ArticleNature nanotechnology2016
Quantum dot-loaded monofunctionalized DNA icosahedra for single-particle tracking of endocytic pathways.
Article in Nature nanotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- From Blueprint to Breakthrough: How Far Can We Fold DNA Origami for Nano-Enabled Technologies?JACS Au · 2026Review
- DNA cross-over motifs-based, programmable supramolecular hydrogels for the mechanoregulatory effects of cellular behaviour and cytoskeleton reorganization.npj biomedical innovations · 2026Article
- Microenvironment-confined kinetic elucidation and implementation of a DNA nano-phage with a shielded internal computing layer.Nature communications · 2025Article
- Dynamic Monitoring of Time-Dependent Evolution of Biomolecules Using Quantum Dots-Based Biosensors Assemblies.Biosensors · 2024Article
- DNA-based nanostructures for RNA delivery.Medical review (2021) · 2024Review
- Nanoscale 3D spatial addressing and valence control of quantum dots using wireframe DNA origami.Nature communications · 2022Article
- Reconfiguration of DNA nanostructures induced by enzymatic ligation treatment.Nucleic acids research · 2022Article
- Valence-controlled protein conjugation on nanoparticlesChemical science · 2022Article
- Article
- A DNA nanodevice boosts tumour immunity.Nature nanotechnology · 2021Article
- Membrane-Interacting DNA Nanotubes Induce Cancer Cell Death.Nanomaterials (Basel, Switzerland) · 2021Article
- Article
- Chiral Systems Made from DNA.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Nanoscopy for endosomal escape quantification.Nanoscale advances · 2021Review
- Nucleic Acids Analysis.Science China. Chemistry · 2021Review
- DNA Nanodevices to Probe and Program Membrane Organization, Dynamics, and Applications.The Journal of membrane biology · 2020Review
- Quantitative Imaging of BiochemistryACS central science · 2020Review
- Quantum Dot-Conjugated SARS-CoV-2 Spike Pseudo-Virions Enable Tracking of Angiotensin Converting Enzyme 2 Binding and Endocytosis.ACS nano · 2020Article
- Robotic DNA Nanostructures.ACS synthetic biology · 2020Review
- Nucleic-Acid Structures as Intracellular Probes for Live Cells.Advanced materials (Deerfield Beach, Fla.) · 2020Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Functionalization of quantum dots (QDs) with a single biomolecular tag using traditional approaches in bulk solution has met with limited success. DNA polyhedra consist of an internal void bounded by a well-defined three-dimensional structured surface. The void can house cargo and the surface can be functionalized with stoichiometric and spatial precision. Here, we show that monofunctionalized QDs can be realized by encapsulating QDs inside DNA icosahedra and functionalizing the DNA shell with an endocytic ligand. We deployed the DNA-encapsulated QDs for real-time imaging of three different endocytic ligands-folic acid, galectin-3 (Gal3) and the Shiga toxin B-subunit (STxB). Single-particle tracking of Gal3- or STxB-functionalized QD-loaded DNA icosahedra allows us to monitor compartmental dynamics along endocytic pathways. These DNA-encapsulated QDs, which bear a unique stoichiometry of endocytic ligands, represent a new class of molecular probes for quantitative imaging of endocytic receptor dynamics.
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Registered trials
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