ArticlePloS one2016
Rhodopsin and Melanopsin Contributions to the Early Redilation Phase of the Post-Illumination Pupil Response (PIPR).
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Assessing migraine patients with multifocal pupillographic objective perimetry.BMC neurology · 2021Trial
- Simulated and natural changes in intraocular transparency selectively affect photoreceptor-specific pupil responses.Scientific reports · 2026Article
- Recovery in pupillometric non-visual functions following chiasmal decompression in pituitary adenoma.Brain communications · 2026Article
- Differences in the pupillary responses to evening light between children and adolescents.Journal of physiological anthropology · 2024Article
- Do sleep and circadian characteristics predict alcohol use in adult drinkers?Alcohol, clinical & experimental research · 2024Article
- Non-image-forming vision as measured through ipRGC-mediated pupil constriction is not modulated by covert visual attention.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Differences in the Pupillary Responses to Evening Light between Children and Adolescents.bioRxiv : the preprint server for biology · 2023Article
- Handheld chromatic pupillometry can accurately and rapidly reveal functional loss in glaucoma.The British journal of ophthalmology · 2023Article
- Blue-light stimulation of the blind-spot constricts the pupil and enhances contrast sensitivity.PloS one · 2023Article
- Chromatic pupillometry for evaluating melanopsin retinal ganglion cell function in Alzheimer's disease and other neurodegenerative disorders: a review.Frontiers in psychology · 2023Review
- Synaptic inputs to displaced intrinsically-photosensitive ganglion cells in macaque retina.Scientific reports · 2022Article
- Melanopsin photoreception differentially modulates rod-mediated and cone-mediated human temporal vision.iScience · 2022Article
- Sleep and circadian differences between light and heavy adult alcohol drinkers.Alcoholism, clinical and experimental research · 2022Article
- Intrinsically photosensitive retinal ganglion cell-driven pupil responses in patients with traumatic brain injury.Vision research · 2021Article
- Supplemental light exposure improves sleep architecture in people with type 2 diabetes.Acta diabetologica · 2021Article
- Quantification of the early pupillary dilation kinetic to assess rod and cone activity.Scientific reports · 2021Article
- Detection of Parkinson's Disease Through Automated Pupil Tracking of the Post-illumination Pupillary Response.Frontiers in medicine · 2021Article
- Crosstalk: The diversity of melanopsin ganglion cell types has begun to challenge the canonical divide between image-forming and non-image-forming vision.The Journal of comparative neurology · 2020Review
- Effects of Mydriatics on Rod/Cone- and Melanopsin-driven Pupil Responses.Optometry and vision science : official publication of the American Academy of Optometry · 2020Article
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melanopsin expressing intrinsically photosensitive Retinal Ganglion Cells (ipRGCs) entirely control the post-illumination pupil response (PIPR) from 6 s post-stimulus to the plateau during redilation after light offset. However, the photoreceptor contributions to the early redilation phase of the PIPR (< 6 s post-stimulus) have not been reported. Here, we evaluated the photoreceptor contributions to the early phase PIPR (0.6 s to 5.0 s) by measuring the spectral sensitivity of the criterion PIPR amplitude in response to 1 s light pulses at five narrowband stimulus wavelengths (409, 464, 508, 531 and 592 nm). The retinal irradiance producing a criterion PIPR was normalised to the peak and fitted by either a single photopigment nomogram or the combined melanopsin and rhodopsin spectral nomograms with the +L+M cone photopic luminous efficiency (Vλ) function. We show that the PIPR spectral sensitivity at times ≥ 1.7 s after light offset is best described by the melanopsin nomogram. At times < 1.7 s, the peak PIPR sensitivity shifts to longer wavelengths (range: 482 to 498 nm) and is best described by the combined photoreceptor nomogram, with major contributions from melanopsin and rhodopsin. This first report of melanopsin and rhodopsin contributions to the early phase PIPR is in line with the electrophysiological findings of ipRGC and rod signalling after the cessation of light stimuli and provides a cut-off time for isolating photoreceptor specific function in healthy and diseased eyes.
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