Trial reportBlood2016
Matching for the nonconventional MHC-I MICA gene significantly reduces the incidence of acute and chronic GVHD.
Open access · bronzeAbstract readClinical TrialMulticenter Study
In one paragraph
Trial report in Blood, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Review of Genetic Variation as a Predictive Biomarker for Chronic Graft-Versus-Host-Disease After Allogeneic Stem Cell Transplantation.Frontiers in immunology · 2020Pooled it
- Association between single nucleotide polymorphisms of tumor necrosis factor gene and grade II-IV acute GvHD: a systematic review and meta-analysis.Bone marrow transplantation · 2017Pooled it
- Advances inFrontiers in immunology · 2026Article
- The potential applications of peptide-loading complex in cancer treatment.Frontiers in immunology · 2025Review
- Soluble MHC class I chain-related protein A is a specific biomarker for the early detection of graft-versus-host disease.Frontiers in medicine · 2025Article
- Regulated cell death and DAMPs as biomarkers and therapeutic targets in normothermic perfusion of transplant organs. Part 1: their emergence from injuries to the donor organ.Frontiers in transplantation · 2025Review
- ASTCT Consensus Recommendations on Testing and Treatment of Patients with Donor-specific Anti-HLA Antibodies.Transplantation and cellular therapy · 2024Review
- Accurate multi-population imputation of MICA, MICB, HLA-E, HLA-F and HLA-G alleles from genome SNP data.PLoS computational biology · 2024Article
- Immunopathological mechanisms and clinical manifestations of ocular graft-versus-host disease following hematopoietic stem cell transplantation.Bone marrow transplantation · 2024Review
- Donor NKG2D rs1049174 polymorphism predicts hematopoietic recovery and event-free survival after single-unit cord blood transplantation in adults.Bone marrow transplantation · 2024Article
- Role of NKG2D ligands and receptor in haploidentical related donor hematopoietic cell transplantation.Blood advances · 2023Article
- High population frequencies ofFrontiers in immunology · 2023Article
- The impact of NKG2A and NKG2D receptors and HLA-E and MICA ligands polymorphisms on post-transplant complications after paediatric allogeneic HSCT: a single-centre experience.Frontiers in genetics · 2023Article
- Sequence Variations WithinFrontiers in immunology · 2022Article
- Single-Nucleotide Polymorphisms in MICA and MICB Genes Could Play a Role in the Outcome in AML Patients after HSCT.Journal of clinical medicine · 2021Article
- CAR-T Cell Therapy for Acute Myeloid Leukemia: Preclinical Rationale, Current Clinical Progress, and Barriers to Success.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2021Review
- Modern Medical Miracle: Matched Unrelated Donor Hematopoietic Stem Cell Transplant After Aplastic Anemia.Cureus · 2021Article
- Role of Polymorphisms of NKG2D Receptor and Its Ligands in Acute Myeloid Leukemia and Human Stem Cell Transplantation.Frontiers in immunology · 2021Review
- Article
- A diploid assembly-based benchmark for variants in the major histocompatibility complex.Nature communications · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
55 authors at 20 institutions in 7 countries.
Raphael CarapitoLaboratoire d'ImmunoRhumatologie Moléculaire, INSERM Unité Mixte de Recherche (UMR)_S1109, Plateforme GENOMAX, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg, and LabEx TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France; INSERM Franco-Japanese Nextgen HLA laboratory, Nagano, Japan and Strasbourg, France; Laboratoire d'Immunologie, Plateau Technique de Biologie, Pôle de Biologie, Nouvel Hôpital Civil, Strasbourg, France.
Nicolas JungLaboratoire d'ImmunoRhumatologie Moléculaire, INSERM Unité Mixte de Recherche (UMR)_S1109, Plateforme GENOMAX, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg, and LabEx TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France; INSERM Franco-Japanese Nextgen HLA laboratory, Nagano, Japan and Strasbourg, France.
Marius KwemouLaboratoire d'ImmunoRhumatologie Moléculaire, INSERM Unité Mixte de Recherche (UMR)_S1109, Plateforme GENOMAX, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg, and LabEx TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France; INSERM Franco-Japanese Nextgen HLA laboratory, Nagano, Japan and Strasbourg, France.
Meiggie UntrauLaboratoire d'ImmunoRhumatologie Moléculaire, INSERM Unité Mixte de Recherche (UMR)_S1109, Plateforme GENOMAX, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg, and LabEx TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France; INSERM Franco-Japanese Nextgen HLA laboratory, Nagano, Japan and Strasbourg, France.
