ArticleMovement disorders : official journal of the Movement Disorder Society2016
Predictors of functional dependency in Parkinson's disease.
Article in Movement disorders : official journal of the Movement Disorder Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed.
- The Relationship between Care Dependency and Spiritual Care Needs of Parkinson's Patients in Turkey.Journal of religion and health · 2026Article
- Longitudinal patterns of loss of independence in Parkinson disease.Neurodegenerative disease management · 2026Article
- Subitem-level multi-scale assessment and machine learning for three-class cognitive status classification in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Reliability and validity of the Greek adaptation of the Modified Barthel Index in neurorehabilitation patients.European journal of physical and rehabilitation medicine · 2024Observational
- Using the cell phone while standing or walking affects balance and mobility in people with Parkinson's disease.Arquivos de neuro-psiquiatria · 2023Article
- Nomogram to Predict the Probability of Functional Dependence in Early Parkinson's Disease.Journal of Parkinson's disease · 2023Article
- Effects of Gyroscope on Arm Swing and Gait in Healthy Volunteers.Applied bionics and biomechanics · 2023Article
- Effects of Multimodal Rehabilitation on the Activities of Daily Living, Quality of Life, and Burden of Care for Patients with Parkinson's Disease: A Randomized Control Study.Healthcare (Basel, Switzerland) · 2022Article
- Association of serum cholesterol with Parkinson's disease in a cohort of statin-free individuals.Brain and behavior · 2022Article
- Predictors of Loss of Functional Independence in Parkinson's Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up and Comparison with a Control Group.Diagnostics (Basel, Switzerland) · 2021Article
- Contribution of neuropsychiatric symptoms in Parkinson's disease to different domains of caregiver burden.Journal of neurology · 2021Article
- The impact of freezing of gait on functional dependency in Parkinson's disease with regard to motor phenotype.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Longitudinal association between housing accessibility and activities of daily living: the role of self-efficacy and control in people ageing with Parkinson's disease.BMC geriatrics · 2020Article
- Non-pharmacological Treatment Challenges in Early Parkinson's Disease for Axial and Cognitive Symptoms: A Mini Review.Frontiers in neurology · 2020Review
- 5-2-1 Criteria: A Simple Screening Tool for Identifying Advanced PD Patients Who Need an Optimization of Parkinson's Treatment.Parkinson's disease · 2020Article
- Complex therapies for advanced Parkinson's disease: what is the role of doctor-patient communication?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Cognitive Performance in Parkinson's Disease in the Brain Health Registry.Journal of Alzheimer's disease : JAD · 2019Article
- Non-Motor Symptoms of Parkinson's Disease and Their Impact on Quality of Life in a Cohort of Moroccan Patients.Frontiers in neurology · 2018Article
- Development and validation of prognostic survival models in newly diagnosed Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society · 2018Article
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Abstract
backgroundFunctional dependency, the need for help in basic activities of daily living, is an important patient-oriented outcome. We aimed to describe the development of dependency in Parkinson's disease (PD) and identify independent prognostic factors for this outcome.
methodsWe analyzed data from the Parkinsonism Incidence in North-East Scotland (PINE) study, a prospective, community-based incident cohort of PD with ongoing follow-up. We described the development of dependency defined by a Schwab & England score of < 80% and a Barthel Index of <19. We identified the baseline predictors of dependency using multivariable Cox regression.
resultsIn 198 patients with PD, the rate of development of dependency was 14 per 100 person years. Older age at diagnosis (hazard ratio for 10-year increase 2.23 [95% confidence interval 1.66-2.98]), greater smoking history (hazard ratio for 10-pack-year increase, 1.15 [1.04-1.26]), more severe axial impairment (hazard ratio for 5-point increase in sum of axial items from UPDRS scale, 1.78 [1.30-2.44]), and lower MMSE score (hazard ratio 0.88 [0.79-0.98]) were independently associated with a higher risk of dependency as defined by Schwab & England. Only older age (hazard ratio for 10-year increase 1.35 [1.04-1.76]) and severity of axial impairment (hazard ratio for 5-point increase 1.85 [1.31-2.62]) were associated with a higher risk of dependency as defined by the Barthel Index. Sex, deprivation, comorbidity, overall UPDRS motor score, and disease stage were not independently associated with dependency.
conclusionThis is the first community-based study of dependency in PD. There was a high rate of dependency development. Older age, more smoking, more axial impairment, and poorer cognition were independent predictors. © 2016 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
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