Evidence map›Paper›PMID 27548631›Full record

ArticleNucleic acid therapeutics2016

The Polarization of M2b Monocytes in Cultures of Burn Patient Peripheral CD14

Ichiaki Ito, Kamlesh K Bhopale, Tomoki Nishiguchi, Jong O Lee, David N Herndon, Sumihiro Suzuki, Lawrence C Sowers, Fujio Suzuki, Makiko Kobayashi

Open access · greenAbstract read
In one paragraph

Article in Nucleic acid therapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Tumor-Associated Macrophage Subsets: Shaping Polarization and Targeting.International journal of molecular sciences · 2023
    Review
  3. Article
  4. Review
  5. Review
  6. M2b macrophage polarization and its roles in diseases.Journal of leukocyte biology · 2019
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ichiaki Ito1 Department of Internal Medicine, The University of Texas Medical Branch , Galveston, Texas.
Kamlesh K Bhopale1 Department of Internal Medicine, The University of Texas Medical Branch , Galveston, Texas.
Tomoki Nishiguchi1 Department of Internal Medicine, The University of Texas Medical Branch , Galveston, Texas.
Jong O Lee2 Shriners Hospitals for Children , Galveston, Texas.
David N Herndon2 Shriners Hospitals for Children , Galveston, Texas.
Sumihiro Suzuki3 University of North Texas Health Science Center , Fort Worth, Texas.
Lawrence C Sowers4 Department of Pharmacology and Toxicology, The University of Texas Medical Branch , Galveston, Texas.
Fujio Suzuki1 Department of Internal Medicine, The University of Texas Medical Branch , Galveston, Texas.
Makiko Kobayashi1 Department of Internal Medicine, The University of Texas Medical Branch , Galveston, Texas.
Shriners Hospitals for Children - Galveston · USThe University of Texas Medical Branch at Galveston · USUniversity of North Texas · US

Funding

Project 9: The role of androgen/corticosteroid in fat, muscle and glucose metabolism of burn victimsP50GM060338 · NIGMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI SZABO, CSABA · 2000 to 2017
$24.2M
CCL1 gene therapy to inhibit bacterial translocation in acute radiation syndromesU01AI107355 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SUZUKI, FUJIO · 2013 to 2017
$2.6M
NIAID NIH HHS U01 AI107355NIGMS NIH HHS P50 GM060338
6 · The paper itself

Abstract

M2b macrophages (Mφ) play a major role in the increased susceptibility of subacutely burned patients, to sepsis stemming from enterococcal translocation. Certain opportunistic infections in severely burned mice have been controlled by murine CCL1 antisense oligodeoxynucleotide (ODN), a specific polarizer of mouse M2bMφ. In the present study, we have screened CCL1 antisense ODN, which is active against human M2bMφ. Among the 20 CCL1 antisense ODNs synthesized in our laboratory, HCA-11 was shown to be the most active polarizer for human CCL1

Indexed as

AdolescentAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticBinding SitesBurnsCD163 AntigenCell DifferentiationChemokine CCL1ChildGene ExpressionHumansLeukocytesLipopolysaccharide ReceptorsMacrophagesMaleAntigens, CDAntigens, Differentiation, MyelomonocyticCCL1 protein, humanCcl1 protein, mouseCD163 AntigenChemokine CCL1Lipopolysaccharide ReceptorsOligodeoxyribonucleotidesOligonucleotides, AntisenseReceptors, Cell SurfaceRNA, Messenger

Identifiers

PMID27548631
PMCPMC5067856
OpenAlexW2512226071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.