Sandra MichelLaboratoire d'ImmunoRhumatologie Moléculaire, INSERM Unité Mixte de Recherche (UMR)_S1109, Plateforme GENOMAX, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg, and LabEx TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France; INSERM Franco-Japanese Nextgen HLA laboratory, Nagano, Japan and Strasbourg, France; Laboratoire d'Immunologie, Plateau Technique de Biologie, Pôle de Biologie, Nouvel Hôpital Civil, Strasbourg, France.
Angélique PichotLaboratoire d'ImmunoRhumatologie Moléculaire, INSERM Unité Mixte de Recherche (UMR)_S1109, Plateforme GENOMAX, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg, and LabEx TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France; INSERM Franco-Japanese Nextgen HLA laboratory, Nagano, Japan and Strasbourg, France.
Gaëlle GiacomettiLabEx TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France; BIOMICA SAS, Strasbourg, France.
Cécile MacquinLaboratoire d'ImmunoRhumatologie Moléculaire, INSERM Unité Mixte de Recherche (UMR)_S1109, Plateforme GENOMAX, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg, and LabEx TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France; INSERM Franco-Japanese Nextgen HLA laboratory, Nagano, Japan and Strasbourg, France.
Wassila IliasLaboratoire d'ImmunoRhumatologie Moléculaire, INSERM Unité Mixte de Recherche (UMR)_S1109, Plateforme GENOMAX, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg, and LabEx TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France; INSERM Franco-Japanese Nextgen HLA laboratory, Nagano, Japan and Strasbourg, France.
Aurore MorlonLabEx TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France; BIOMICA SAS, Strasbourg, France.
Irina KotovaLabEx TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France; BIOMICA SAS, Strasbourg, France.
Petya ApostolovaDepartment of Hematology and Oncology, Freiburg University Medical Center, Centre for Biological Signalling Studies BIOSS, Albert Ludwigs University, Freiburg, Germany.
Annette Schmitt-GraeffInstitute of Pathology, University Hospital, Freiburg, Germany.
Anne CesbronLabEx TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France; Etablissement Français du Sang (EFS) Pays de la Loire, Laboratoire HLA, Nantes, France; Société Francophone de Greffe de Moelle et de Thérapie Cellulaire, Hôpital Edouard Herriot, Centre Hospitalier Universitaire (CHU), Lyon, France; Société Francophone d'Histocompatibilité et d'Immunogénétique, Paris, France.
Katia GagneLabEx TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France; Etablissement Français du Sang (EFS) Pays de la Loire, Laboratoire HLA, Nantes, France; Laboratoire EA4271 "Immunovirologie et Polymorphisme Génétique," Nantes, France.
Machteld OudshoornEuropdonor, Matchis Foundation, Leiden, The Netherlands; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.
Bronno van der HoltHaemato Oncology Foundation for Adults in the Netherlands Data Center, Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Myriam LabaletteLaboratoire d'Immunologie, Centre Hospitalier Régional Universitaire de Lille, Lille, France; Lille Inflammation Research International Center INSERM U995, Université Lille 2, Lille, France.
Eric SpieringsLaboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
Christophe PicardAix-Marseille Université, Centre National de la Recherche Scientifique (CNRS), EFS, Anthropologie bio-culturelle, Droit, Éthique & Santé UMR 7268, Marseille, France.
Pascale LoiseauLabEx TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France; Société Francophone de Greffe de Moelle et de Thérapie Cellulaire, Hôpital Edouard Herriot, Centre Hospitalier Universitaire (CHU), Lyon, France; Laboratoire Jean Dausset, INSERM UMR_S 1160, Hôpital Saint-Louis, Paris, France.
Ryad TamouzaLabEx TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France; Laboratoire Jean Dausset, INSERM UMR_S 1160, Hôpital Saint-Louis, Paris, France.
Antoine ToubertLabEx TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France; Société Francophone de Greffe de Moelle et de Thérapie Cellulaire, Hôpital Edouard Herriot, Centre Hospitalier Universitaire (CHU), Lyon, France; Laboratoire Jean Dausset, INSERM UMR_S 1160, Hôpital Saint-Louis, Paris, France.
Anne ParissiadisSociété Francophone de Greffe de Moelle et de Thérapie Cellulaire, Hôpital Edouard Herriot, Centre Hospitalier Universitaire (CHU), Lyon, France; EFS Alsace Lorraine Champagne Ardenne, Laboratoire HLA, Strasbourg, France.
