Evidence map›Paper›PMID 27549318›Full record

ReviewCurrent HIV/AIDS reports2016

Frailty in HIV: Epidemiology, Biology, Measurement, Interventions, and Research Needs.

Damani A Piggott, Kristine M Erlandson, Kevin E Yarasheski

Open access · greenAbstract readReview
In one paragraph

Review in Current HIV/AIDS reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 100 citations in OpenAlex.

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  14. Geriatric syndromes in women living with HIV.Current opinion in HIV and AIDS · 2026
    Review
  15. Article
  16. Article
  17. Article
  18. Application of Pragmatic Criteria to Assessments of Frailty and Physical Function Among People With HIV.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  19. Article
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Damani A PiggottDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kristine M ErlandsonDepartment of Medicine, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA.
Kevin E YarasheskiDepartment of Medicine, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8127, St. Louis, MO, 63110, USA. kyarasheski@c2ndiagnostics.com.
Johns Hopkins Medicine · USUniversity of Colorado Anschutz Medical Campus · USWashington University in St. Louis · US

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 1995 to 2026
$32.6M
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Irfan J Lodhi · 2013 to 2026
$27.1M
TrainingP41GM103422 · NIGMS · WASHINGTON UNIVERSITY · PI YARASHESKI, KEVIN E · 2012 to 2019
$12.0M
The Impact of HIV and Aging on Physical Function and the Somatopause.K23AG050260 · NIA · UNIVERSITY OF COLORADO DENVER · PI ERLANDSON, KRISTINE MACE · 2014 to 2018
$946k
Determinants and Consequences of Frailty among Aging HIV-infected PersonsK23AI108357 · NIAID · JOHNS HOPKINS UNIVERSITY · PI PIGGOTT, DAMANI · 2013 to 2016
$731k
NIAID NIH HHS K23 AI108357NIA NIH HHS K23 AG050260NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK056341NIGMS NIH HHS P41 GM103422
6 · The paper itself

Abstract

Frailty is a critical aging-related syndrome marked by diminished physiologic reserve and heightened vulnerability to stressors, predisposing to major adverse clinical outcomes, including hospitalization, institutionalization, disability, and death in the general population of older adults. As the proportion of older adults living with HIV increases in the era of antiretroviral therapy, frailty is increasingly recognized to be of significant clinical and public health relevance to the HIV-infected population. This article reviews current knowledge on the epidemiology and biology of frailty and its potential role as a target for reducing disparities in outcomes in HIV; conceptual frameworks and current approaches to frailty measurement; existing data on frailty interventions; and important areas for future research focus necessary to develop and advance effective strategies to prevent or ameliorate frailty and its marked adverse consequences among people living with HIV.

Indexed as

AgingFrail ElderlyAgedHIV InfectionsHumansClinical outcomesDeficit accumulation indexDisparitiesImmunosenescencePhysical activityPhysical frailty phenotype

Identifiers

PMID27549318
PMCPMC5131367
OpenAlexW2517680219

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.