Evidence map›Paper›PMID 27549029›Full record

ArticleJournal of the American Geriatrics Society2016

Racial and Ethnic Differences in Initiation and Discontinuation of Antidementia Drugs by Medicare Beneficiaries.

Carolyn T Thorpe, Nicole R Fowler, Katherine Harrigan, Xinhua Zhao, Yihuang Kang, Joseph T Hanlon, Walid F Gellad, Loren J Schleiden, Joshua M Thorpe

Abstract readComparative Study
In one paragraph

Article in Journal of the American Geriatrics Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Pharmacoequity measurement framework: A tool to reduce health disparities.Journal of managed care & specialty pharmacy · 2025
    Article
  5. Article
  6. Article
  7. Mapping racial and ethnic healthcare disparities for persons living with dementia: A scoping review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Alzheimer's disease medication use and adherence patterns by race and ethnicity.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
  12. Article
  13. Article
  14. Racial/ethnic disparities in initiation and persistent use of anti-dementia medications.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022
    Article
  15. An HIT-Supported Care Coordination Framework for Reducing Structural Racism and Discrimination for Patients With ADRD.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022
    Review
  16. Article
  17. Article
  18. Review
  19. Aducanumab: Appropriate Use Recommendations.The journal of prevention of Alzheimer's disease · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carolyn T ThorpeDepartment of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania. ctthorpe@pitt.edu.
Nicole R FowlerSchool of Medicine and Center for Aging Research, Indiana University, Indianapolis, Indiana.
Katherine HarriganDepartment of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania.
Xinhua ZhaoDepartment of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania.
Yihuang KangDivision of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Joseph T HanlonDepartment of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania.
Walid F GelladCenter for Health Equity Research and Promotion, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania.
Loren J SchleidenDepartment of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania.
Joshua M ThorpeDepartment of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania.

Funding

VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6M
NIA NIH HHS P30 AG024827
6 · The paper itself

Abstract

objectivesTo examine racial and ethnic differences in initiation and time to discontinuation of antidementia medication in Medicare beneficiaries.

designRetrospective cohort study.

settingSecondary analysis of 2009-10 enrollment, claims, and Part D prescription data for a 10% national sample of U.S. Medicare fee-for-service beneficiaries.

participantsBeneficiaries aged 65 and older with Alzheimer's disease or related dementia (ADRD) before 2009 and no fills for antidementia medications in the first half of 2009 (N = 84,043). MEASUREMENTS: Initiation was defined as having one or more fills for antidementia medication in the second half of 2009 and discontinuation as a gap in coverage of 30 days or more during the year after initiation. The Andersen Behavioral Model was used to guide covariate selection.

resultsOverall, 3,481 (4.1%) of previous nonusers initiated antidementia medication in the second half of 2009. Of those initiating one drug class (acetylcholinesterase inhibitors (AChEIs) or memantine), 9% later added the other class, and 2% switched classes. Of initiators, 23% discontinued within 1 month, and 62% discontinued within 1 year. Hispanic beneficiaries were more likely than white beneficiaries to initiate (adjusted odds ratio = 1.25, 95% confidence interval (CI) = 1.10-1.41). Black and white beneficiaries did not differ in likelihood of initiation. Hispanic (adjusted hazard ratio (aHR) = 1.56, 95% CI = 1.34-1.82) and black (aHR = 1.25, 95% CI = 1.08-1.44) beneficiaries discontinued at a faster rate than white beneficiaries.

conclusionInitiation of antidementia medications was no different in black and white beneficiaries and more likely in Hispanic beneficiaries; black and Hispanic beneficiaries discontinued at a faster rate. More research into reasons explaining these differences is needed.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseBlack or African AmericanBlack PeopleCholinesterase InhibitorsCross-Cultural ComparisonDrug MonitoringDrug SubstitutionDrug Therapy, CombinationFemaleHispanic or LatinoHumansMaleMedicareMedication AdherenceCholinesterase InhibitorsMemantineNootropic Agentsantidementia medicationsdementiahealth disparitiesMedicaremedication discontinuation

Identifiers

PMID27549029
PMCPMC5026892

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.