ArticleNature cell biology2016
Sex hormones establish a reserve pool of adult muscle stem cells.
Article in Nature cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed.
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- Diversity challenges and reconciles genetics in facioscapulohumeral muscular dystrophy.Journal of human genetics · 2025Review
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- Mll4 in skeletal muscle fibers maintains muscle stem cells.Skeletal muscle · 2024Article
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- Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of murine juvenile myogenic progenitors.Nature communications · 2024Article
- Regenerating human skeletal muscle forms an emerging niche in vivo to support PAX7 cells.Nature cell biology · 2023Article
- Baf155 regulates skeletal muscle metabolism via HIF-1a signaling.PLoS biology · 2023Article
- Review
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- Human Tissue-Engineered Skeletal Muscle: A Tool for Metabolic Research.Endocrinology and metabolism (Seoul, Korea) · 2022Article
- Bap1/SMN axis in Dpp4+ skeletal muscle mesenchymal cells regulates the neuromuscular system.JCI insight · 2022Article
- Insights into muscle stem cell dynamics during postnatal development.The FEBS journal · 2022Review
- The Notch signaling network in muscle stem cells during development, homeostasis, and disease.Skeletal muscle · 2022Review
- Numb is required for optimal contraction of skeletal muscle.Journal of cachexia, sarcopenia and muscle · 2022Article
- Paternally expressed gene 3 (Pw1/Peg3) promotes sexual dimorphism in metabolism and behavior.PLoS genetics · 2022Article
- Current Thoughts of Notch's Role in Myoblast Regulation and Muscle-Associated Disease.International journal of environmental research and public health · 2021Review
- Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells.Nature communications · 2021Article
- Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis.Nature communications · 2021Article
- The hypothalamic-pituitary-gonadal axis controls muscle stem cell senescence through autophagosome clearance.Journal of cachexia, sarcopenia and muscle · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quiescent satellite cells, known as adult muscle stem cells, possess a remarkable ability to regenerate skeletal muscle following injury throughout life. Although they mainly originate from multipotent stem/progenitor cells of the somite, the mechanism underlying the establishment of quiescent satellite cell populations is unknown. Here, we show that sex hormones induce Mind bomb 1 (Mib1) expression in myofibres at puberty, which activates Notch signalling in cycling juvenile satellite cells and causes them to be converted into adult quiescent satellite cells. Myofibres lacking Mib1 fail to send Notch signals to juvenile satellite cells, leading to impaired cell cycle exit and depletion. Our findings reveal that the hypothalamic-pituitary-gonadal axis drives Mib1 expression in the myofibre niche. Moreover, the same axis regulates the re-establishment of quiescent satellite cell populations following injury. Our data show that sex hormones establish adult quiescent satellite cell populations by regulating the myofibre niche at puberty and re-establish them during regeneration.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.