ArticleDrug delivery and translational research2017
Human barrier models for the in vitro assessment of drug delivery.
Article in Drug delivery and translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Barrier to Defend - Models of Pulmonary Barrier to Study Acute Inflammatory Diseases.Frontiers in immunology · 2022Pooled it
- An organotypic ectocervix mucosa model to study host-pathogen interaction of sexually transmitted infections.Materials today. Bio · 2026Article
- ReBiA-Robotic Enabled Biological Automation: 3D Epithelial Tissue Production.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Patient-Derived Lung Cancer "Sandwich Cultures" with a Preserved Tumor Microenvironment.Tissue engineering. Part C, Methods · 2024Article
- Optimization of Primary Human Bronchial Epithelial 3D Cell Culture with Donor-Matched Fibroblasts and Comparison of Two Different Culture Media.International journal of molecular sciences · 2023Article
- Human 3D Airway Tissue Models for Real-Time Microscopy: Visualizing Respiratory Virus Spreading.Cells · 2022Article
- Biological Models of the Lower Human Airways-Challenges and Special Requirements of Human 3D Barrier Models for Biomedical Research.Pharmaceutics · 2021Review
- Advanced human mucosal tissue models are needed to improve preclinical testing of vaccines.PLoS biology · 2021Article
- Susceptibility of Human Airway Tissue Models Derived From Different Anatomical Sites toFrontiers in cellular and infection microbiology · 2021Article
- Susceptibility of primary human airway epithelial cells toInnate immunity · 2021Article
- Investigation on Ciliary Functionality of Different Airway Epithelial Cell Lines in Three-Dimensional Cell Culture.Tissue engineering. Part A · 2020Article
- Activity of Tracheal Cytotoxin ofFrontiers in cellular and infection microbiology · 2020Article
- An intestinal model with a finger-like villus structure fabricated using a bioprinting process and collagen/SIS-based cell-laden bioink.Theranostics · 2020Article
- Influence of nasal polyp tissue on the differentiation and activation of T lymphocytes in a co-culture system.Biomedical reports · 2019Article
- Biomimetic Human Tissue Model for Long-Term Study ofFrontiers in microbiology · 2019Article
- An automated and parallelised DIY-dosing unit for individual and complex feeding profiles: Construction, validation and applications.PloS one · 2019Article
- 3D organ models-Revolution in pharmacological research?Pharmacological research · 2019Review
- A fast screening model for drug permeability assessment based on native small intestinal extracellular matrix.RSC advances · 2018Article
- Effects of the novel polyphenol conjugate DPP-23 on head and neck squamous cell carcinoma cellsOncology letters · 2018Article
- Mimicking Tumors: Toward More Predictive In Vitro Models for Peptide- and Protein-Conjugated Drugs.Bioconjugate chemistry · 2017Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vitro test systems gain increasing importance in preclinical studies to increase the predictivity and reduce animal testing. Of special interest herein are barrier tissues that guard into the human body. These barriers are formed by highly specialized tissues such as the skin, the airways, and the intestine. However, to recapitulate these tissues, researchers are currently restricted by a lack of suitable supporting scaffolds. In this study, we present biological scaffolds based on decellularized porcine gut segments that offer a natural environment for cell growth and differentiation. Employing these scaffolds, human barrier models of the skin, the airways, and the intestine that mimic the natural histological architecture of the respective tissue are generated. These models show tissue specific barrier properties, such as the stratification of the skin, the mucociliary phenotype of the airways, and polarization of the intestinal epithelium. To investigate the transport characteristics of the intestinal test system, we incubated the tissue models with fluorescein (P
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.