Valérie DuboisEFS Rhône-Alpes, Laboratoire HLA, Lyon, France.
Xavier LafargeEFS Aquitaine Limousin, Laboratoire HLA, Bordeaux, France.
Myriam Maumy-BertrandInstitut de Recherche Mathématique Avancée, CNRS UMR 7501, LabEx Institut de Recherche en Mathématiques, ses Interactions et Applications, Université de Strasbourg, Strasbourg, France.
Frédéric BertrandInstitut de Recherche Mathématique Avancée, CNRS UMR 7501, LabEx Institut de Recherche en Mathématiques, ses Interactions et Applications, Université de Strasbourg, Strasbourg, France.
Luca VagoHematology and Bone Marrow Transplantation Unit, and Unit of Immunogenetics, Leukemia Genomics, and Immunobiology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Fabio CiceriHematology and Bone Marrow Transplantation Unit, and.
Catherine PaillardLaboratoire d'ImmunoRhumatologie Moléculaire, INSERM Unité Mixte de Recherche (UMR)_S1109, Plateforme GENOMAX, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg, and LabEx TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France; Société Francophone de Greffe de Moelle et de Thérapie Cellulaire, Hôpital Edouard Herriot, Centre Hospitalier Universitaire (CHU), Lyon, France; Service d'Hématologie et d'Oncologie pédiatrique, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Sergi QuerolBarcelona Cord Blood Bank, Barcelona, Spain.
Jorge SierraHematology Department, Hospital de la Santa Creu I Sant Pau, IIB Sant Pau and Josep Carreras Leukemia Research Institute, Universitat Autònoma de Barcelona, Red de Càncer, Barcelona, Spain.
Katharina FleischhauerInstitute of Experimental Cellular Therapy, Essen University Hospital, Essen, Germany.
Arnon NaglerChaim Sheba Medical Center, Tel Aviv University, Tel-Hashomer, Israel.
Myriam LabopinDépartement d'Hématologie, Hôpital Saint Antoine, Paris, France.
Hidetoshi InokoINSERM Franco-Japanese Nextgen HLA laboratory, Nagano, Japan and Strasbourg, France; Department of Legal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
Peter A von dem BorneDepartment of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
Jürgen KuballDepartment of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands.
Masao OtaINSERM Franco-Japanese Nextgen HLA laboratory, Nagano, Japan and Strasbourg, France; Department of Legal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
Yoshihiko KatsuyamaINSERM Franco-Japanese Nextgen HLA laboratory, Nagano, Japan and Strasbourg, France; Department of Pharmacy, Shinshu University Hospital, Matsumoto, Japan.
Mauricette MichalletSociété Francophone de Greffe de Moelle et de Thérapie Cellulaire, Hôpital Edouard Herriot, Centre Hospitalier Universitaire (CHU), Lyon, France; Centre Hospitalier Lyon Sud, Hématologie 1G, Hospices Civils de Lyon, Pierre Bénite, Lyon, France.
Bruno LioureSociété Francophone de Greffe de Moelle et de Thérapie Cellulaire, Hôpital Edouard Herriot, Centre Hospitalier Universitaire (CHU), Lyon, France; Service d'Hématologie Adulte, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Régis Peffault de LatourLabEx TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France; Société Francophone de Greffe de Moelle et de Thérapie Cellulaire, Hôpital Edouard Herriot, Centre Hospitalier Universitaire (CHU), Lyon, France; Service d'Hématologie-Greffe, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.
Didier BlaiseSociété Francophone de Greffe de Moelle et de Thérapie Cellulaire, Hôpital Edouard Herriot, Centre Hospitalier Universitaire (CHU), Lyon, France; Institut Paoli Calmettes, Marseille, France.
Jan J CornelissenDepartment of Hematology and Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.
Ibrahim Yakoub-AghaSociété Francophone de Greffe de Moelle et de Thérapie Cellulaire, Hôpital Edouard Herriot, Centre Hospitalier Universitaire (CHU), Lyon, France; Lille Inflammation Research International Center INSERM U995, Université Lille 2, Lille, France.
Frans ClaasDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.
Philippe MoreauSociété Francophone de Greffe de Moelle et de Thérapie Cellulaire, Hôpital Edouard Herriot, Centre Hospitalier Universitaire (CHU), Lyon, France; Service d'Hématologie Clinique, CHU Hôtel Dieu, Nantes, France.
Noël MilpiedSociété Francophone de Greffe de Moelle et de Thérapie Cellulaire, Hôpital Edouard Herriot, Centre Hospitalier Universitaire (CHU), Lyon, France; Service d'Hématologie et de Thérapie Cellulaire, CHU Haut-Lévêque, Bordeaux, France.
