImproving Polygenic Prediction using Next-Generation Data SetsR01GM105857 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SUNYAEV, SHAMIL · 2014 to 2017
$2.0MBoosting the Translational Impact of Scientific Competitions by Ensemble LearningR01GM114434 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PANDEY, GAURAV · 2015 to 2017
$1.3MEthnic Differences in the Risk of Fracture and Vascular DiseaseK23AR053351 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CURTIS, JEFFREY R. · 2007 to 2011
$755kAHRQ HHS R01 HS018517NIAMS NIH HHS K23 AR053351NIGMS NIH HHS R01 GM105857NIGMS NIH HHS R01 GM114434
Abstract
Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widely used to reduce disease progression, treatment fails in ∼one-third of patients. No biomarker currently exists that identifies non-responders before treatment. A rigorous community-based assessment of the utility of SNP data for predicting anti-TNF treatment efficacy in RA patients was performed in the context of a DREAM Challenge (http://www.synapse.org/RA_Challenge). An open challenge framework enabled the comparative evaluation of predictions developed by 73 research groups using the most comprehensive available data and covering a wide range of state-of-the-art modelling methodologies. Despite a significant genetic heritability estimate of treatment non-response trait (h(2)=0.18, P value=0.02), no significant genetic contribution to prediction accuracy is observed. Results formally confirm the expectations of the rheumatology community that SNP information does not significantly improve predictive performance relative to standard clinical traits, thereby justifying a refocusing of future efforts on collection of other data.
Indexed as
Polymorphism, Single NucleotideAdultAgedAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntirheumatic AgentsArthritis, RheumatoidCertolizumab PegolCohort StudiesCrowdsourcingFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedPrognosisAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntirheumatic AgentsCertolizumab PegolgolimumabTumor Necrosis Factor-alpha
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