ArticleNutrition & diabetes2016
Association between impaired fasting glycaemia in pediatric obesity and type 2 diabetes in young adulthood.
Article in Nutrition & diabetes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- A novel interactive mobile health support system for pediatric obesity treatment: a randomized controlled feasibility trial.BMC pediatrics · 2020Trial
- Impact of weight loss on cardiovascular function in adolescents and young adults with overweight/ obesity and intellectual and developmental disabilities.Disability and health journal · 2026Article
- Long-Term Cardiometabolic Outcomes in Children With Metabolically Healthy and Unhealthy Obesity.JAMA pediatrics · 2026Article
- Steatotic Liver Disease in Pediatric Obesity and Increased Risk for Youth-Onset Type 2 Diabetes.Diabetes care · 2024Article
- 'Prediabetes' as a practical distinctive window for workable fruitful wonders: Prevention and progression alert as advanced professionalism.World journal of clinical pediatrics · 2024Article
- Childhood sleep: physical, cognitive, and behavioral consequences and implications.World journal of pediatrics : WJP · 2024Review
- The Prevalence and Associated Factors of Impaired Fasting Glucose among Children and Adolescents in Urban China: A Large-Scale Cross-Sectional Study.Pediatric diabetes · 2024Article
- Association between Dietary Behavior and Overweight and Obesity among Chinese Students: A Cross-Sectional Study.Children (Basel, Switzerland) · 2023Article
- Article
- Triglyceride glucose index, pediatric NAFLD fibrosis index, and triglyceride-to-high-density lipoprotein cholesterol ratio are the most predictive markers of the metabolically unhealthy phenotype in overweight/obese adolescent boys.Frontiers in endocrinology · 2023Article
- Elevated fasting glucose level increases the risk of fatty liver disease: a 10-year study of 31,154 individuals.BMC gastroenterology · 2022Article
- Pediatric obesity-Long-term consequences and effect of weight loss.Journal of internal medicine · 2022Review
- Usability and Engagement Testing of mHealth Apps in Paediatric Obesity: A Narrative Review of Current Literature.International journal of environmental research and public health · 2022Review
- The Determinants of Adolescent Glycolipid Metabolism Disorder: A Cohort Study.International journal of endocrinology · 2022Article
- Prevalence of increased transaminases and its association with sex, age, and metabolic parameters in children and adolescents with obesity - a nationwide cross-sectional cohort study.BMC pediatrics · 2021Article
- Perceptions of Family-Level Social Factors That Influence Health Behaviors in Latinx Adolescents and Young Adults at High Risk for Type 2 Diabetes.Children (Basel, Switzerland) · 2021Article
- The impacts of exercise on pediatric obesity.Clinical and experimental pediatrics · 2021Article
- Obesity in childhood, socioeconomic status, and completion of 12 or more school years: a prospective cohort study.BMJ open · 2021Article
- Association of childhood obesity with risk of early all-cause and cause-specific mortality: A Swedish prospective cohort study.PLoS medicine · 2020Article
- Metabolic Syndrome and Prediabetes Among Yemeni School-Aged Children.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIn adults, impaired fasting glycemia (IFG) increases the risk for type 2 diabetes mellitus (T2DM). This study aimed to investigate to which extent children with obesity develop T2DM during early adulthood, and to determine whether IFG and elevated hemoglobin A1c (HbA1c) in obese children are risk markers for early development of T2DM.
methodsIn this prospective cohort study, 1620 subjects from the Swedish Childhood Obesity Treatment Registry - BORIS who were ⩾18 years at follow-up and 8046 individuals in a population-based comparison group, matched on gender age and living area, were included. IFG was defined according to both ADA (cut-off 5.6 mmol l(-1)) and WHO (6.1 mmol l(-1)). Elevated HbA1c was defined according to ADA (cut-off 39 mmol l(-1)). Main outcome was T2DM medication, as a proxy for T2DM. Data on medications were retrieved from a national registry.
resultsThe childhood obesity cohort were 24 times more likely to receive T2DM medications in early adulthood compared with the comparison group (95% confidence interval (CI): 12.52-46). WHO-defined IFG predicted future use of T2DM medication with an adjusted hazard ratio (HR) of 3.73 (95% CI: 1.87-7.45) compared with those who had fasting glucose levels <5.6 mmol l(-1). A fasting glucose level of 5.6-6.0 mmol l(-1), that is, the IFG-interval added by American Diabetes Association (ADA), did not increase the use of T2DM medication more than pediatric obesity itself, adjusted HR=1.72 (0.84-3.52). Elevated levels of HbA1c resulted in an adjusted HR=3.12 (1.50-6.52). More severe degree of obesity also increased the future T2DM risk.
conclusionIFG according to WHO and elevated HbA1c (39-48 mmol l(-1)), but not the additional fasting glucose interval added by ADA (5.6-6.0 mmol l(-1)), can be considered as prediabetes in the obese pediatric population in Sweden.
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