Dominique CharronLabEx TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France; Laboratoire Jean Dausset, INSERM UMR_S 1160, Hôpital Saint-Louis, Paris, France.
Mohamad MohtySociété Francophone de Greffe de Moelle et de Thérapie Cellulaire, Hôpital Edouard Herriot, Centre Hospitalier Universitaire (CHU), Lyon, France; Département d'Hématologie, Hôpital Saint Antoine, Paris, France; Université Pierre & Marie Curie, Paris, France; and Centre de Recherche Saint-Antoine, INSERM UMR_S 938, Paris, France.
Robert ZeiserDepartment of Hematology and Oncology, Freiburg University Medical Center, Centre for Biological Signalling Studies BIOSS, Albert Ludwigs University, Freiburg, Germany.
Gérard SociéLabEx TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France; Société Francophone de Greffe de Moelle et de Thérapie Cellulaire, Hôpital Edouard Herriot, Centre Hospitalier Universitaire (CHU), Lyon, France; Service d'Hématologie-Greffe, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.
Seiamak BahramLaboratoire d'ImmunoRhumatologie Moléculaire, INSERM Unité Mixte de Recherche (UMR)_S1109, Plateforme GENOMAX, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg, and LabEx TRANSPLANTEX, Faculté de Médecine, Université de Strasbourg, Strasbourg, France; INSERM Franco-Japanese Nextgen HLA laboratory, Nagano, Japan and Strasbourg, France; Laboratoire d'Immunologie, Plateau Technique de Biologie, Pôle de Biologie, Nouvel Hôpital Civil, Strasbourg, France.
Université de Strasbourg · FRInserm · FRHôpital Edouard Herriot · FRFédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine · FRLeiden University Medical Center · NLCentre National de la Recherche Scientifique · FRUniversity Medical Center Utrecht · NLUniversity of Freiburg · DEAssistance Publique – Hôpitaux de Paris · FRErasmus MC · NLErasmus MC Cancer Institute · NLEssen University Hospital · DEÉtablissement Français du Sang · FRHôpital Cardiologique du Haut-Lévêque · FRHôpital Civil, Strasbourg · FRHôpital Saint-Louis · FRIstituti di Ricovero e Cura a Carattere Scientifico · ITLille Inflammation Research International Center · FRLimousin Regional Council · FRShinshu University · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Graft-versus-host disease (GVHD) is among the most challenging complications in unrelated donor hematopoietic cell transplantation (HCT). The highly polymorphic MHC class I chain-related gene A, MICA, encodes a stress-induced glycoprotein expressed primarily on epithelia. MICA interacts with the invariant activating receptor NKG2D, expressed by cytotoxic lymphocytes, and is located in the MHC, next to HLA-B Hence, MICA has the requisite attributes of a bona fide transplantation antigen. Using high-resolution sequence-based genotyping of MICA, we retrospectively analyzed the clinical effect of MICA mismatches in a multicenter cohort of 922 unrelated donor HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 10/10 allele-matched HCT pairs. Among the 922 pairs, 113 (12.3%) were mismatched in MICA MICA mismatches were significantly associated with an increased incidence of grade III-IV acute GVHD (hazard ratio [HR], 1.83; 95% confidence interval [CI], 1.50-2.23; P < .001), chronic GVHD (HR, 1.50; 95% CI, 1.45-1.55; P < .001), and nonelapse mortality (HR, 1.35; 95% CI, 1.24-1.46; P < .001). The increased risk for GVHD was mirrored by a lower risk for relapse (HR, 0.50; 95% CI, 0.43-0.59; P < .001), indicating a possible graft-versus-leukemia effect. In conclusion, when possible, selecting a MICA-matched donor significantly influences key clinical outcomes of HCT in which a marked reduction of GVHD is paramount. The tight linkage disequilibrium between MICA and HLA-B renders identifying a MICA-matched donor readily feasible in clinical practice.
Indexed as
Graft vs Host DiseaseHematopoietic Stem Cell TransplantationHistocompatibility TestingLinkage DisequilibriumAcute DiseaseAdolescentAdultAgedAllograftsChildChild, PreschoolChronic DiseaseFemaleHistocompatibility Antigens Class IHLA AntigensHumansHistocompatibility Antigens Class IHLA AntigensKLRK1 protein, humanMHC class I-related chain ANK Cell Lectin-Like Receptor Subfamily K
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